Name: “Mohan chemotaxis 2017”
Saved: Mon, 12 Jun 2017  23:05:00 GMT
vcell identifier: biomodel-113655498
Owned by: “jnosbis”

download model (.vcml)

Compartments, Species, Reactions
  • Compartment "Extracellular".   (type: Volume)
    • Species "PDGF_gradient_extracellular"
    • Species "PDGF_uniform_extracellular"
  • Compartment "Nucleus".   (type: Volume)
  • Compartment "Cytosol".   (type: Volume)
    • Species "E_inactive_PLC"
    • Species "C_PKC_inactive"
    • Species "M_cytosolic_MARCKS"
    • Species "Mp"
    • Reaction "MARCKS dephosphorylation"   (Mp → M_cytosolic_MARCKS)
  • Compartment "plasma_membrane".   (type: Membrane)
    • Species "R_factor_plasmaMembrane"
    • Species "RplasmaMembrane"
    • Species "C1_plasmaMembrane"
    • Species "C2_plasmaMembrane"
    • Species "e_active_PLC"
    • Species "pT_PIP2"
    • Species "d_DAG"
    • Species "c_DAG_PKC"
    • Species "cStar"
    • Species "m"
    • Reaction "Rsynthesis"   (∅ → RplasmaMembrane)
    • Reaction "R_Turnover"   (RplasmaMembrane → ∅)
    • Reaction "PDGF_binding"   (RplasmaMembrane → C1_plasmaMembrane)
    • Reaction "C1_turnover"   (C1_plasmaMembrane → ∅)
    • Reaction "C1_dimerization"   (2 C1_plasmaMembrane → C2_plasmaMembrane)
    • Reaction "C2_uncoupling"   (C2_plasmaMembrane → C1_plasmaMembrane + RplasmaMembrane)
    • Reaction "C2_Internalization"   (C2_plasmaMembrane → ∅)
    • Reaction "PLC_receptor_binding V_PLC"   (E_inactive_PLC → e_active_PLC)
    • Reaction "PIP2_Synthesis"   (∅ → pT_PIP2)
    • Reaction "PLC catalyzed PIP2 hydrolysis"   (pT_PIP2 → d_DAG)
    • Reaction "PIP2_hydrolysis"   (pT_PIP2 → ∅)
    • Reaction "DAG_consumption"   (d_DAG → ∅)
    • Reaction "MARCKS phosphorylation by PKC"   (m → Mp)
    • Reaction "V_MARCKS"   (M_cytosolic_MARCKS → m)
    • Reaction "V_PKC"   (d_DAG + C_PKC_inactive → cStar)
    • Reaction "V_dpc"   (cStar → c_DAG_PKC)
    • Reaction "Vpc1"   (c_DAG_PKC → cStar)
    • Reaction "V_pc2"   (c_DAG_PKC → cStar)
    • Reaction "V_offc"   (c_DAG_PKC → C_PKC_inactive + d_DAG)
  • Compartment "Nuclear_Membrane".   (type: Membrane)