Name: “RS_JBC2016”
Saved: Thu, 29 Sep 2016  15:26:26 GMT
vcell identifier: biomodel-102802266
Owned by: “rsong”

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Compartments, Species, Reactions
  • Compartment "IC".   (type: Volume)
    • Species "PDE2_cGMP"
    • Species "PDE2_inhibited"
    • Species "Bay60"
    • Species "PDEbg_cGMP"
    • Species "GMP"
    • Species "PDE2_cAMP"
    • Species "GTP"
    • Species "sGC_basal"
    • Species "R2C2_cAMP"
    • Species "R2C2"
    • Species "R2C2_cAMP2"
    • Species "PKA"
    • Species "R2C_cAMP4"
    • Species "R2_cAMP4"
    • Species "R2C2_cAMP4"
    • Species "GluA1_845"
    • Species "Four1N"
    • Species "PDE1"
    • Species "GluA1"
    • Species "cAMP"
    • Species "PDE1_cGMP"
    • Species "R2C2_cAMP3"
    • Species "PDE2"
    • Species "cGMP"
    • Species "PDE2_active_cAMP"
    • Species "AMP"
    • Species "PDE2_active_cGMP"
    • Species "PDEbg_cAMP"
    • Species "PDE1_cAMP"
    • Species "DARPP32"
    • Species "DARPP32_Pi"
    • Species "DARPP32_Pi_PP1"
    • Species "PP2A"
    • Species "MMPX"
    • Species "PP1"
    • Species "ERK_active"
    • Species "PDE4_ERK"
    • Species "PDE4"
    • Species "PDE4_PKA"
    • Species "PDE4_ERK_PKA"
    • Species "PDE1_inhibited"
    • Species "ATP"
    • Species "BRaf"
    • Species "BRaf_PKA"
    • Species "MEK_active"
    • Species "MEK_Ser"
    • Species "MEK"
    • Species "ERK_Tyr"
    • Species "ERK"
    • Species "STEP"
    • Species "STEP_PKA"
    • Species "PDE2_active"
    • Species "SNAP"
    • Species "sGC_inactive"
    • Species "sGC_active"
    • Reaction "r097"   (STEP_PKA → STEP)
    • Reaction "r096"   (STEP → STEP_PKA)
    • Reaction "r093"   (ERK_active → ERK_Tyr)
    • Reaction "r094"   (ERK_Tyr → ERK)
    • Reaction "r027"   (PDE1_cAMP → PDE1 + AMP)
    • Reaction "r044"   (R2C2_cAMP4 → PKA + R2C_cAMP4)
    • Reaction "r073"   (DARPP32_Pi_PP1 → PP1 + DARPP32)
    • Reaction "r051"   (PDE1 + MMPX → PDE1_inhibited)
    • Reaction "r070"   (DARPP32 → DARPP32_Pi)
    • Reaction "r071"   (DARPP32_Pi + PP1 → DARPP32_Pi_PP1)
    • Reaction "r019"   (PDE2_active + cGMP → PDE2_active_cGMP)
    • Reaction "r054"   (PDE2 + Bay60 → PDE2_inhibited)
    • Reaction "r058"   (PDE2_active_cAMP + Bay60 → PDE2_inhibited)
    • Reaction "r029"   (PDE1_cGMP → GMP + PDE1)
    • Reaction "r059"   (PDE2_active_cGMP + Bay60 → PDE2_inhibited)
    • Reaction "r060"   (cGMP → GMP)
    • Reaction "r017"   (PDE2_cGMP → GMP + PDE2)
    • Reaction "r016"   (PDE2_cAMP → AMP + PDE2)
    • Reaction "r018"   (PDE2 + cAMP → PDE2_cAMP)
    • Reaction "r028"   (PDE1 + cGMP → PDE1_cGMP)
    • Reaction "r053"   (PDE1_cGMP + MMPX → PDE1_inhibited)
    • Reaction "r072"   (DARPP32_Pi → DARPP32)
    • Reaction "r026"   (PDE1 + cAMP → PDE1_cAMP)
    • Reaction "r052"   (PDE1_cAMP + MMPX → PDE1_inhibited)
    • Reaction "r011"   (PDE2 + cGMP → PDE2_active)
