2025-10-12. Douglas Lin & Michael Martin from University of Louisville created a multicellular simulator implementing the Gillespie algorithm and compatible with Virtual Cell-designed networks to investigate a role of intercellular interactions on single cell and population level responses
Front Mol Biosci, 13:12:1595363. doi: 10.3389/fmolb.2025.1595363. eCollection 2025
https://pubmed.ncbi.nlm.nih.gov/41158874/
2025-10-09. VCell was presented at the International Conference on Systems Biology ICSB 2025 in Dublin, Ireland. A poster was presented by Michael Blinov describing the recent advances in VCell.
2025-09-20. VCell was used for teaching a short course on Systems Biology at Vytautas Magnus University – a leading public university in Lithuania. Michael Blinov was invited to give an intense 2 weeks course of 10 three-hour lectures every day. Many lectures featured Virtual VCell.
Resistance and germination of spores of Bacillus species lacking members of a spore integral inner membrane protein family and locations of these proteins in spores.
Khan, S., Wicander, J., Korza, G., Caldbeck, R., Cowan, A. E., Christie, G., & Setlow, P.
Journal of Bacteriology, 2025 Sept 207(10), e00217-25.
PUBMED: 40938645
https://doi.org/10.1128/jb.00217-25
Dynamics of homeostats: the basis of electrical, chemical, hydraulic, pH and calcium signaling in plants.
Contador-Álvarez, L., Rojas-Rocco, T., Rodríguez-Gómez, T., Rubio-Meléndez, M. E., Riedelsberger, J., Michard, E., & Dreyer, I.
Quantitative Plant Biology, 2025 Mar 21:6, e8.
doi.org:10.1017/qpb.2025.6
2025-03-18. Network-free simulations in VCell were used by U Toronto team led by Jonathan Ditlev to investigate how protein interactions, calcium, phosphorylation, and cholesterol modulate CFTR cluster formation on membranes. PNAS. 2025 Mar 18;122(11):e2424470122.
https://pubmed.ncbi.nlm.nih.gov/40063811/
Protein interactions, calcium, phosphorylation, and cholesterol modulate CFTR cluster formation on membranes
Wan Y, Hudson R, Smith J, Forman-Kay JD, Ditlev JA. Proceedings of the National Academy of Sciences. 2025 Mar 18;122(11):e2424470122.
PUBMED:40063811
https://doi.org/10.1073/pnas.2424470122
2025-03-09. Alberto Millan from Kite Corp and Lewis Lanier from UCSF published a study on ITAM-mediated human Natural killer cells signaling. VCell was used to create a rule-based model in .bngl (BioNetGen) format.
Millan, A. J., Allain, V., Nayak, I., Libang, J. B., Quijada-Madrid, L. M., Arakawa-Hoyt, J. S., … & Lanier, L. L. (2025). SYK negatively regulates ITAM-mediated human NK cell signaling and CD19-CAR NK cell efficacy. The Journal of Immunology, vkaf012
https://pubmed.ncbi.nlm.nih.gov/40073103/
SYK negatively regulates ITAM-mediated human NK cell signaling and CD19-CAR NK cell efficacy.
Millan, A. J., Allain, V., Nayak, I., Libang, J. B., Quijada-Madrid, L. M., Arakawa-Hoyt, J. S., … & Lanier, L. L.
The Journal of Immunology, 2025 March 21, vkaf012.
PUBMED: 40073103
doi.org:10.1093/jimmun/vkaf012
2025-02-28. The 26th Computational Cell Biology workshop took place ONLINE for the 5 days, February 24-28th. Cell biologists and biophysicists leaned how to use VCell (https://vcell.org/) and SpringSalad (https://vcell.org/ssalad) software to develop spatial and non-spatial models using deterministic, stochastic, agent- and rule-based approaches.
