VCell was highlighted at the 22nd International Conference on Systems Biology (ICSB) that took place in Hartford October 8-12, 2023. The meeting was organized by CCAM faculty and co-chaired by Pedro Mendes and Ion Moraru. VCell team presented two tutorials (basic modeling by Ann Cowan and advanced features by Michael Blinov) and a poster.
2023-09-22. VCell collaborator Aurélie Carlier from Maastricht University published a manuscript where a computational model in VCell was used to represent the experimentally proven interactions between cadherin-11 and the two PDGFRs. The authors demonstrated the existence of a crosstalk between β-catenin (downstream to cadherin-11) and an ERK inhibitor protein (e.g. DUSP1).
Karagöz, Z., Passanha, F. R., Robeerst, L., van Griensven, M., LaPointe, V. L., & Carlier, A. (2023). Computational evidence for multi-layer crosstalk between the cadherin-11 and […]
Computational evidence for multi-layer crosstalk between the cadherin-11 and PDGFR pathways.
Karagöz, Z., Passanha, F. R., Robeerst, L., van Griensven, M., LaPointe, V. L. S., Carlier, A.
Sci Rep 13, 15804 2023.
PUBMED:37737289
doi: 10.1038/s41598-023-42624-x
VCell BioModels referenced in the publication
user: ra_mb_jb_jmh
biomodel name: cdh11-pdgfr-erk-feedback-v2
Name: “Figure S5”
Saved: Sep 10, 2023
vcell identifier: biomodel-260473891
Owned by: “ra_mb_jb_jmh”
Name: “Figure S4”
Saved: Sep 10, 2023
vcell identifier: biomodel-260473574
Owned by: “ra_mb_jb_jmh”
Name: “Figure S1 – G-actin diffusion 3D”
Saved: Sep 10, 2023
vcell identifier: biomodel-260475137
Owned by: “ra_mb_jb_jmh”
Name: “Figure 6 – Cytochalasin D Simulations”
Saved: Aug 28, 2023
vcell identifier: biomodel-259882744
Owned by: “ra_mb_jb_jmh”
Name: “Figure 4”
Saved: Aug 28, 2023
vcell identifier: biomodel-259882394
Owned by: “ra_mb_jb_jmh”
G-actin diffusion is insufficient to achieve F-actin assembly in fast-treadmilling protrusions.
Appalabhotla, R., Butler, M. T., Bear, J. E., & Haugh, J. M.
Biophys J. 2023 Aug 28;S0006-3495(23)00553-2.
PUBMED:37644720
doi: 10.1016/j.bpj.2023.08.022
VCell BioModels referenced in the publication
user: ra_mb_jb_jmh
biomodel name: Figure 4
biomodel name: Figure 6 – Cytochalasin D Simulations
biomodel name: Figure S1 – G-actin diffusion 3D
biomodel name: Figure S4
biomodel name: Figure S5
mathmodel name: Figure 3 – Simulation Image and Line Scan; Figure 5 – Leading Edge Recovery and Line […]
2023-08-28. VCell collaborator Jason Haugh from North Carolina State University published a manuscript where experiments and VCell modeling demonstrated that G-actin diffusion is insufficient to achieve F-actin assembly in fast-treadmilling protrusions.
Appalabhotla, R., Butler, M.T., Bear, J.E. and Haugh, J.M. G-actin diffusion is insufficient to achieve F-actin assembly in fast-treadmilling protrusions. Biophys J. 2023 Aug 28;S0006-3495(23)00553-2. doi: 10.1016/j.bpj.2023.08.022. https://pubmed.ncbi.nlm.nih.gov/37644720/
See 5 biomodels and 14 mathmodels at https://vcell.org/appalabhotla-2023
