VCell 4.6 (click to run-current public beta 9-11-08)

• Implementation of Global Parameters for BioModels.
• Resources: Links to BioModels database
• Protein Subcellular Location Image Database (PSLID) import and data handling in FieldData
• Allow membrane field data from simulation results
• Improved spatial data analysis for ROIs.
  • Predefined ROIs for existing spatial compartments.
  • ROIs  from user defined Boolean functions
  • ROIs from user drawn polygons
• CVODE solver used for Optimization in parameter estimation.
• Support for both Intel and G5 macs.
• Basic CellML import into MathModels.
• Added sort and search functions to Math Viewer and Math Model editor.
• Feature and Membrane sizes available for use in expressions in non-spatial models.

• Hybrid Stochastic simulations (HySSS)
• Differential Algebraic Solver for non-spatial "fast" systems
• math generation improvements (improved comparison)
• additional SBML improvements (e.g. libSBML 3.0.2)
• formalize VCML as XML document

VCell 4.4 (4-1-08)

• nonspatial stochastic modeling
• field data (using images data as input to simulations)
• annotations (MIRIAM compliant)
• better SBML support

VCell 4.3.1 (9/19/2007)

• BioNetGen@VCell
• Copy/Paste parameters (initial conditions, math overrides, simulation results and parameter estimation values) amongst each other
• Publish documents
• Improvements in memory efficiency and resource utilization
• Improvements in SBML import/export

VCell 4.2 (9/1/2006)

• Parameter scans
• Faster surface visualization
• Automated GUI testing framework
• 2D/3D Membrane Diffusion added to BioModels and MathModels.
  
• 3D Surface Visualization for spatial simulation results.
  
• Reaction diagram draws faster for large networks, and easier to resize
  
• Known molecular weights added to controlled vocabulary, and improved queries Species (from models or controlled vocabulary)
  
• Model Editor layout improved.
  
• additional simulation status is provided while running jobs
  
• Stiff solver support for uniform output time step (useful for SBML support)
  
• Added 2D/3D membrane diffusion and sensitivity analysis to numerical methods testing framework.
  

VCell 4.1 (4/3/2006)

• 2D/3D Membrane Diffusion added to BioModels and MathModels.
  
• 3D Surface Visualization for spatial simulation results.
  
• Reaction diagram draws faster for large networks, and easier to resize
  
• Known molecular weights added to controlled vocabulary, and improved queries Species (from models or controlled vocabulary)
  
• Model Editor layout improved.
  
• Additional simulation status is provided while running jobs
  
• Stiff solver support for uniform output time step (useful for SBML support)
  
• Added 2D/3D membrane diffusion and sensitivity analysis to numerical methods testing framework.
  

• Completely redesigned user interface.
• Multiple document interface (MDI).
• Multiple application viewing inside each BioModel.
• Database Manager for managing documents.