News

2025-03-09. Alberto Millan from Kite Corp and Lewis Lanier from UCSF published a study on ITAM-mediated human Natural killer cells signaling. VCell was used to create a rule-based model in .bngl (BioNetGen) format.
Millan, A. J., Allain, V., Nayak, I., Libang, J. B., Quijada-Madrid, L. M., Arakawa-Hoyt, J. S., … & Lanier, L. L. (2025). SYK negatively regulates ITAM-mediated human NK cell signaling and CD19-CAR NK cell efficacy. The Journal of Immunology, vkaf012
https://pubmed.ncbi.nlm.nih.gov/40073103/

2025-02-28. The 26th Computational Cell Biology workshop took place ONLINE for the 5 days, February 24-28th. Cell biologists and biophysicists leaned how to use VCell (https://vcell.org/) and SpringSalad (https://vcell.org/ssalad) software to develop spatial and non-spatial models using deterministic, stochastic, agent- and rule-based approaches.

2024-12-18. VCell was represented at the American Society of Cell Biology Annual Meeting 2024 in San Diego. Michael Blinov and Margaret Johnson (John Hopkins University) led the session on Biophysical Modeling of the Cell on December 14th. On December 15th, Leslie Loew, Ann Cowan, Stephan Hoops (U Virginia) taught COPASI and VCell tutorials during the workshop on
Mathematical Modeling for Cell Biology.

2024-11-08. The team of researchers from John Hopkins University used spatial modeling with VCell to analyze the role of Myosin II and cortexillin I assembly within the mechanoresponsive mechanism grounded in experimentally measured parameters.
Dolgitzer, D., Plaza-Rodríguez, A. I., Iglesias, M. A., Jacob, M. A. C., Todd, B., Robinson, D. N., & Iglesias, P. A. (2024). A continuum model of mechanosensation based on contractility kit assembly. Biophysical Journal. Nov 8:S0006-3495(24)00708-2.
https://pubmed.ncbi.nlm.nih.gov/39521955/

2024-06-10. The team of researchers from Michigan State University used reaction-diffusion modeling with VCell to provide insights into biophysical carbon concentrating mechanisms in land plants.
Kaste, J. A., Walker, B. J., & Shachar-Hill, Y. (2024). Reaction-diffusion modeling provides insights into biophysical carbon concentrating mechanisms in land plants. Plant Physiology, kiae324.
https://pubmed.ncbi.nlm.nih.gov/38857179/

2024-05-14. The team of researchers from Australia and Johns Hopkins University used VCell to design and simulate a model explaining the formation of endocytic nanoclusters driven by distinct recruitment of Dynamin1 long- and short-tail isoforms.
Jiang, A., Kudo, K., Gormal, R.S., Ellis, S., Guo, S., Wallis, T.P., Longfield, S.F., Robinson, P.J., Johnson, M.E., Joensuu, M. and Meunier, F.A., 2024. Dynamin1 long-and short-tail isoforms exploit distinct recruitment and spatial patterns to form endocytic nanoclusters. Nature Communications, 15(1), p.4060.
https://pubmed.ncbi.nlm.nih.gov/38017688/ […]

2024-02-12. Ingo Dreyer (U Talca, Chile) and Kai Konrad (U Wuerzburg, Germany) used VCell to design and simulate a model explaining the properties of transporter networks and the coupling of transport across the PM and VM. They demonstrated fundamental principles of coupled ion transport at membrane sandwiches to control H+ /K+ homeostasis and points to transceptor-like Ca²⁺ /H⁺ -based ion signaling in plant cells.
Kunkun Li, Christina Grauschopf, Rainer Hedrich, Ingo Dreyer, Kai R Konrad (2024). […]