Michael Blinov – Page 5 – VCell- Modeling & Analysis Software

About Michael Blinov

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So far Michael Blinov has created 60 blog entries.

A model of relationships between Ca2+ and YAP/TAZ signalling

Michael Blinov 2024-03-17T02:57:36+00:00 February 16th, 2023|News|

2023-02-16. VCell collaborator Padmini Rangamani from University of California San Diego published a manuscript where a computational model of a mechanisms underlying divergent relationships between Ca2+ and YAP/TAZ signallingin was designed in VCell. The created system of ODEs was exported into MatLab for further simulations and processing.The model predicts context-dependent Ca2+ transient, CaMKII bistable response and frequency-dependent activation of LATS1/2 upstream regulators as mechanisms governing the Ca2+ -YAP/TAZ relationship.
Khalilimeybodi, A., Fraley, S. I., & Rangamani, […]

biomodel-269930396

Michael Blinov 2024-03-17T02:26:06+00:00 February 16th, 2023|biomodel|

Name: “Khalilimeybodi et al. 2022 J Physiol”
Saved: Mar 15, 2024
vcell identifier: biomodel-269930396
Owned by: “prangamani”

download model (.vcml)

2023 Computational Cell Biology workshop

Michael Blinov 2023-03-09T01:24:18+00:00 February 13th, 2023|News|

2023-02-13. The 24th Annual Computational Cell Biology workshop was sponsored by Cell Analysis and Modeling Center at the UConn Health on February 13-15th. It was an intense online event designed to enable cell biologists and biphysicists to develop mathematical models of their experimental systems.Keynote speakers included Jason Haugh, Pablo Iglesias and Ursula Kummer.

Ruiter et al., 2023

Michael Blinov 2023-03-09T02:02:50+00:00 February 1st, 2023|publication, publication-2022|

Optimization of Media Change Intervals through Hydrogels Using Mathematical Models.
Ruiter FA, King J, Swapnasrita S, Giselbrecht S.
Biomacromolecules. 2023 Feb 13;24(2):604-612.
PUBMED:36724373
doi:10.1021/acs.biomac.2c00961

Khan et al., 2023

Michael Blinov 2023-03-09T01:52:47+00:00 January 7th, 2023|publication, publication-2022|

Methodology for development of single cell dendritic spine (SCDS) synaptic tagging and capture model using Virtual Cell (VCell).
Khan R, Kulasiri D, Samarasinghe S.
MethodsX. 2023 Feb 11;10:102070.
PUBMED:36879764
doi:10.1016/j.mex.2023.102070

Khan et al., 2022

Michael Blinov 2022-11-22T21:22:12+00:00 November 22nd, 2022|publication, publication-2022|

A multifarious exploration of synaptic tagging and capture hypothesis in synaptic plasticity: Development of an integrated mathematical model and computational experiments.
Khan R, Kulasiri D, Samarasinghe S.
Journal of Theoretical Biology. 2022 Oct 21:111326.
PUBMED:36279957
doi:10.1016/j.jtbi.2022.111326

Mendonça et al., 2022

Michael Blinov 2022-11-22T21:05:25+00:00 November 22nd, 2022|publication, publication-2022|

Asynchronous glutamate release is enhanced in low release efficacy synapses and dispersed across the active zone.
Mendonça PR, Tagliatti E, Langley H, Kotzadimitriou D, Zamora-Chimal CG, Timofeeva Y, Volynski KE.
Nature communications. 2022 Jun 17;13(1):1-7.
PUBMED:35715404
doi:10.1038/s41467-022-31070-4

Sinner and Townsend, 2022

Michael Blinov 2022-10-03T22:00:00+00:00 October 3rd, 2022|publication, publication-2022|

Purification and characterization of sequential cobalamin-dependent radical SAM methylases ThnK and TokK in carbapenem β-lactam antibiotic biosynthesis.
Sinner EK, Townsend CA.
Methods in Enzymology. 2022; 669:29–44
PUBMED:35644176
https://doi.org/10.1016/bs.mie.2021.09.014

VCell and COPASI are used to study antibiotic biosynthesis

Michael Blinov 2022-12-07T16:08:36+00:00 October 3rd, 2022|News|

2022-09-28.VCell and COPASI were used together to study the kinetic behavior of antibiotic biosynthesis. The paper describes the same model designed in both COPASI (for parameter estimations) and VCell (for simulation reaction curves). Find links to the paper on our published models page.

VCell tutorial at ICSB 2022 in Berlin

Michael Blinov 2022-09-13T02:31:35+00:00 September 13th, 2022|News|

2022-09-12. The VCell team will give a tutorial at the 21st International Conference on Systems Biology – the premier meeting on systems studies in biology, human evolution disease and planetary health. The meeting will take place in Berlin, Germany on October 8th-12th. The tutorial will be on October 9th at 12:30pm local time (https://www.icsb2022.berlin/satellite-events).

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