Name: “A predictive computational model reveals that GIV/Girdin serves as a tunable valve for EGFR-stimulated Cyclic AMP Signals”
Saved: Apr 30, 2019
vcell identifier: biomodel-156134818
Owned by: “mgetz”

download model (.vcml)

Compartments, Species, Reactions
  • Compartment "Endosome".   (type: Volume)
    • Species "EGFi"
    • Reaction "EGF_deg"   (EGFi → ∅)
  • Compartment "Cyto".   (type: Volume)
    • Species "PLCg"
    • Species "IP3"
    • Species "inositol"
    • Species "PKC"
    • Species "ATP"
    • Species "cAMP"
    • Species "PKA"
    • Species "PDE"
    • Species "R2C2"
    • Species "AMP"
    • Species "PDEp"
    • Species "PP_PDE"
    • Species "PLCg_active"
    • Species "GIV"
    • Species "GIV_GEF"
    • Species "GIV_GDI"
    • Species "Cdk5"
    • Species "R2"
    • Species "R2u"
    • Species "R2uu"
    • Species "PKA_inact"
    • Species "GIV89p"
    • Reaction "Degradation_GDI"   (GIV_GDI → GIV)
    • Reaction "Degradation_GEF"   (GIV_GEF → GIV)
    • Reaction "IP3_degradation"   (IP3 → inositol)
    • Reaction "PDE_phos"   (PDE → PDEp)
    • Reaction "PKA_inactivation"   (PKA → PKA_inact)
    • Reaction "PKA_reformation"   (R2uu + 2 PKA → R2C2)
    • Reaction "PLC_deactivation"   (PLCg_active → PLCg)
    • Reaction "R2uUnbind"   (R2u → R2uu + 2 cAMP)
    • Reaction "R2Unbind"   (R2 → R2u + 2 cAMP)
    • Reaction "cAMP_Activation"   (R2C2 + 4 cAMP → R2 + 2 PKA)
    • Reaction "cAMP_to_AMP"   (cAMP → AMP)
    • Reaction "cAMP_to_AMP_PDEp"   (cAMP → AMP)
    • Reaction "dephos_of_PDEp"   (PDEp → PDE)
    • Reaction "basalGIVGDI"   (GIV + Gs_GDP_i → Gs_GDI_b)
    • Reaction "_89pDEG"   (GIV89p → GIV)
  • Compartment "ECM".   (type: Volume)
    • Species "EGF"
  • Compartment "intmem".   (type: Membrane)
    • Species "AC_act"
    • Species "Gs_GTP_i"
    • Species "Gs_GDP_i"
    • Species "Gs_GDI_i"
    • Species "EGF_EGFR_i_act"
    • Species "AC_i"
    • Species "bg_i"
    • Species "EGFRi"
    • Species "EGF_EGFRi"
    • Species "EGF_EGFR_2i"
    • Species "Gs_protein_i"
    • Species "Gs_GDI_b"
    • Species "I"
    • Reaction "AC_activation"   (AC_i + Gs_GTP_i → AC_act)
    • Reaction "EGFR_deg"   (EGFRi → ∅)
    • Reaction "EGFR_to_PM"   (EGFRi → EGFR)
    • Reaction "GDI_function"   (GIV_GDI + Gs_GDP_i → Gs_GDI_i)
    • Reaction "Gs_GDI_accel_deg"   (EGF_EGFR_i_act → ∅)
    • Reaction "Gs_activation"   (Gs_protein_i → bg_i + Gs_GTP_i)
    • Reaction "Gs_hydrolysis"   (Gs_GTP_i → Gs_GDP_i)
    • Reaction "InactivAC"   (AC_act → AC_i + Gs_GDP_i)
    • Reaction "cAMP_basal_production_internal"   (ATP → cAMP)