    • Reaction "r042"   (R2C2_cAMP2 + cAMP → R2C2_cAMP3)
    • Reaction "r085"   (BRaf → BRaf_PKA)
    • Reaction "r086"   (BRaf_PKA → BRaf)
    • Reaction "r087"   (MEK → MEK_Ser)
    • Reaction "r088"   (MEK_Ser → MEK_active)
    • Reaction "r091"   (ERK → ERK_Tyr)
    • Reaction "r089"   (MEK_active → MEK_Ser)
    • Reaction "r090"   (MEK_Ser → MEK)
    • Reaction "r092"   (ERK_Tyr → ERK_active)
    • Reaction "r095"   (ERK_Tyr → ERK)
    • Reaction "r047"   (GluA1_845 → GluA1)
    • Reaction "r075"   (PDE4 → PDE4_PKA)
    • Reaction "r077"   (PDE4_ERK → PDE4_ERK_PKA)
    • Reaction "r078"   (PDE4_ERK_PKA → PDE4)
    • Reaction "r080"   (PDE4_PKA → PDE4_ERK_PKA)
    • Reaction "r076"   (PDE4_ERK → PDE4)
    • Reaction "r079"   (PDE4_PKA → PDE4)
    • Reaction "r083"   (cAMP → AMP)
    • Reaction "r084"   (cAMP → AMP)
    • Reaction "r024"   (cAMP → AMP)
    • Reaction "r056"   (Bay60 + PDE2_cGMP → PDE2_inhibited)
    • Reaction "r074"   (PDE4 → PDE4_ERK)
    • Reaction "r081"   (cAMP → AMP)
    • Reaction "r012"   (cGMP + PDE2 → PDE2_cGMP)
    • Reaction "r046"   (GluA1 → GluA1_845)
    • Reaction "r082"   (cAMP → AMP)
    • Reaction "r057"   (PDE2_active + Bay60 → PDE2_inhibited)
    • Reaction "r055"   (Bay60 + PDE2_cAMP → PDE2_inhibited)
    • Reaction "r015"   (PDE2_active_cGMP → GMP + PDE2_active)
    • Reaction "r014"   (PDE2_active_cAMP → AMP + PDE2_active)
    • Reaction "r039"   (GTP → cGMP)
    • Reaction "r041"   (R2C2_cAMP + cAMP → R2C2_cAMP2)
    • Reaction "r045"   (R2C_cAMP4 → R2_cAMP4 + PKA)
    • Reaction "r013"   (PDE2_active + cAMP → PDE2_active_cAMP)
    • Reaction "r043"   (R2C2_cAMP3 + cAMP → R2C2_cAMP4)
    • Reaction "r040"   (cAMP + R2C2 → R2C2_cAMP)
    • Reaction "r098"   (sGC_inactive + SNAP → sGC_active)
    • Reaction "r099"   (GTP → cGMP)
  • Compartment "EC".   (type: Volume)
    • Species "DA"
  • Compartment "PM".   (type: Membrane)
    • Species "AMPAR"
    • Species "GluA1_dephos"
    • Species "Ga_GTP"
    • Species "D1R"
    • Species "Gaby"
    • Species "DA_D1R_Gaby"
    • Species "Gby"
    • Species "Ga_GDP"
    • Species "D1R_Gaby"
    • Species "DA_D1R"
    • Species "ACbg"
    • Species "AC5"
    • Species "AC5_Ga"
    • Reaction "r010"   (ATP → cAMP)
    • Reaction "r001"   (Gaby + D1R → D1R_Gaby)
    • Reaction "r048"   (Four1N + GluA1_845 → AMPAR)
    • Reaction "r005"   (DA_D1R_Gaby → Gby + Ga_GTP + DA_D1R)
    • Reaction "r002"   (D1R_Gaby + DA → DA_D1R_Gaby)
    • Reaction "r025"   (ATP → cAMP)
    • Reaction "r000"   (D1R + DA → DA_D1R)
    • Reaction "r049"   (AMPAR → GluA1_dephos)
    • Reaction "r050"   (GluA1_dephos → GluA1 + Four1N)
    • Reaction "r007"   (Ga_GTP + AC5 → AC5_Ga)
    • Reaction "r006"   (Ga_GTP → Ga_GDP)
    • Reaction "r009"   (ATP → cAMP)
    • Reaction "r004"   (Ga_GDP + Gby → Gaby)
    • Reaction "r003"   (DA_D1R + Gaby → DA_D1R_Gaby)