Computational investigation of the dynamic control of cAMP signaling by PDE4 isoform types.
Paes, D., Hermans, S., van den Hove, D., Vanmierlo, T., Prickaerts, J., & Carlier, A.
Biophys J. 2022 Jul 19;121(14):2693-2711.
PUBMED:35717559
doi: 10.1016/j.bpj.2022.06.019
VCell BioModels referenced in the publication
user: aureliecarlier
biomodel name: Carlier_cAMP_isoforms_v2
biomodel name: Carlier_cAMP_isoforms_cyclic_v2
2022-06-18. VCell collaborator Aurélie Carlier from Maastricht University published a manuscript on computational investigation of the dynamic control of cAMP signaling by PDE4 isoform types. The authors demonstrated that cAMP signaling is distinctly regulated by different PDE4 isoform types andthat this isoform-specificity should be considered in both computational and experimental follow-up studies to better define PDE4 enzymes as therapeutic targets in diseases in which cAMP signaling is aberrant.
Paes, D., Hermans, S., van den Hove, D., Vanmierlo, […]
2022-05-25. The 23rd Computational Cell Biology workshop took place at R. D. Berlin Center for Cell Analysis and Modeling (CCAM) on May 23-25th. For 3 days more than 40 online participants learnt how to use VCell, COPASI and SpringSalad software tools for modeling of cell biology systems. 16 participants participated in the “project track”, working individually with CCAM staff on developing their modeling projects.
2022-04-14. A new compartmental VCell Model was used to explore nutrients transporter network in plants. Find links to the paper and BioModel on our published models page.
2022-02-10. VCell was used to analyze structure of a B12-dependent radical SAM enzyme in carbapenem biosynthesis in a new Nature paper (available on our published models page).
Name: “Carlier_cAMP_isoforms_cyclic_v2”
Saved: May 21, 2021
vcell identifier: biomodel-206022012
Owned by: “aureliecarlier”
Name: “Carlier_cAMP_isoforms_v2”
Saved: Apr 26, 2021
vcell identifier: biomodel-205406319
Owned by: “aureliecarlier”
The Atypical Cobalamin-Dependent S-Adenosyl-l-Methionine Nonradical Methylase TsrM and Its Radical Counterparts.
Ulrich EC, Drennan CL
J Am Chem Soc. 2022 Apr 6;144(13):5673-5684
PUBMED:35344653
doi:10.1021/jacs.1c12064
A kinetic model of phospholipase C-γ1 linking structure-based insights to dynamics of enzyme autoinhibition and activation.
Nosbisch JL, Bear JE, Haugh JM.
J Biol Chem. 2022 May;298(5):101886.
PUBMED:35367415
doi: 10.1016/j.jbc.2022.101886
VCell BioModels referenced in publication
user: jnosbis
biomodel name: Nosbisch PLCgamma1 2021
biomodel name: Nosbisch PLCgamma1 + polarization 2021
Methylations in complex carbapenem biosynthesis are catalyzed by a single cobalamin-dependent radical S-adenosylmethionine enzyme.
Sinner EK, Lichstrahl MS, Li R, Marous DR, Townsend CA
Chem Commun (Camb). 2019 Dec 10;55(99):14934-14937.
PUBMED:31774078
doi:10.1039/c9cc07197k