    • Reaction "internal_trimerize"   (bg_i + Gs_GDP_i → Gs_protein_i)
    • Reaction "production_cAMP_internal"   (ATP → cAMP)
    • Reaction "v10"   (EGFi + EGFRi → EGF_EGFRi)
    • Reaction "v11"   (2 EGF_EGFRi → EGF_EGFR_2i)
    • Reaction "v12"   (EGF_EGFR_2i → EGF_EGFR_i_act)
    • Reaction "Gs_GDI_accel_deg_copy"   (Gs_GDI_i → ∅)
    • Reaction "Gs_GDI_accel_deg_copy2"   (Gs_GDP_i → ∅)
    • Reaction "Gs_GDI_accel_deg_copy3"   (Gs_GTP_i → ∅)
    • Reaction "Gs_GDI_accel_deg_copy4"   (AC_act → ∅)
    • Reaction "Gs_GDI_accel_deg_copy5"   (EGF_EGFRi → ∅)
    • Reaction "Gs_GDI_accel_deg_copy6"   (Gs_GDI_b → ∅)
    • Reaction "Intfun"   (∅ → I)
  • Compartment "PM".   (type: Membrane)
    • Species "EGFR"
    • Species "p35"
    • Species "p35_act"
    • Species "Gi_GTP"
    • Species "Gi_GDP"
    • Species "EGF_EGFR"
    • Species "PKC_act"
    • Species "AC"
    • Species "PIP2"
    • Species "EGF_EGFR_2_act"
    • Species "EGF_EGFR_2"
    • Species "DAG"
    • Species "GEF_EGFR"
    • Species "GEF_Gi_EGFR"
    • Species "AC_inact"
    • Species "Gs_protein"
    • Species "Cdk5_p35_act"
    • Reaction "AC_inactivation"   (AC + Gi_GTP → AC_inact)
    • Reaction "AC_internalization"   (AC → AC_i)
    • Reaction "AC_unbinding"   (AC_inact → AC + Gi_GDP)
    • Reaction "Cdk5_activation"   (Cdk5 + p35_act → Cdk5_p35_act)
    • Reaction "DAG_decactivation"   (DAG → ∅)
    • Reaction "DAG_deactivation_while_bound"   (PKC_act → PKC)
    • Reaction "Dimerize"   (2 EGF_EGFR → EGF_EGFR_2)
    • Reaction "Dimerized_receptor_activation"   (EGF_EGFR_2 → EGF_EGFR_2_act)
    • Reaction "EGFR_GEF_to_GDI"   (GEF_EGFR → GIV_GDI + EGF_EGFR_2_act)
    • Reaction "GEF_EGFR_binding"   (GIV_GEF + EGF_EGFR_2_act → GEF_EGFR)
    • Reaction "GEF_Gi_Binding"   (GEF_EGFR + Gi_GDP → GEF_Gi_EGFR)
    • Reaction "GEF_activation"   (GIV → GIV_GEF)
    • Reaction "GEF_to_GDI"   (GIV_GEF → GIV_GDI)
    • Reaction "Gi_activation"   (GEF_Gi_EGFR → GEF_EGFR + Gi_GTP)
    • Reaction "Gi_hydrolysis"   (Gi_GTP → Gi_GDP)
    • Reaction "Gs_internalization"   (Gs_protein → Gs_protein_i)
    • Reaction "PIP2_to_DAG"   (PIP2 → DAG + IP3)
    • Reaction "PKC_activation"   (PKC + DAG → PKC_act)
    • Reaction "PLC_GEF_enhanced"   (PLCg → PLCg_active)
    • Reaction "PLC_activation_basal"   (PLCg → PLCg_active)
    • Reaction "cAMP_basal"   (ATP → cAMP)
    • Reaction "internal_transport"   (EGF_EGFR_2_act → EGF_EGFR_i_act)
    • Reaction "p35_activation"   (p35 → p35_act)
    • Reaction "p35_inactivation"   (p35_act → p35)
    • Reaction "receptor_ligand_binding"   (EGF + EGFR → EGF_EGFR)
2019-07-11T15:13:14+00:00 June 15th, 2019|biomodel|