2023-02-16. VCell collaborator Padmini Rangamani from University of California San Diego published a manuscript where a computational model of a mechanisms underlying divergent relationships between Ca2+ and YAP/TAZ signallingin was designed in VCell. The created system of ODEs was exported into MatLab for further simulations and processing.The model predicts context-dependent Ca2+ transient, CaMKII bistable response and frequency-dependent activation of LATS1/2 upstream regulators as mechanisms governing the Ca2+ -YAP/TAZ relationship.
Khalilimeybodi, A., Fraley, S. I., & Rangamani, P. (2023).
Mechanisms underlying divergent relationships between Ca2+ and YAP/TAZ signalling.
J Physiol. 601(3):483-515.
https://pubmed.ncbi.nlm.nih.gov/36463416/
One can check and download the VCell BioModel.