Due to an unexpected failure, VCell model simulation results from 2019 and earlier cannot currently be accessed. All other VCell functions are unaffected, so saving new models and running simulations and storing results on our servers will function normally. We expect the situation to be corrected within a few days, and all simulation results will once again be available from our archival storage. Our apologies for any inconvenience.
2020-08-05. The 2020 Computational Cell Biology Workshop was held as an online event Aug 3-5. Find videos of the key presentations here. Over 70 individuals participated overall; 16 individuals created models with VCell, COPASI and SpringSaLaD with help from CCAM team members in breakout rooms. A screen shot of one the opening day presentations serves in place of our traditional group photo this year.
2020-04-07. A new spatial model of the PLC/PKC pahtway created in VCell was used to explore chemotactic sensing in fibroblasts in a new publication by Nosbisch et al from the Haugh lab. Visit our published models page for links to the paper and the VCell model.
Mechanistic Models of PLC/PKC Signaling Implicate Phosphatidic Acid as a Key Amplifier of Chemotactic Gradient Sensing.
Nosbisch, J.L., A. Rahman, M. Krithika, T.C. Elston, J.E. Bear, and J. M. Haugh
PLoS Comput. Biol. 16(4):e1007708
PUBMED:32255775
doi:10.1371/journal.pcbi.1007708
VCell BioModels referenced in publication:
user: jnosbis, model name: Nosbisch chemotaxis 2020
Name: “Nobisch chemotaxis 2020”
Saved: Jan 30, 2019
vcell identifier: biomodel-172076998
Owned by: “jnosbis”
Name: “Monkeyflower_pigmentation_v2”
Saved: Nov 13, 2019
vcell identifier: biomodel-169993006
Owned by: “colreeze”
Two MYB Proteins in a Self-Organizing Activator-Inhibitor System Produce Spotted Pigmentation Patterns.
Ding, B., E.L. Patterson, S.V. Holalu, J. Li, G.A. Johnson, L.E. Stanley, A.B. Greenlee, F. Peng, H.D. Bradshaw, M.L. Blinov, B.K. Blackman, and Y.-W. Yuan
Current Biology. 30:802-814.e8
PUBMED:32155414
doi:10.1016/j.cub.2019.12.067
VCell BioModels referenced in publication:
user: colreeze, model name: Monkeyflower_pigmentation_v2
2020-03-09. A new VCell model is used to explore how MYB proteins form an activator-inhibitor system that defines the spot pattern in mokeyflower petals. Visit our published models page for links to the paper and the VCell model.
2020-01-30. A VCell model is used in a new paper by Dreyer and Michard to re-examine the concept of high- and low-affinity nutrient uptade systems in plants. Visit our published models page for links to the paper.
High- and Low-Affinity Transport in Plants From a Thermodynamic Point of View.
Dreyer, I., and E. Michard
Front. Plant Sci. 10: 17497.
PUBMED:32082350
doi:10.3389/fpls.2019.01797
