2020-08-05. The 2020 Computational Cell Biology Workshop was held as an online event Aug 3-5. Find videos of the key presentations here. Over 70 individuals participated overall; 16 individuals created models with VCell, COPASI and SpringSaLaD with help from CCAM team members in breakout rooms. A screen shot of one the opening day presentations serves in place of our traditional group photo this year.
2020-04-07. A new spatial model of the PLC/PKC pahtway created in VCell was used to explore chemotactic sensing in fibroblasts in a new publication by Nosbisch et al from the Haugh lab. Visit our published models page for links to the paper and the VCell model.
Mechanistic Models of PLC/PKC Signaling Implicate Phosphatidic Acid as a Key Amplifier of Chemotactic Gradient Sensing.
Nosbisch, J.L., A. Rahman, M. Krithika, T.C. Elston, J.E. Bear, and J. M. Haugh
PLoS Comput. Biol. 16(4):e1007708
PUBMED:32255775
doi:10.1371/journal.pcbi.1007708
VCell BioModels referenced in publication:
user: jnosbis, model name: Nosbisch chemotaxis 2020
Name: “Nobisch chemotaxis 2020”
Saved: Jan 30, 2019
vcell identifier: biomodel-172076998
Owned by: “jnosbis”
Name: “Monkeyflower_pigmentation_v2”
Saved: Nov 13, 2019
vcell identifier: biomodel-169993006
Owned by: “colreeze”
Two MYB Proteins in a Self-Organizing Activator-Inhibitor System Produce Spotted Pigmentation Patterns.
Ding, B., E.L. Patterson, S.V. Holalu, J. Li, G.A. Johnson, L.E. Stanley, A.B. Greenlee, F. Peng, H.D. Bradshaw, M.L. Blinov, B.K. Blackman, and Y.-W. Yuan
Current Biology. 30:802-814.e8
PUBMED:32155414
doi:10.1016/j.cub.2019.12.067
VCell BioModels referenced in publication:
user: colreeze, model name: Monkeyflower_pigmentation_v2
2020-03-09. A new VCell model is used to explore how MYB proteins form an activator-inhibitor system that defines the spot pattern in mokeyflower petals. Visit our published models page for links to the paper and the VCell model.
2020-01-30. A VCell model is used in a new paper by Dreyer and Michard to re-examine the concept of high- and low-affinity nutrient uptade systems in plants. Visit our published models page for links to the paper.
High- and Low-Affinity Transport in Plants From a Thermodynamic Point of View.
Dreyer, I., and E. Michard
Front. Plant Sci. 10: 17497.
PUBMED:32082350
doi:10.3389/fpls.2019.01797
2019-12-10. VCell 7.2 has been released. See the Release Notes for a full list of the many new features in VCell 7.2 including new functionality to store identifiers and text annotations for model components, a service linking VCell simulation with ImageJ image analysis functions, rate rules and assignment rules in ODE applications, improved SBML import along with several other improvements.
