2026-02-03. The new VCell release (7.7.0 build 47) does not need admin priviledges to install. To switch to a new version, a user still need admin priviledges to uninstall the previous version, but from now on, local users will be able to run VCell no asking fro help from sysadmin. If you have problems, manually remove VCell from your computer, and download a new one from https://vcell.org/run-vcell-software.
2026-02-03. Researchers at UConn, UPitt and U Virginia used VCell to model systems-level consequences of low RAF abundance for EGFR-ERK signaling
Biophysical Journal. 2026 Feb 3;125(3):881-900.
https://pubmed.ncbi.nlm.nih.gov/41496453/
2025-12-10. VCell was represented at the American Society of Cell Biology Annual Meeting 2025 in Philaderplphia. On Sunday, December 7th, Michael Blinov together with James Faeder (UPitt) and Margaret Johnson (JHU) presented rule-base modeling methods for Biophysical Modeling of the Cell, including VCell. On Monday, December 8th, Pedro Mendes, Leslie Loew, Ion Moraru, and Michael Blinov presented various modeling techniques using COPASI, VCell and SpringSaLaD during the workshop on Mathematical Modeling for Cell Biology. […]
2025-10-23. Researchers at UConn and University of Cambridge (UK) used VCell to model FRAP in their studies of resistance and germination of spores of Bacillus species lacking members of a spore integral inner membrane protein family and locations of these proteins in spores
Journal of Bacteriology. 2025 Oct 23;207(10):e00217-25.
https://pubmed.ncbi.nlm.nih.gov/40938645/
2025-10-12. Douglas Lin & Michael Martin from University of Louisville created a multicellular simulator implementing the Gillespie algorithm and compatible with Virtual Cell-designed networks to investigate a role of intercellular interactions on single cell and population level responses
Front Mol Biosci, 13:12:1595363. doi: 10.3389/fmolb.2025.1595363. eCollection 2025
https://pubmed.ncbi.nlm.nih.gov/41158874/
2025-10-09. VCell was presented at the International Conference on Systems Biology ICSB 2025 in Dublin, Ireland. A poster was presented by Michael Blinov describing the recent advances in VCell.
2025-09-20. VCell was used for teaching a short course on Systems Biology at Vytautas Magnus University – a leading public university in Lithuania. Michael Blinov was invited to give an intense 2 weeks course of 10 three-hour lectures every day. Many lectures featured Virtual VCell.
2025-03-18. Network-free simulations in VCell were used by U Toronto team led by Jonathan Ditlev to investigate how protein interactions, calcium, phosphorylation, and cholesterol modulate CFTR cluster formation on membranes. PNAS. 2025 Mar 18;122(11):e2424470122.
https://pubmed.ncbi.nlm.nih.gov/40063811/
2025-03-09. Alberto Millan from Kite Corp and Lewis Lanier from UCSF published a study on ITAM-mediated human Natural killer cells signaling. VCell was used to create a rule-based model in .bngl (BioNetGen) format.
Millan, A. J., Allain, V., Nayak, I., Libang, J. B., Quijada-Madrid, L. M., Arakawa-Hoyt, J. S., … & Lanier, L. L. (2025). SYK negatively regulates ITAM-mediated human NK cell signaling and CD19-CAR NK cell efficacy. The Journal of Immunology, vkaf012
https://pubmed.ncbi.nlm.nih.gov/40073103/
2025-02-28. The 26th Computational Cell Biology workshop took place ONLINE for the 5 days, February 24-28th. Cell biologists and biophysicists leaned how to use VCell (https://vcell.org/) and SpringSalad (https://vcell.org/ssalad) software to develop spatial and non-spatial models using deterministic, stochastic, agent- and rule-based approaches.
