BioPAX pathway converted from "EGFR interacts with phospholipase C-gamma" in the Reactome database. EGFR interacts with phospholipase C-gamma EGFR interacts with phospholipase C-gamma Activated epidermal growth factor receptors (EGFR) can stimulate phosphatidylinositol (PI) turnover. Activated EGFR can activate phospholipase C-gamma1 (PLC-gamma1) which hydrolyses phosphatidylinositol 4,5-bisphosphate (PIP2) to inositol 1,4,5-triphosphate (IP3) and diacylglycerol (DAG). IP3 is instrumental in the release of calcium from intracellular stores and DAG is involved in protein kinase C activation. Authored: Jassal, B, 2008-02-13 11:13:12 Reviewed: Heldin, CH, 2008-02-12 09:44:02 Phospholipase C-gamma1 binds to the activated EGF receptor Phospholipase C-gamma1 binds to the activated EGF receptor Inactive phospholipase C-gamma1 (PLC-gamma1) binds to activated epidermal growth factor receptor (EGFR). Authored: Jassal, B, 2008-02-13 11:13:12 Reviewed: Heldin, CH, 2008-02-12 09:44:02 Reactome DB_ID: 167682 1 plasma membrane GO 0005886 UniProt:P19174 RecName: Full=1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma-1; EC=3.1.4.11; AltName: Full=Phosphoinositide phospholipase C; AltName: Full=Phospholipase C-gamma-1; Short=PLC-gamma-1; AltName: Full=PLC-II; AltName: Full=PLC-148; GN Name=PLCG1; Synonyms=PLC1; OS Homo sapiens (Human) PLC1 PLCG1 FUNCTION: PLC-gamma is a major substrate for heparin-binding growth factor 1 (acidic fibroblast growth factor)-activated tyrosine kinase. CATALYTIC ACTIVITY: 1-phosphatidyl-1D-myo-inositol 4,5- bisphosphate + H(2)O = 1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol. COFACTOR: Calcium. SUBUNIT: Interacts with CENTG1 via its SH3 domain (By similarity). Interacts with phosphorylated LAT upon TCR activation. Interacts with the Pro-rich domain of TNK1 via its SH3 domain. Associates with BLNK, VAV1, GRB2 and NCK1 in a B-cell antigen receptor- dependent fashion. Interacts with CBLB in activated T-cells; which inhibits phosphorylation. Interacts with SHB. Interacts via its SH3 domain with the Arg/Gly-rich-flanked Pro-rich domains of KHDRBS1/SAM68. This interaction is selectively regulated by arginine methylation of KHDRBS1/SAM68. Interacts with INPP5D/SHIP1 and MIST (By similarity). Interacts with RALGPS1. Interacts (via SH3 domain) with HEV ORF3 protein. INTERACTION: P00519:ABL1; NbExp=1; IntAct=EBI-79387, EBI-375543; P42684:ABL2; NbExp=2; IntAct=EBI-79387, EBI-1102694; Q9H2P0:ADNP; NbExp=1; IntAct=EBI-79387, EBI-1764854; P51816:AFF2; NbExp=1; IntAct=EBI-79387, EBI-1754468; O43918:AIRE; NbExp=1; IntAct=EBI-79387, EBI-1753081; Q9Y2D5:AKAP2; NbExp=1; IntAct=EBI-79387, EBI-1754555; O15085:ARHGEF11; NbExp=1; IntAct=EBI-79387, EBI-311099; P20810:CAST; NbExp=1; IntAct=EBI-79387, EBI-1268770; P20273:CD22; NbExp=1; IntAct=EBI-79387, EBI-78277; Q13111:CHAF1A; NbExp=1; IntAct=EBI-79387, EBI-1020839; Q14008:CKAP5; NbExp=1; IntAct=EBI-79387, EBI-310585; Q8WX92:COBRA1; NbExp=1; IntAct=EBI-79387, EBI-347721; Q7Z408:CSMD2; NbExp=1; IntAct=EBI-79387, EBI-1957312; Q9ULH1:DDEF1; NbExp=2; IntAct=EBI-79387, EBI-346622; O43150:DDEF2; NbExp=2; IntAct=EBI-79387, EBI-310968; O14490:DLGAP1; NbExp=1; IntAct=EBI-79387, EBI-1753207; O95886:DLGAP3; NbExp=1; IntAct=EBI-79387, EBI-1752541; Q92988:DLX4; NbExp=1; IntAct=EBI-79387, EBI-1752755; Q96EV8:DTNBP1; NbExp=1; IntAct=EBI-79387, EBI-465804; Q9H1R2:DUSP15; NbExp=1; IntAct=EBI-79387, EBI-1752795; O43281:EFS; NbExp=1; IntAct=EBI-79387, EBI-718488; P11678:EPX; NbExp=1; IntAct=EBI-79387, EBI-1761505; O43909:EXTL3; NbExp=1; IntAct=EBI-79387, EBI-1754679; O00254:F2RL2; NbExp=1; IntAct=EBI-79387, EBI-1751853; O15360:FANCA; NbExp=1; IntAct=EBI-79387, EBI-81570; P31994:FCGR2B; NbExp=1; IntAct=EBI-79387, EBI-724784; P31995:FCGR2C; NbExp=1; IntAct=EBI-79387, EBI-1396036; P21333:FLNA; NbExp=1; IntAct=EBI-79387, EBI-350432; O75369:FLNB; NbExp=1; IntAct=EBI-79387, EBI-352089; Q14315:FLNC; NbExp=1; IntAct=EBI-79387, EBI-489954; P10912:GHR; NbExp=1; IntAct=EBI-79387, EBI-286316; Q9NZM4:GLTSCR1; NbExp=1; IntAct=EBI-79387, EBI-1754943; P47928:ID4; NbExp=1; IntAct=EBI-79387, EBI-1754719; P26951:IL3RA; NbExp=1; IntAct=EBI-79387, EBI-1757512; Q9H9L3:ISG20L2; NbExp=1; IntAct=EBI-79387, EBI-751335; O60674:JAK2; NbExp=1; IntAct=EBI-79387, EBI-518647; Q07666:KHDRBS1; NbExp=1; IntAct=EBI-79387, EBI-1364; O43561:LAT; NbExp=1; IntAct=EBI-79387, EBI-1222766; P49916:LIG3; NbExp=1; IntAct=EBI-79387, EBI-1753381; P27816:MAP4; NbExp=1; IntAct=EBI-79387, EBI-715255; Q92918:MAP4K1; NbExp=5; IntAct=EBI-79387, EBI-881; Q9NQ76:MEPE; NbExp=1; IntAct=EBI-79387, EBI-1753293; Q13087:PDIA2; NbExp=1; IntAct=EBI-79387, EBI-1752525; O75167:PHACTR2; NbExp=1; IntAct=EBI-79387, EBI-1754409; O75335:PPFIA4; NbExp=1; IntAct=EBI-79387, EBI-947323; P15918:RAG1; NbExp=1; IntAct=EBI-79387, EBI-1755109; P49802:RGS7; NbExp=1; IntAct=EBI-79387, EBI-1754797; Q8TB24:RIN3; NbExp=2; IntAct=EBI-79387, EBI-1570523; P26373:RPL13; NbExp=1; IntAct=EBI-79387, EBI-356849; P10301:RRAS; NbExp=1; IntAct=EBI-79387, EBI-968703; P21817:RYR1; NbExp=1; IntAct=EBI-79387, EBI-1221290; O95487:SEC24B; NbExp=1; IntAct=EBI-79387, EBI-81101; P01008:SERPINC1; NbExp=1; IntAct=EBI-79387, EBI-1039832; Q9UPX8:SHANK2; NbExp=2; IntAct=EBI-79387, EBI-1570571; Q9BYB0:SHANK3; NbExp=1; IntAct=EBI-79387, EBI-1752330; Q9UHI7:SLC23A1; NbExp=1; IntAct=EBI-79387, EBI-1759386; Q15036:SNX17; NbExp=1; IntAct=EBI-79387, EBI-1752620; Q9UNH6:SNX7; NbExp=1; IntAct=EBI-79387, EBI-751422; Q07889:SOS1; NbExp=1; IntAct=EBI-79387, EBI-297487; Q07890:SOS2; NbExp=2; IntAct=EBI-79387, EBI-298181; Q96T58:SPEN; NbExp=1; IntAct=EBI-79387, EBI-765739; Q9H5I1:SUV39H2; NbExp=1; IntAct=EBI-79387, EBI-723127; Q9BXT4:TDRD1; NbExp=1; IntAct=EBI-79387, EBI-1757688; O43493:TGOLN2; NbExp=1; IntAct=EBI-79387, EBI-1752146; Q9BWF2:TRAIP; NbExp=1; IntAct=EBI-79387, EBI-1756205; Q05996:ZP2; NbExp=1; IntAct=EBI-79387, EBI-1755919; DOMAIN: The SH3 domain mediates interaction with MIST (By similarity). The SH3 domain also mediates interaction with RALGPS1. PTM: The receptor-mediated activation of PLC-gamma-1 and PLC- gamma-2 involves their phosphorylation by tyrosine kinases in response to ligation of a variety of growth factor receptors and immune system