Name: “Spine Model Final Rangamani et al PNAS 2016 “
Saved: Wed, 24 Aug 2016  20:16:07 GMT
vcell identifier: biomodel-102061382
Owned by: “prangamani”

download model (.vcml)

Compartments, Species, Reactions
  • Compartment "c0".   (type: Volume)
  • Compartment "Cytoplasm".   (type: Volume)
    • Species "F_actin"
    • Species "CaMKII_F_actin"
    • Species "Il1_act"
    • Species "Myoppase"
    • Species "Myoppase_act"
    • Species "ROCK"
    • Species "Il1"
    • Species "RhoGTP"
    • Species "ROCK_act"
    • Species "LIMK"
    • Species "LIMK_P"
    • Species "RhoGAP_act"
    • Species "RhoGDP"
    • Species "RhoGEF"
    • Species "RhoGEF_act"
    • Species "RhoGAP"
    • Species "Ng"
    • Species "CaM_Ng"
    • Species "SSH1_act"
    • Species "cdc42GTP"
    • Species "WASP"
    • Species "PP1"
    • Species "PP1_act"
    • Species "MLC"
    • Species "MLC_p"
    • Species "arp23"
    • Species "WASP_act"
    • Species "B"
    • Species "R"
    • Species "cdc42GDP"
    • Species "Ca_CaM"
    • Species "Bp"
    • Species "CaM"
    • Species "arp23_act"
    • Species "SSH1"
    • Species "Ca"
    • Species "CaMKII"
    • Species "CaMKIIp"
    • Species "G_actin"
    • Species "CaMKII_G_actin"
    • Species "Calcineurin_act"
    • Species "Cdc42GEF"
    • Species "cdc42GEF_act"
    • Species "Cofilin_p"
    • Species "Calcineurin"
    • Species "cofilin_act"
    • Reaction "Myoppase inactivation by ROCK"   (Myoppase_act → Myoppase)
    • Reaction "Cofilin inactivation by LIMK"   (cofilin_act → Cofilin_p)
    • Reaction "PP1 inactivation by CaMKII"   (PP1_act → PP1)
    • Reaction "calcium binding calmodulin"   (3 Ca + CaM → Ca_CaM)
    • Reaction "calcinuerin inactivation"   (Calcineurin_act → Calcineurin)
    • Reaction "Cofilin activation through SSH1 dephosphorylation"   (Cofilin_p → cofilin_act)
    • Reaction "RhoGTP hydrolysis"   (RhoGTP → RhoGDP)
    • Reaction "SSH1 dephosphorylation by CaN"   (SSH1 → SSH1_act)
    • Reaction "cdc42 activates WASP"   (cdc42GTP + WASP → WASP_act)
    • Reaction "cdc42 hydrolysis"   (cdc42GTP → cdc42GDP)
    • Reaction "LIMK activation by ROCK"   (LIMK → LIMK_P)
    • Reaction "MLC Phosphorylation by ROCK"   (MLC → MLC_p)
    • Reaction "Cdc42 GEF inactivation"   (cdc42GEF_act → Cdc42GEF)
    • Reaction "Arp23 inactivation"   (arp23_act → arp23)
    • Reaction "Barbed ends"   (∅ → B)
    • Reaction "RhoGEF activation by CaMKII"   (RhoGEF → RhoGEF_act)
    • Reaction "Il1 inactivation"   (Il1_act → Il1)
    • Reaction "Il1 activation by CaN"   (Il1 → Il1_act)
    • Reaction "Arp23 activation"   (arp23 + WASP_act → arp23_act)
    • Reaction "severing"   (F_actin → G_actin)
    • Reaction "CaMKII activation by CaM"   (CaMKII → CaMKIIp)
    • Reaction "PP1 activation by IL1"   (PP1 → PP1_act)
    • Reaction "cdc42 activation"   (cdc42GDP → cdc42GTP)
    • Reaction "pushing barbed ends"   (∅ → Bp)
    • Reaction "CaMKII sequestration of G-actin"   (CaMKII + G_actin → CaMKII_G_actin)
    • Reaction "Calmodulin binding neurogranin"   (Ng + CaM → CaM_Ng)
    • Reaction "Radius"   (∅ → R)
    • Reaction "RhoGAP inactivation by PP1"   (RhoGAP_act → RhoGAP)
    • Reaction "RhoGTP activation by RhoGEF"   (RhoGDP → RhoGTP)
    • Reaction "Myoppase activation by autodephosphorylation"   (Myoppase → Myoppase_act)
    • Reaction "Rho GEF inactivation"   (RhoGEF_act → RhoGEF)
    • Reaction "Calcineurin activation by CaM"   (Calcineurin → Calcineurin_act)
    • Reaction "LIMK inactivation by ROCK"   (LIMK_P → LIMK)
    • Reaction "MLC dephosphorylation"   (MLC_p → MLC)
    • Reaction "CaMKII inactivation"   (CaMKIIp → CaMKII)
    • Reaction "ROCK activation by Rho"   (ROCK + RhoGTP → ROCK_act)
    • Reaction "cdc42 GEF activation"   (Cdc42GEF → cdc42GEF_act)
    • Reaction "myosin phosphatase activation basal"   (Myoppase → Myoppase_act)
    • Reaction "MLC phosphorylation basal"   (MLC → MLC_p)
    • Reaction "ROCK inactivation 1"   (ROCK_act → ∅)
    • Reaction "RhoGAP activation by CaMKII"   (RhoGAP → RhoGAP_act)
    • Reaction "CaMKII sequestration of F-actin"   (CaMKII + F_actin → CaMKII_F_actin)
    • Reaction "SSH1 phosphorylation by CaMKIIp"   (SSH1_act → SSH1)
    • Reaction "Actin growth "   (F_actin + arp23_act + G_actin → F_actin)
  • Compartment "plasma membrane".   (type: Membrane)