2020-9-3. A new VCell model created incollaboration between the McCulloch and Zhang labs helped to demonstrate that a second phase of RhoA activation is required to maintain RhoA-mediated transcription after receptor signalling ends. Find links to the model and paper by Zhang et al. on our published models page.
Cell shape regulates subcellular organelle location to control early Ca2+ signal dynamics in vascular smooth muscle cells.
Calizo, R.C.; Bell, M.K.; Ron, A.; Hu, M.; Bhattacharya, S.; Wong, N.J.; Janssen, W.G.M.; Perumal, G.; Pederson, P.; Scarlata, S.; Hone, J.; Azeloglu, E.U.; Rangamani, P.; Iyengar, R.
Sci Rep. 2020 10:17866.
2020-10-20. A new publication from the Rangamani and Iyengar labs using VCell modeling to explore how cell shape affects calcium dynamics in vascular smooth muscle cells. Visit our published models page for links to the paper.
Activation of RhoA Allows for Persistent RhoA Signaling.
EZhang, J. Z.; Nguyen, A. H.; Miyamoto, S.; Heller Brown, J.; McCulloch, A. D.; Zhang, J.
PLoS Biol 2020, 18 (9), e3000866.
VCell BioModels referenced in publication:
user: jzz002, model name: KHistamtine-RhoA- Model_Final3
2020-08-05. The 2020 Computational Cell Biology Workshop was held as an online event Aug 3-5. Find videos of the key presentations here. Over 70 individuals participated overall; 16 individuals created models with VCell, COPASI and SpringSaLaD with help from CCAM team members in breakout rooms. A screen shot of one the opening day presentations serves in place of our traditional group photo this year.
2020-07-10. A new publication analyzes fluorescence photobleaching experiments using VCell numerical simulations to explore mechanisms of for differentiating somatodendritic and axonal compartments. Visit our published models page for links to the paper.