receptors. PTM: Ubiquitinated by CBLB in activated T-cells (By similarity). SIMILARITY: Contains 1 C2 domain. SIMILARITY: Contains 1 EF-hand domain. SIMILARITY: Contains 2 PH domains. SIMILARITY: Contains 1 PI-PLC X-box domain. SIMILARITY: Contains 1 PI-PLC Y-box domain. SIMILARITY: Contains 2 SH2 domains. SIMILARITY: Contains 1 SH3 domain. Reactome http://www.reactome.org Homo sapiens NCBI_taxonomy 9606 UniProt P19174 Reactome DB_ID: 179882 1 EGF:Phospho-EGFR (Y992, Y1068, Y1086, Y1148, Y1173) dimer [plasma membrane] EGF:Phospho-EGFR (Y992, Y1068, Y1086, Y1148, Y1173) dimer Reactome DB_ID: 179860 2 EGF:Phospho-EGFR [plasma membrane] EGF:Phospho-EGFR Reactome DB_ID: 179803 1 UniProt:P00533-1 RecName: Full=Epidermal growth factor receptor; EC=2.7.10.1; AltName: Full=Receptor tyrosine-protein kinase ErbB-1; Flags: Precursor; GN Name=EGFR; Synonyms=ERBB1; OS Homo sapiens (Human) EGFR ERBB1 FUNCTION: Receptor for EGF, but also for other members of the EGF family, as TGF-alpha, amphiregulin, betacellulin, heparin-binding EGF-like growth factor, GP30 and vaccinia virus growth factor. Is involved in the control of cell growth and differentiation. Phosphorylates MUC1 in breast cancer cells and increases the interaction of MUC1 with C-SRC and CTNNB1/beta-catenin. FUNCTION: Isoform 2/truncated isoform may act as an antagonist. CATALYTIC ACTIVITY: ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate. SUBUNIT: Binds RIPK1. CBL interacts with the autophosphorylated C- terminal tail of the EGF receptor. Part of a complex with ERBB2 and either PIK3C2A or PIK3C2B. The autophosphorylated form interacts with PIK3C2B, maybe indirectly. Interacts with PELP1. Binds MUC1. INTERACTION: Self; NbExp=1; IntAct=EBI-297353, EBI-297353; Q29376:- (xeno); NbExp=1; IntAct=EBI-297353, EBI-1256881; P62157:CALM (xeno); NbExp=1; IntAct=EBI-297353, EBI-397403; P62158:CALM1; NbExp=1; IntAct=EBI-297353, EBI-397435; P62161:Calm1 (xeno); NbExp=2; IntAct=EBI-297353, EBI-397530; P62204:Calm1 (xeno); NbExp=1; IntAct=EBI-297353, EBI-397460; P22681:CBL; NbExp=1; IntAct=EBI-297353, EBI-518228; P22682:Cbl (xeno); NbExp=1; IntAct=EBI-297353, EBI-640919; P13987:CD59; NbExp=1; IntAct=EBI-297353, EBI-297972; P01133:EGF; NbExp=2; IntAct=EBI-297353, EBI-640857; P04626:ERBB2; NbExp=2; IntAct=EBI-297353, EBI-641062; P21860:ERBB3; NbExp=2; IntAct=EBI-297353, EBI-720706; Q15303:ERBB4; NbExp=2; IntAct=EBI-297353, EBI-80371; P62993:GRB2; NbExp=2; IntAct=EBI-297353, EBI-401755; O00750:PIK3C2B; NbExp=4; IntAct=EBI-297353, EBI-641107; Q9UJ41:RABGEF1; NbExp=2; IntAct=EBI-297353, EBI-913954; P98083:Shc1 (xeno); NbExp=1; IntAct=EBI-297353, EBI-300201; P13866:SLC5A1; NbExp=3; IntAct=EBI-297353, EBI-1772443; P63104:YWHAZ; NbExp=1; IntAct=EBI-297353, EBI-347088; SUBCELLULAR LOCATION: Cell membrane; Single-pass type I membrane protein. SUBCELLULAR LOCATION: Isoform 2: Secreted. ALTERNATIVE PRODUCTS: Event=Alternative splicing; Named isoforms=4; Name=1; Synonyms=p170; IsoId=P00533-1; Sequence=Displayed; Name=2; Synonyms=p60, Truncated, TEGFR; IsoId=P00533-2; Sequence=VSP_002887, VSP_002888; Name=3; Synonyms=p110; IsoId=P00533-3; Sequence=VSP_002889, VSP_002890; Name=4; IsoId=P00533-4; Sequence=VSP_002891, VSP_002892; TISSUE