Name: “hillelab: JungSR_PAR2_desensitization2015”
Saved: Mon, 13 Jun 2016  23:24:34 GMT
vcell identifier: biomodel-100961371
Owned by: “jsr007”

download model (.vcml)

Compartments, Species, Reactions
  • Compartment "EX".   (type: Volume)
    • Species "AP_EX"
    • Species "K_EX"
    • Species "IP3_pipette"
    • Species "AP_conc_EX"
    • Reaction "Oxo_appl"   (AP_conc_EX → AP_EX)
  • Compartment "C".   (type: Volume)
    • Species "dynamin"
    • Species "C1_dom_C"
    • Species "IP3_C"
    • Species "Ca_Fura4F_C"
    • Species "K_C"
    • Species "Fura4F_C"
    • Species "Arrestin2"
    • Species "IP3_LibraVIII_C"
    • Species "IP3_PH_YFP_C"
    • Species "LibraVIII_C"
    • Species "Palk_C1"
    • Species "PH_YFP_C"
    • Species "PKC_cyto"
    • Species "Palk_C2"
    • Species "Ca_C"
    • Species "Palk_O4"
    • Species "Palk_C3"
    • Species "Arrestin1"
    • Reaction "PH_YFP_IP3"   (IP3_C + PH_YFP_C → IP3_PH_YFP_C)
    • Reaction "r12"   (Palk_C1 → Palk_C2)
    • Reaction "r24"   (Palk_C2 → Palk_O4)
    • Reaction "IP3deg_Palk"   (IP3_C → ∅)
    • Reaction "IP3_LibraVIII"   (LibraVIII_C + IP3_C → IP3_LibraVIII_C)
    • Reaction "IP3Pase_FDH"   (IP3_C → ∅)
    • Reaction "r23"   (Palk_C2 → Palk_C3)
    • Reaction "Cabind_Fura4F"   (Fura4F_C + Ca_C → Ca_Fura4F_C)
  • Compartment "Ca_store".   (type: Volume)
    • Species "Ca_Ca_store"
  • Compartment "M".   (type: Membrane)
    • Species "RLPAC_M"
    • Species "endocytosis"
    • Species "PI_M"
    • Species "KCNQ_M"
    • Species "G_GDP_M"
    • Species "PH_YFP_PIP2_M"
    • Species "RLPA2_M"
    • Species "PA_2AG_M"
    • Species "RLGbeta_M"
    • Species "KCNQ_PIP2_M"
    • Species "PLC_M"
    • Species "GaGTP_M"
    • Species "GaGDP_PLC_M"
    • Species "RLP_M"
    • Species "Gbeta_M"
    • Species "RGbeta_M"
    • Species "R_M"
    • Species "Ga_GDP_M"
    • Species "RG_GDP_M"
    • Species "PIP2_M"
    • Species "boundPIP2_M"
    • Species "DAG_M"
    • Species "RL_M"
    • Species "GaGTP_PLC_M"
    • Species "RLG_GDP_M"
    • Species "PKC_DAG_M"
    • Species "RP_M"
    • Species "C1_DAG_M"
    • Species "PI4P_M"
    • Species "RLPA1"
    • Reaction "PIP5K_5Pase"   (PI4P_M → PIP2_M)
    • Reaction "PH_YFP_PIP2"   (PH_YFP_C + PIP2_M → PH_YFP_PIP2_M)
    • Reaction "NE_RLG"   (RLG_GDP_M → RLGbeta_M + GaGTP_M)
    • Reaction "reaction 1 for phosphorylation of ligand bound receptor"   (RL_M → RLP_M)
    • Reaction "reconstitution"   (Gbeta_M + Ga_GDP_M → G_GDP_M)
    • Reaction "G2"   (RL_M + G_GDP_M → RLG_GDP_M)
    • Reaction "DAGPase"   (DAG_M → PA_2AG_M)
    • Reaction "GTPase_Ga"   (GaGTP_M → Ga_GDP_M)
    • Reaction "PLCassoc"   (PLC_M + GaGTP_M → GaGTP_PLC_M)
    • Reaction "L2"   (RG_GDP_M + AP_EX → RLG_GDP_M)
    • Reaction "clathrin formation rate"   (dynamin + RLPA2_M → RLPAC_M)
    • Reaction "L1"   (R_M + AP_EX → RL_M)
    • Reaction "PLC_on_PI4P"   (PI4P_M → DAG_M)
    • Reaction "reaction 2 for phosphorylation of receptor"   (R_M → RP_M)
    • Reaction "NE_G"   (G_GDP_M → GaGTP_M + Gbeta_M)
    • Reaction "ligand2"   (RP_M + AP_EX → RLP_M)
    • Reaction "PI4K_4Pase"   (PI_M → PI4P_M)
    • Reaction "IP3_dialysis"   (IP3_pipette → IP3_C)
    • Reaction "VSP"   (PIP2_M → PI4P_M)
    • Reaction "G1beta"   (Gbeta_M + R_M → RGbeta_M)
    • Reaction "NE_GaP"   (GaGDP_PLC_M → GaGTP_PLC_M)
    • Reaction "arrestin binding"   (RLP_M + Arrestin2 → RLPA2_M)
    • Reaction "PIP2bindKCNQ"   (KCNQ_M + PIP2_M → KCNQ_PIP2_M)
    • Reaction "pinching"   (RLPAC_M + dynamin → endocytosis)
    • Reaction "G2beta"   (Gbeta_M + RL_M → RLGbeta_M)
    • Reaction "PIP2hydr"   (PIP2_M → IP3_C + DAG_M)
    • Reaction "PLCdiss"   (GaGDP_PLC_M → Ga_GDP_M + PLC_M)
    • Reaction "G1"   (R_M + G_GDP_M → RG_GDP_M)
    • Reaction "GTPase_GaP"   (GaGTP_PLC_M → GaGDP_PLC_M)
    • Reaction "PKC_DAG binding"   (DAG_M + PKC_cyto → PKC_DAG_M)
    • Reaction "C1bindDAG"   (C1_dom_C + DAG_M → C1_DAG_M)
    • Reaction "PIP2_buffering"   (PIP2_M → boundPIP2_M)
    • Reaction "NE_RG"   (RG_GDP_M → GaGTP_M + RGbeta_M)
    • Reaction "L2beta"   (RGbeta_M + AP_EX → RLGbeta_M)
    • Reaction "Arrestin 1"   (RLP_M + Arrestin1 → RLPA1)
    • Reaction "RLPA1 to clathrin"   (RLPA1 → RLPAC_M)
    • Reaction "KCNQ2/3"   (K_EX → K_C)
  • Compartment "ERM".   (type: Membrane)
    • Species "noninactiveIP3R"
    • Species "inactiveIP3R"
    • Reaction "h_reaction_IP3Rinactivation"   (noninactiveIP3R → inactiveIP3R)
    • Reaction "SERCA_flux_FDH"   (Ca_C → Ca_Ca_store)
    • Reaction "SERCA_Palk"   (Ca_C → Ca_Ca_store)
    • Reaction "leak_Palk"   (Ca_C → Ca_Ca_store)
    • Reaction "IP3R_flux_FDH"   (Ca_C → Ca_Ca_store)
    • Reaction "RyR_Palk"   (Ca_C → Ca_Ca_store)
    • Reaction "IP3R_Palk"   (Ca_C → Ca_Ca_store)
    • Reaction "ER_leak_flux_FDH"   (Ca_C → Ca_Ca_store)