About Michael Blinov

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So far Michael Blinov has created 46 blog entries.

VCell at ICSB 2023

2023-11-11T19:49:55+00:00 October 12th, 2023|News|

VCell was highlighted at the 22nd International Conference on Systems Biology (ICSB) that took place in Hartford October 8-12, 2023. The meeting was organized by CCAM faculty and co-chaired by Pedro Mendes and Ion Moraru. VCell team presented two tutorials (basic modeling by Ann Cowan and advanced features by Michael Blinov) and a poster.

A model of the cadherin-11 and PDGFR pathways crosstalk

2023-11-11T19:34:58+00:00 September 22nd, 2023|News|

2023-09-22. VCell collaborator Aurélie Carlier from Maastricht University published a manuscript where a computational model in VCell was used to represent the experimentally proven interactions between cadherin-11 and the two PDGFRs. The authors demonstrated the existence of a crosstalk between β-catenin (downstream to cadherin-11) and an ERK inhibitor protein (e.g. DUSP1).
Karagöz, Z., Passanha, F. R., Robeerst, L., van Griensven, M., LaPointe, V. L., & Carlier, A. (2023). Computational evidence for multi-layer crosstalk between the cadherin-11 and […]

Appalabhotla et al., 2023

2023-09-14T17:14:59+00:00 September 14th, 2023|publication, publication-2023|

G-actin diffusion is insufficient to achieve F-actin assembly in fast-treadmilling protrusions.
Appalabhotla, R., Butler, M. T., Bear, J. E., & Haugh, J. M.
Biophys J. 2023 Aug 28;S0006-3495(23)00553-2.
doi: 10.1016/j.bpj.2023.08.022
VCell BioModels referenced in the publication
user: ra_mb_jb_jmh
biomodel name: Figure 4
biomodel name: Figure 6 – Cytochalasin D Simulations
biomodel name: Figure S1 – G-actin diffusion 3D
biomodel name: Figure S4
biomodel name: Figure S5
mathmodel name: Figure 3 – Simulation Image and Line Scan; Figure 5 – Leading Edge Recovery and Line […]