SPECIFICITY: Ubiquitously expressed. Isoform 2 is also expressed in ovarian cancers. PTM: Phosphorylation of Ser-695 is partial and occurs only if Thr- 693 is phosphorylated. PTM: Monoubiquitinated and polyubiquitinated upon EGF stimulation; which does not affect tyrosine kinase activity or signaling capacity but may play a role in lysosomal targeting. Polyubiquitin linkage is mainly through 'Lys-63', but linkage through 'Lys-48', 'Lys-11' and 'Lys-29' also occur. DISEASE: Defects in EGFR are associated with lung cancer [MIM:211980]. MISCELLANEOUS: Binding of EGF to the receptor leads to dimerization, internalization of the EGF-receptor complex, induction of the tyrosine kinase activity, stimulation of cell DNA synthesis, and cell proliferation. SIMILARITY: Belongs to the protein kinase superfamily. Tyr protein kinase family. EGF receptor subfamily. SIMILARITY: Contains 1 protein kinase domain. WEB RESOURCE: Name=GeneReviews; URL="http://www.genetests.org/query?gene=EGFR"; WEB RESOURCE: Name=Wikipedia; Note=EGFR entry; URL="http://en.wikipedia.org/wiki/Epidermal_growth_factor_receptor"; UniProt P00533 phosphate group on L-Tyrosine [ChEBI:6313] 1068 of UniProt:P00533-1 Epidermal growth factor receptor precursor (EC 2.7.1.112) (Receptor protein-tyrosine kinase ErbB-1) residue: L-Tyrosine [ChEBI:17895] 1068 EQUAL phosphate group ChEBI 35780 phosphate group on L-Tyrosine [ChEBI:6313] 1148 of UniProt:P00533-1 Epidermal growth factor receptor precursor (EC 2.7.1.112) (Receptor protein-tyrosine kinase ErbB-1) residue: L-Tyrosine [ChEBI:17895] 1148 EQUAL phosphate group on L-Tyrosine [ChEBI:6313] 1173 of UniProt:P00533-1 Epidermal growth factor receptor precursor (EC 2.7.1.112) (Receptor protein-tyrosine kinase ErbB-1) residue: L-Tyrosine [ChEBI:17895] 1173 EQUAL phosphate group on L-Tyrosine [ChEBI:6313] 1086 of UniProt:P00533-1 Epidermal growth factor receptor precursor (EC 2.7.1.112) (Receptor protein-tyrosine kinase ErbB-1) residue: L-Tyrosine [ChEBI:17895] 1086 EQUAL phosphate group on L-Tyrosine [ChEBI:6313] 992 of UniProt:P00533-1 Epidermal growth factor receptor precursor (EC 2.7.1.112) (Receptor protein-tyrosine kinase ErbB-1) residue: L-Tyrosine [ChEBI:17895] 992 EQUAL Chain Coordinates 25 EQUAL 1210 EQUAL Reactome DB_ID: 179863 1 extracellular region GO 0005576 UniProt:P01133 RecName: Full=Pro-epidermal growth factor; Short=EGF; Contains: RecName: Full=Epidermal growth factor; AltName: Full=Urogastrone; Flags: Precursor; GN Name=EGF; OS Homo sapiens (Human) EGF FUNCTION: EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6. INTERACTION: P00533:EGFR; NbExp=2; IntAct=EBI-640857, EBI-297353; SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein. TISSUE SPECIFICITY: Expressed in kidney, salivary gland, cerebrum and prostate. DISEASE: Defects in EGF are the cause of hypomagnesemia type 4 (HOMG4) [MIM:611718]; also known as renal hypomagnesemia normocalciuric. HOMG4 is a disorder characterized by massive renal