2023-03-01.VCell was used to demonstrate that expression of the 2Duf protein in wild-type Bacillus subtilis spores stabilizes inner membrane proteins and increases spore resistance to wet heat and hydrogen peroxide. Find links to the paper on our published models page.
2023-02-20. The VCell team presented a poster at the Biophysical Society Annual Meeting in San Diego (https://www.biophysics.org/2023meeting#/).
Mechanisms underlying divergent relationships between Ca2+ and YAP/TAZ signalling.
Khalilimeybodi, A., Fraley, S.I. & Rangamani, P.
J Physiol. 2023 Feb;601(3): 483-515.
PUBMED:36463416
doi:10.1113/JP283966
VCell BioModels referenced in the publication
user: prangamani
biomodel name: Khalilimeybodi et al. 2022 J Physiol
2023-02-16. VCell collaborator Padmini Rangamani from University of California San Diego published a manuscript where a computational model of a mechanisms underlying divergent relationships between Ca2+ and YAP/TAZ signallingin was designed in VCell. The created system of ODEs was exported into MatLab for further simulations and processing.The model predicts context-dependent Ca2+ transient, CaMKII bistable response and frequency-dependent activation of LATS1/2 upstream regulators as mechanisms governing the Ca2+ -YAP/TAZ relationship.
Khalilimeybodi, A., Fraley, S. I., & Rangamani, […]
Name: “Khalilimeybodi et al. 2022 J Physiol”
Saved: Mar 15, 2024
vcell identifier: biomodel-269930396
Owned by: “prangamani”
2023-02-13. The 24th Annual Computational Cell Biology workshop was sponsored by Cell Analysis and Modeling Center at the UConn Health on February 13-15th. It was an intense online event designed to enable cell biologists and biphysicists to develop mathematical models of their experimental systems.Keynote speakers included Jason Haugh, Pablo Iglesias and Ursula Kummer.
Optimization of Media Change Intervals through Hydrogels Using Mathematical Models.
Ruiter FA, King J, Swapnasrita S, Giselbrecht S.
Biomacromolecules. 2023 Feb 13;24(2):604-612.
PUBMED:36724373
doi:10.1021/acs.biomac.2c00961
Methodology for development of single cell dendritic spine (SCDS) synaptic tagging and capture model using Virtual Cell (VCell).
Khan R, Kulasiri D, Samarasinghe S.
MethodsX. 2023 Feb 11;10:102070.
PUBMED:36879764
doi:10.1016/j.mex.2023.102070
A multifarious exploration of synaptic tagging and capture hypothesis in synaptic plasticity: Development of an integrated mathematical model and computational experiments.
Khan R, Kulasiri D, Samarasinghe S.
Journal of Theoretical Biology. 2022 Oct 21:111326.
PUBMED:36279957
doi:10.1016/j.jtbi.2022.111326
Asynchronous glutamate release is enhanced in low release efficacy synapses and dispersed across the active zone.
Mendonça PR, Tagliatti E, Langley H, Kotzadimitriou D, Zamora-Chimal CG, Timofeeva Y, Volynski KE.
Nature communications. 2022 Jun 17;13(1):1-7.
PUBMED:35715404
doi:10.1038/s41467-022-31070-4
