About Michael Blinov

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So far Michael Blinov has created 55 blog entries.

VCell 7.5 Release

2023-05-01T23:22:29+00:00 May 1st, 2023|News|

2023-05-01. VCell 7.5 has been released. It features parameter estimation from the latest version of COPASI; model exchange via multiple standards, including, SBML, SEDML and OMEX; parameter scans in local client simulations; and hardening of unit handling including automatic unit transformations. Full specs available https://vcell.org/run-vcell-software.

Korza et al., 2023

2023-05-12T20:27:47+00:00 March 12th, 2023|publication, publication-2022|

Expression of the 2Duf protein in wild-type Bacillus subtilis spores stabilizes inner membrane proteins and increases spore resistance to wet heat and hydrogen peroxide.
Korza G, DePratti S, Fairchild D, Wicander J, Kanaan J, Shames H, Nichols FC, Cowan A, Brul S, Setlow P.
Journal of Applied Microbiology. 2023 Mar 1;134(3):lxad040.
PUBMED:36841229
doi:10.1093/jambio/lxad040
VCell BioModels referenced in publication
user: dfairchild
biomodel name: Bacillus Spore Membrane FRAP Analysis

A model of relationships between Ca2+ and YAP/TAZ signalling

2024-03-17T02:57:36+00:00 February 16th, 2023|News|

2023-02-16. VCell collaborator Padmini Rangamani from University of California San Diego published a manuscript where a computational model of a mechanisms underlying divergent relationships between Ca2+ and YAP/TAZ signallingin was designed in VCell. The created system of ODEs was exported into MatLab for further simulations and processing.The model predicts context-dependent Ca2+ transient, CaMKII bistable response and frequency-dependent activation of LATS1/2 upstream regulators as mechanisms governing the Ca2+ -YAP/TAZ relationship.
Khalilimeybodi, A., Fraley, S. I., & Rangamani, […]

2023 Computational Cell Biology workshop

2023-03-09T01:24:18+00:00 February 13th, 2023|News|

2023-02-13. The 24th Annual Computational Cell Biology workshop was sponsored by Cell Analysis and Modeling Center at the UConn Health on February 13-15th. It was an intense online event designed to enable cell biologists and biphysicists to develop mathematical models of their experimental systems.Keynote speakers included Jason Haugh, Pablo Iglesias and Ursula Kummer.