2023-05-01. VCell 7.5 has been released. It features parameter estimation from the latest version of COPASI; model exchange via multiple standards, including, SBML, SEDML and OMEX; parameter scans in local client simulations; and hardening of unit handling including automatic unit transformations. Full specs available https://vcell.org/run-vcell-software.
Expression of the 2Duf protein in wild-type Bacillus subtilis spores stabilizes inner membrane proteins and increases spore resistance to wet heat and hydrogen peroxide.
Korza G, DePratti S, Fairchild D, Wicander J, Kanaan J, Shames H, Nichols FC, Cowan A, Brul S, Setlow P.
Journal of Applied Microbiology. 2023 Mar 1;134(3):lxad040.
PUBMED:36841229
doi:10.1093/jambio/lxad040
VCell BioModels referenced in publication
user: dfairchild
biomodel name: Bacillus Spore Membrane FRAP Analysis
2023-03-01.VCell was used to demonstrate that expression of the 2Duf protein in wild-type Bacillus subtilis spores stabilizes inner membrane proteins and increases spore resistance to wet heat and hydrogen peroxide. Find links to the paper on our published models page.
2023-02-20. The VCell team presented a poster at the Biophysical Society Annual Meeting in San Diego (https://www.biophysics.org/2023meeting#/).
2023-02-13. The 24th Annual Computational Cell Biology workshop was sponsored by Cell Analysis and Modeling Center at the UConn Health on February 13-15th. It was an intense online event designed to enable cell biologists and biphysicists to develop mathematical models of their experimental systems.Keynote speakers included Jason Haugh, Pablo Iglesias and Ursula Kummer.
Optimization of Media Change Intervals through Hydrogels Using Mathematical Models.
Ruiter FA, King J, Swapnasrita S, Giselbrecht S.
Biomacromolecules. 2023 Feb 13;24(2):604-612.
PUBMED:36724373
doi:10.1021/acs.biomac.2c00961
Methodology for development of single cell dendritic spine (SCDS) synaptic tagging and capture model using Virtual Cell (VCell).
Khan R, Kulasiri D, Samarasinghe S.
MethodsX. 2023 Feb 11;10:102070.
PUBMED:36879764
doi:10.1016/j.mex.2023.102070
A multifarious exploration of synaptic tagging and capture hypothesis in synaptic plasticity: Development of an integrated mathematical model and computational experiments.
Khan R, Kulasiri D, Samarasinghe S.
Journal of Theoretical Biology. 2022 Oct 21:111326.
PUBMED:36279957
doi:10.1016/j.jtbi.2022.111326
Asynchronous glutamate release is enhanced in low release efficacy synapses and dispersed across the active zone.
Mendonça PR, Tagliatti E, Langley H, Kotzadimitriou D, Zamora-Chimal CG, Timofeeva Y, Volynski KE.
Nature communications. 2022 Jun 17;13(1):1-7.
PUBMED:35715404
doi:10.1038/s41467-022-31070-4
Purification and characterization of sequential cobalamin-dependent radical SAM methylases ThnK and TokK in carbapenem β-lactam antibiotic biosynthesis.
Sinner EK, Townsend CA.
Methods in Enzymology. 2022; 669:29–44
PUBMED:35644176
https://doi.org/10.1016/bs.mie.2021.09.014
