Name: “Calebiro_PLoS-Biol_2009”
Saved: Tue, 18 Aug 2009  12:56:49 GMT
vcell identifier: biomodel-34855932
Owned by: “davide.calebiro”

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Compartments, Species, Reactions
  • Compartment "IC_compartment".   (type: Volume)
  • Compartment "extra".   (type: Volume)
    • Species "ligand_extra"
    • Species "removed_ligand_extra"
    • Species "perfusion_speed_extra"
    • Reaction "reaction0"   (ligand_extra → removed_ligand_extra)
  • Compartment "cyto".   (type: Volume)
    • Species "ligand_cyto"
    • Species "ATP_cyto"
    • Species "G_a_s_ICSC_cyto"
    • Species "bg_cyto"
    • Species "R2C2_cyto"
    • Species "c3_R2C2_cyto"
    • Species "internalized_GPCR_cyto"
    • Species "cAMP_cyto"
    • Species "PKA_active_cyto"
    • Species "G_protein_cyto"
    • Species "G_a_s_cyto"
    • Species "AMP_cyto"
    • Species "GRK_cyto"
    • Species "c_R2C2_cyto"
    • Species "c2_R2C2_cyto"
    • Species "GRK_bg_cyto"
    • Species "G_GDP_cyto"
    • Species "PDE4_cyto"
    • Species "G_GDP_ICSC_cyto"
    • Species "GRK_bg_ICSC_cyto"
    • Species "G_protein_ICSC_cyto"
    • Species "bg_ICSC_cyto"
    • Species "GRK_ICSC_cyto"
    • Species "recycling_GPCR_cyto"
    • Reaction "trimer_ICSC"   (bg_ICSC_cyto + G_GDP_ICSC_cyto → G_protein_ICSC_cyto)
    • Reaction "GTPase"   (G_a_s_cyto → G_GDP_cyto)
    • Reaction "bg_binds_GRK1"   (bg_ICSC_cyto + GRK_ICSC_cyto → GRK_bg_ICSC_cyto)
    • Reaction "B2"   (cAMP_cyto + c_R2C2_cyto → c2_R2C2_cyto)
    • Reaction "A1"   (cAMP_cyto + c2_R2C2_cyto → c3_R2C2_cyto)
    • Reaction "trimer"   (bg_cyto + G_GDP_cyto → G_protein_cyto)
    • Reaction "A2"   (c3_R2C2_cyto + cAMP_cyto → PKA_active_cyto)
    • Reaction "GTPase_G_a_s-ICSC"   (G_a_s_ICSC_cyto → G_GDP_ICSC_cyto)
    • Reaction "pde4"   (cAMP_cyto → AMP_cyto)
    • Reaction "bg_binds_GRK"   (GRK_cyto + bg_cyto → GRK_bg_cyto)
    • Reaction "B1"   (R2C2_cyto + cAMP_cyto → c_R2C2_cyto)
  • Compartment "cyto_mem".   (type: Membrane)
    • Species "GPCR_cyto_mem"
    • Species "G_GPCR_cyto_mem"
    • Species "ligand_GPCR_cyto_mem"
    • Species "ligand_internalizer_cyto_mem"
    • Species "ligand_G_GPCR_cyto_mem"
    • Species "AC_cyto_mem"
    • Species "ligand_GPCR_p_cyto_mem"
    • Species "AC_active_cyto_mem"
    • Reaction "G_binds_GPCR"   (GPCR_cyto_mem + G_protein_cyto → G_GPCR_cyto_mem)
    • Reaction "GPCR_recycling"   (recycling_GPCR_cyto → GPCR_cyto_mem)
    • Reaction "GRK"   (ligand_GPCR_cyto_mem → ligand_GPCR_p_cyto_mem)
    • Reaction "GPCR_fast_recycling"   (internalized_GPCR_cyto → GPCR_cyto_mem)
    • Reaction "GPCR_internalization"   (ligand_G_GPCR_cyto_mem → internalized_GPCR_cyto + G_protein_cyto)
    • Reaction "AC_active"   (ATP_cyto → cAMP_cyto)
    • Reaction "ligand_binds_GPCR"   (GPCR_cyto_mem + ligand_extra → ligand_GPCR_cyto_mem)
    • Reaction "AC_basal"   (ATP_cyto → cAMP_cyto)
    • Reaction "AC_activation"   (G_a_s_cyto + AC_cyto_mem → AC_active_cyto_mem)
    • Reaction "ligand_binds_G_GPCR"   (ligand_extra + G_GPCR_cyto_mem → ligand_G_GPCR_cyto_mem)
    • Reaction "activate_Gs"   (ligand_G_GPCR_cyto_mem → bg_cyto + G_a_s_cyto + ligand_GPCR_cyto_mem)
    • Reaction "G_binds_ligand_GPCR"   (ligand_GPCR_cyto_mem + G_protein_cyto → ligand_G_GPCR_cyto_mem)
    • Reaction "GRK_bg"   (ligand_GPCR_cyto_mem → ligand_GPCR_p_cyto_mem)
    • Reaction "ligand_internalization"   (ligand_extra → ligand_cyto)
  • Compartment "IC_compartment_mem".   (type: Membrane)
    • Species "ligand_GPCR_IC_compartment_mem"
    • Species "GPCR_IC_compartment_mem"
    • Species "AC_IC_compartment_mem"
    • Species "ligand_GPCR_p_IC_compartment_mem"
    • Species "G_GPCR_IC_compartment_mem"
    • Species "AC_active_IC_compartment_mem"
    • Species "ligand_G_GPCR_IC_compartment_mem"
    • Reaction "activate_Gs1"   (ligand_G_GPCR_IC_compartment_mem → G_a_s_ICSC_cyto + ligand_GPCR_IC_compartment_mem + bg_ICSC_cyto)
    • Reaction "AC_basal1"   (ATP_cyto → cAMP_cyto)
    • Reaction "GPCR_ICSC_to_recycing-comp"   (ligand_G_GPCR_IC_compartment_mem → recycling_GPCR_cyto + G_protein_ICSC_cyto)
    • Reaction "AC_activation1"   (G_a_s_ICSC_cyto + AC_IC_compartment_mem → AC_active_IC_compartment_mem)
    • Reaction "GRK_bg1"   (ligand_GPCR_IC_compartment_mem → ligand_GPCR_p_IC_compartment_mem)
    • Reaction "ligand_binds_G_GPCR1"   (ligand_cyto + G_GPCR_IC_compartment_mem → ligand_G_GPCR_IC_compartment_mem)
    • Reaction "GPCR_to_ICSC"   (internalized_GPCR_cyto → GPCR_IC_compartment_mem)
    • Reaction "AC_active1"   (ATP_cyto → cAMP_cyto)
    • Reaction "G_binds_ligand_GPCR1"   (ligand_GPCR_IC_compartment_mem + G_protein_ICSC_cyto → ligand_G_GPCR_IC_compartment_mem)
    • Reaction "G_binds_GPCR1"   (GPCR_IC_compartment_mem + G_protein_ICSC_cyto → G_GPCR_IC_compartment_mem)
    • Reaction "GRK1"   (ligand_GPCR_IC_compartment_mem → ligand_GPCR_p_IC_compartment_mem)
    • Reaction "ligand_binds_GPCR1"   (GPCR_IC_compartment_mem + ligand_cyto → ligand_GPCR_IC_compartment_mem)
2018-07-12T19:23:17+00:00 February 16th, 2018|biomodel|