Name: “PDGF gradient sensing”
Saved: Tue, 20 Oct 2009  14:52:40 GMT
vcell identifier: biomodel-36275161
Owned by: “jmhaugh”

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Compartments, Species, Reactions
  • Compartment "cytosol".   (type: Volume)
    • Species "PI3K_cytosol"
    • Species "GFP_AktPH_cytosol"
  • Compartment "nucleus".   (type: Volume)
    • Species "GFP_AktPH_nucleus"
    • Species "PI3K_nucleus"
  • Compartment "extracellular".   (type: Volume)
    • Species "PDGF_gradient_extracellular"
    • Species "PDGF_uniform_extracellular"
  • Compartment "plasma_membrane".   (type: Membrane)
    • Species "C2_PI3K_plasma_membrane"
    • Species "C2_PI3K2_plasma_membrane"
    • Species "PIP3_plasma_membrane"
    • Species "PIP3_AktPH_plasma_membrane"
    • Species "enzyme_factor_plasma_membrane"
    • Species "R_factor_plasma_membrane"
    • Species "C1_plasma_membrane"
    • Species "C2_plasma_membrane"
    • Species "R_plasma_membrane"
    • Reaction "basal PIP3 synthesis"   (∅ → PIP3_plasma_membrane)
    • Reaction "C1 dimerization"   (2 C1_plasma_membrane → C2_plasma_membrane)
    • Reaction "R turnover"   (R_plasma_membrane → ∅)
    • Reaction "C1 turnover"   (C1_plasma_membrane → ∅)
    • Reaction "C2_PI3K2 uncoupling"   (C2_PI3K2_plasma_membrane → R_plasma_membrane + C1_plasma_membrane + 2 PI3K_cytosol)
    • Reaction "C2_PI3K uncoupling"   (C2_PI3K_plasma_membrane → R_plasma_membrane + C1_plasma_membrane + PI3K_cytosol)
    • Reaction "PIP3 degradation"   (PIP3_plasma_membrane → ∅)
    • Reaction "GFP_AktPH binding"   (GFP_AktPH_cytosol + PIP3_plasma_membrane → PIP3_AktPH_plasma_membrane)
    • Reaction "C2_PI3K2 internalization"   (C2_PI3K2_plasma_membrane → 2 PI3K_cytosol)
    • Reaction "R synthesis"   (∅ → R_plasma_membrane)
    • Reaction "PDGF binding"   (R_plasma_membrane → C1_plasma_membrane)
    • Reaction "PI3K2 binding"   (C2_PI3K_plasma_membrane + PI3K_cytosol → C2_PI3K2_plasma_membrane)
    • Reaction "C2 internalization"   (C2_plasma_membrane → ∅)
    • Reaction "C2_PI3K internalization"   (C2_PI3K_plasma_membrane → PI3K_cytosol)
    • Reaction "PI3K binding"   (C2_plasma_membrane + PI3K_cytosol → C2_PI3K_plasma_membrane)
    • Reaction "C2 uncoupling"   (C2_plasma_membrane → R_plasma_membrane + C1_plasma_membrane)
    • Reaction "activated PIP3 synthesis"   (∅ → PIP3_plasma_membrane)
  • Compartment "nuclear_membrane".   (type: Membrane)
    • Reaction "PI3K nuclear flux"   (PI3K_cytosol → PI3K_nucleus)
    • Reaction "GFP_AktPH nuclear flux"   (GFP_AktPH_cytosol → GFP_AktPH_nucleus)
2018-07-12T19:23:13+00:00 February 16th, 2018|biomodel|