Name: “hillelab: KruseVivasTraynorKaplanHille_PI-metabolism_SCG_2015”
Saved: Thu, 18 Feb 2016  18:45:21 GMT
vcell identifier: biomodel-98296160
Owned by: “mkruse”

download model (.vcml)

Compartments, Species, Reactions
  • Compartment "C".   (type: Volume)
    • Species "Ca_Buffer_high_aff"
    • Species "Ca_Buffer_high_aff_Ca"
    • Species "IP3R_IRBIT"
    • Species "IP3_PH_YFP_C"
    • Species "PH_YFP_C"
    • Species "K_C"
    • Species "Ca_Buffer_low_aff_Ca"
    • Species "P4M_dom_C"
    • Species "Ca_Fura2_C"
    • Species "IP3_LibraVIII_C"
    • Species "LibraVIII_C"
    • Species "Fura2_C"
    • Species "C1_dom_C"
    • Species "Ca_C"
    • Species "Palk_C1"
    • Species "IP3_C"
    • Species "Tubby_C"
    • Species "Palk_O4"
    • Species "Palk_C2"
    • Species "Palk_C3"
    • Species "Ca_Buffer_low_aff"
    • Species "IP3R_IP3"
    • Reaction "r24"   (Palk_C2 → Palk_O4)
    • Reaction "IP3R_IP3_binding"   (IP3_C + IP3R_IRBIT → IP3R_IP3)
    • Reaction "IP3deg_Palk"   (IP3_C → ∅)
    • Reaction "r12"   (Palk_C1 → Palk_C2)
    • Reaction "Cabind_Fura2"   (Ca_C + Fura2_C → Ca_Fura2_C)
    • Reaction "IP3_LibraVIII"   (IP3_C + LibraVIII_C → IP3_LibraVIII_C)
    • Reaction "IP3Pase_KVH"   (IP3_C → ∅)
    • Reaction "Ca_Buffering_low_aff"   (Ca_Buffer_low_aff + Ca_C → Ca_Buffer_low_aff_Ca)
    • Reaction "Ca_Buffering_high_aff"   (Ca_Buffer_high_aff + Ca_C → Ca_Buffer_high_aff_Ca)
    • Reaction "r23"   (Palk_C2 → Palk_C3)
    • Reaction "PH_YFP_IP3"   (PH_YFP_C + IP3_C → IP3_PH_YFP_C)
  • Compartment "Ca_store".   (type: Volume)
    • Species "Ca_Ca_store"
  • Compartment "EX".   (type: Volume)
    • Species "K_EX"
    • Species "OxoM_conc_EX"
    • Species "oxoM_EX"
    • Reaction "Oxo_appl"   (OxoM_conc_EX → oxoM_EX)
  • Compartment "M".   (type: Membrane)
    • Species "R_M"
    • Species "RLGbeta_M"
    • Species "RL_M"
    • Species "PH_YFP_PIP2_M"
    • Species "KCNQ_M"
    • Species "Tubby_PIP2_M"
    • Species "KCNQ_PIP2_M"
    • Species "boundPIP2_M"
    • Species "GaGDP_PLC_M"
    • Species "GaGTP_M"
    • Species "Gbeta_M"
    • Species "DAG_M"
    • Species "G_GDP_M"
    • Species "RG_GDP_M"
    • Species "PI_M"
    • Species "PA_2AG_M"
    • Species "PIP2_M"
    • Species "PI4P_M"
    • Species "GaGTP_PLC_M"
    • Species "RLG_GDP_M"
    • Species "Ga_GDP_M"
    • Species "PLC_M"
    • Species "RGbeta_M"
    • Species "C1_DAG_M"
    • Species "P4M_PI4P_M"
    • Reaction "PIP2_buffering"   (PIP2_M → boundPIP2_M)
    • Reaction "G2"   (RL_M + G_GDP_M → RLG_GDP_M)
    • Reaction "L2beta"   (oxoM_EX + RGbeta_M → RLGbeta_M)
    • Reaction "NE_RLG"   (RLG_GDP_M → RLGbeta_M + GaGTP_M)
    • Reaction "L1"   (oxoM_EX + R_M → RL_M)
    • Reaction "DAGPase"   (DAG_M → PA_2AG_M)
    • Reaction "PH_YFP_PIP2"   (PIP2_M + PH_YFP_C → PH_YFP_PIP2_M)
    • Reaction "PLCassoc"   (PLC_M + GaGTP_M → GaGTP_PLC_M)
    • Reaction "Tubby_PIP2"   (Tubby_C + PIP2_M → Tubby_PIP2_M)
    • Reaction "reconstitution"   (Gbeta_M + Ga_GDP_M → G_GDP_M)
    • Reaction "VSP"   (PIP2_M → PI4P_M)
    • Reaction "PIP2hydr"   (PIP2_M → IP3_C + DAG_M)
    • Reaction "GTPase_GaP"   (GaGTP_PLC_M → GaGDP_PLC_M)
    • Reaction "PIP5K_5Pase"   (PI4P_M → PIP2_M)
    • Reaction "C1bindDAG"   (DAG_M + C1_dom_C → C1_DAG_M)
    • Reaction "G2beta"   (Gbeta_M + RL_M → RLGbeta_M)
    • Reaction "PLC_on_PI4P"   (PI4P_M → DAG_M)
    • Reaction "L2"   (oxoM_EX + RG_GDP_M → RLG_GDP_M)
    • Reaction "PI4K"   (PI_M → PI4P_M)
    • Reaction "G1"   (G_GDP_M + R_M → RG_GDP_M)
    • Reaction "NE_RG"   (RG_GDP_M → GaGTP_M + RGbeta_M)
    • Reaction "NE_G"   (G_GDP_M → Gbeta_M + GaGTP_M)
    • Reaction "PI4Pase"   (PI4P_M → PI_M)
    • Reaction "P4M_bind_PI4P"   (P4M_dom_C + PI4P_M → P4M_PI4P_M)
    • Reaction "PLCdiss"   (GaGDP_PLC_M → PLC_M + Ga_GDP_M)
    • Reaction "GTPase_Ga"   (GaGTP_M → Ga_GDP_M)
    • Reaction "PIP2bindKCNQ"   (KCNQ_M + PIP2_M → KCNQ_PIP2_M)
    • Reaction "NE_GaP"   (GaGDP_PLC_M → GaGTP_PLC_M)
    • Reaction "G1beta"   (Gbeta_M + R_M → RGbeta_M)
    • Reaction "KCNQ2/3"   (K_EX → K_C)
  • Compartment "ERM".   (type: Membrane)
    • Species "noninactiveIP3R"
    • Species "inactiveIP3R"
    • Reaction "h_reaction_IP3Rinactivation"   (noninactiveIP3R → inactiveIP3R)
    • Reaction "SERCA_Palk"   (Ca_C → Ca_Ca_store)
    • Reaction "leak_Palk"   (Ca_C → Ca_Ca_store)
    • Reaction "SERCA_flux_KVH"   (Ca_C → Ca_Ca_store)
    • Reaction "IP3R_flux_KVH"   (Ca_C → Ca_Ca_store)
    • Reaction "ER_leak_flux_KVH"   (Ca_C → Ca_Ca_store)
    • Reaction "RyR_Palk"   (Ca_C → Ca_Ca_store)
    • Reaction "IP3R_Palk"   (Ca_C → Ca_Ca_store)