2026-06-05. 28th Annual On-site Workshop Computational Cell Biology took place at the Center for Cell Analysis and Modeling on June 1-3. Eight participants from different US universities (John Hopkins, Purdue, University of Tennessee and University of Connecticut) came for three days to learn VCell, COPASI and SpringSaLaD and develop projects under the guidance of our modelers.
2026-05-27. The new major VCell release (8.0) added SpringSaLaD (Michalski & Loew, 2016) as a fully supported VCell Applications. SpringSaLaD enables spatial, stochastic, particle-based simulation of reaction-diffusion systems, representing biomolecules as collections of linked spherical sites with explicit excluded-volume interactions in three-dimensional space — bridging detailed molecular-dynamics and cellular-level reaction-network modeling.
2026-02-03. The new VCell release (7.7.0 build 47) does not need admin priviledges to install. To switch to a new version, a user still need admin priviledges to uninstall the previous version, but from now on, local users will be able to run VCell no asking fro help from sysadmin. If you have problems, manually remove VCell from your computer, and download a new one from https://vcell.org/run-vcell-software.
2026-02-03. Researchers at UConn, UPitt and U Virginia used VCell to model systems-level consequences of low RAF abundance for EGFR-ERK signaling
Biophysical Journal. 2026 Feb 3;125(3):881-900.
https://pubmed.ncbi.nlm.nih.gov/41496453/
2025-12-10. VCell was represented at the American Society of Cell Biology Annual Meeting 2025 in Philaderplphia. On Sunday, December 7th, Michael Blinov together with James Faeder (UPitt) and Margaret Johnson (JHU) presented rule-base modeling methods for Biophysical Modeling of the Cell, including VCell. On Monday, December 8th, Pedro Mendes, Leslie Loew, Ion Moraru, and Michael Blinov presented various modeling techniques using COPASI, VCell and SpringSaLaD during the workshop on Mathematical Modeling for Cell Biology. […]
2025-11-19. Researchers at several Japanase Universities used VCell to model graded regulation of microtubule-binding of Tau by the phosphorylation state of the proline-rich region in living neurons:
Nakata, R., Torii, T., Miyasaka, T. and Misonou, H., 2025. Graded regulation of microtubule-binding of Tau by the phosphorylation state of the proline-rich region in living neurons. Neuroscience Research, p.104987.
https://pubmed.ncbi.nlm.nih.gov/41265727/
2025-10-23. Researchers at UConn and University of Cambridge (UK) used VCell to model FRAP in their studies of resistance and germination of spores of Bacillus species lacking members of a spore integral inner membrane protein family and locations of these proteins in spores
Journal of Bacteriology. 2025 Oct 23;207(10):e00217-25.
https://pubmed.ncbi.nlm.nih.gov/40938645/
2025-10-17. Researchers at UConn Health used VCell to aid in detection of dedifferentiated stem cells in the Drosophila testis.
Iscience. 2025 Oct 17;28(10).
https://pubmed.ncbi.nlm.nih.gov/41142995/
2025-10-12. Douglas Lin & Michael Martin from University of Louisville created a multicellular simulator implementing the Gillespie algorithm and compatible with Virtual Cell-designed networks to investigate a role of intercellular interactions on single cell and population level responses
Front Mol Biosci, 13:12:1595363. doi: 10.3389/fmolb.2025.1595363. eCollection 2025
https://pubmed.ncbi.nlm.nih.gov/41158874/
2025-10-09. VCell was presented at the International Conference on Systems Biology ICSB 2025 in Dublin, Ireland. A poster was presented by Michael Blinov describing the recent advances in VCell.