hypomagnesemia and normal levels of serum calcium and calcium excretion. Clinical features include seizures, mild-to mederate psychomotor retardation, and brisk tendon reflexes. SIMILARITY: Contains 9 EGF-like domains. SIMILARITY: Contains 9 LDL-receptor class B repeats. WEB RESOURCE: Name=Wikipedia; Note=Epidermal growth factor entry; URL="http://en.wikipedia.org/wiki/Epidermal_growth_factor"; UniProt P01133 971 EQUAL 1023 EQUAL Reactome 179860 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=179860 Reactome REACT_9712 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_9712.1 Reactome 179882 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=179882 Reactome REACT_9673 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_9673.1 Reactome DB_ID: 212717 1 Activated EGFR:PLC-gamma1 [plasma membrane] Activated EGFR:PLC-gamma1 Reactome DB_ID: 179882 1 Reactome DB_ID: 202320 1 cytosol GO 0005829 PH domain PH domain 27 142 SH2 domain SH2 domain 550 657 SH2 domain SH2 domain 688 756 SH3 domain SH3 domain 791 851 1 EQUAL 1290 EQUAL Reactome 212717 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=212717 Reactome REACT_13280 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_13280.1 Reactome 212706 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=212706 Reactome REACT_12401 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_12401.1 2153914 Pubmed 1990 Tyrosine kinase activity is essential for the association of phospholipase C-gamma with the epidermal growth factor receptor Margolis, B Bellot, F Honegger, AM Ullrich, A Schlessinger, J Zilberstein, A Mol Cell Biol 10:435-41 2472219 Pubmed 1989 Phospholipase C-gamma is a substrate for the PDGF and EGF receptor protein-tyrosine kinases in vivo and in vitro Meisenhelder, J Suh, PG Rhee, SG Hunter, T Cell 57:1109-22 2.7.10 EGFR activates PLC-gamma1 by phosphorylation EGFR activates PLC-gamma1 by phosphorylation EGFR phosphorylates PLC-gamma1, thus activating it. Authored: Jassal, B, 2008-02-13 11:13:12 Reviewed: Heldin, CH, 2008-02-12 09:44:02 Reactome DB_ID: 212717 1 Reactome DB_ID: 113592 4 ATP [ChEBI:15422] ATP Adenosine 5'-triphosphate ChEBI 15422 Reactome DB_ID: 212703 1 Activated EGFR:Phospho-PLC-gamma1 [plasma membrane] Activated EGFR:Phospho-PLC-gamma1 Reactome DB_ID: 167679 1 phosphate group on L-Tyrosine [ChEBI:17895] 771 of UniProt:P19174 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 1 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (PLC-gamma-1) (Phospholipase C-gamma-1) (PLC-II) (PLC-148) residue: L-Tyrosine [ChEBI:17895] 771 EQUAL phosphate group on L-Tyrosine [ChEBI:17895] 783 of UniProt:P19174 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 1 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (PLC-gamma-1) (Phospholipase C-gamma-1) (PLC-II) (PLC-148) residue: L-Tyrosine [ChEBI:17895] 783 EQUAL phosphate group on L-Tyrosine [ChEBI:17895] 1254 of UniProt:P19174 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 1 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (PLC-gamma-1) (Phospholipase C-gamma-1) (PLC-II) (PLC-148) residue: L-Tyrosine [ChEBI:17895] 1254 EQUAL phosphate group on L-Tyrosine [ChEBI:17895] 472 of UniProt:P19174 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 1 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (PLC-gamma-1) (Phospholipase C-gamma-1) (PLC-II) (PLC-148) residue: L-Tyrosine [ChEBI:17895] 472 EQUAL 1 EQUAL 1290 EQUAL Reactome DB_ID: 179882 1 Reactome 212703 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=212703 Reactome REACT_13347 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_13347.1 Reactome DB_ID: 29370 4 ADP [ChEBI:16761] ADP Adenosine 5'-diphosphate ChEBI 16761 PHYSIOL-LEFT-TO-RIGHT ACTIVATION Reactome DB_ID: 212717 GO 0004713 GO molecular function Reactome 212705 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=212705 Reactome 212710 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=212710 Reactome REACT_12569 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_12569.1 1689311 Pubmed 1990 Identification of two epidermal growth factor-sensitive tyrosine phosphorylation sites of phospholipase C-gamma in intact HSC-1 cells Wahl, MI Nishibe, S Kim, JW Kim, H Rhee, SG Carpenter, G J Biol Chem 265:3944-8 Active PLC-gamma1 dissociates from EGFR Active PLC-gamma1 dissociates from EGFR Once activated PLC-gamma1 dissociates from EGFR, it can hydrolyze PIP2. Authored: Jassal, B, 2008-02-13 11:13:12 Reviewed: Heldin, CH, 2008-02-12 09:44:02 Reactome DB_ID: 212703 1 Reactome DB_ID: 167679 1 phosphate group on L-Tyrosine [ChEBI:17895] 771 of UniProt:P19174 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 1 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (PLC-gamma-1) (Phospholipase C-gamma-1) (PLC-II) (PLC-148) residue: L-Tyrosine [ChEBI:17895] 771 EQUAL phosphate group on L-Tyrosine [ChEBI:17895] 783 of UniProt:P19174 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 1 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (PLC-gamma-1) (Phospholipase C-gamma-1) (PLC-II) (PLC-148) residue: L-Tyrosine [ChEBI:17895] 783 EQUAL phosphate group on L-Tyrosine [ChEBI:17895] 1254 of UniProt:P19174 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 1 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (PLC-gamma-1) (Phospholipase C-gamma-1) (PLC-II) (PLC-148) residue: L-Tyrosine [ChEBI:17895] 1254 EQUAL phosphate group on L-Tyrosine [ChEBI:17895] 472 of UniProt:P19174 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 1 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (PLC-gamma-1) (Phospholipase C-gamma-1) (PLC-II) (PLC-148) residue: L-Tyrosine [ChEBI:17895] 472 EQUAL 1 EQUAL 1290 EQUAL Reactome DB_ID: 179882 1 Reactome 212713 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=212713 Reactome REACT_12407 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_12407.1 Reactome 212718 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=212718 Reactome REACT_12478 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_12478.1 1501243 Pubmed 1992 Epidermal growth factor receptor: elements of intracellular communication Hernández-Sotomayor, SM Carpenter, G J Membr Biol 128:81-9 GO 0007165 GO biological process