Name: “Brown et al 2011 Purkinje 3D Spine – Spinocerebellar Ataxia study”
Saved: Sat, 12 Mar 2011  12:56:21 GMT
vcell identifier: biomodel-55178308
Owned by: “Brown”

download model (.vcml)

Compartments, Species, Reactions
  • Compartment "spine".   (type: Volume)
    • Species "spinederriere"
    • Species "PA_spine"
    • Species "PABCa_spine"
    • Species "Mg_spine"
    • Species "r_spine"
    • Species "CGB_spine"
    • Species "CG_spine"
    • Species "D28kB_spine"
    • Species "D28k_spine"
    • Species "K_spine"
    • Species "D28k_high_spine"
    • Species "PABMg_spine"
    • Species "D28kB_high_spine"
    • Species "Edge"
    • Species "Na_spine"
    • Species "Ca_spine"
    • Species "ion_spine"
    • Species "IP3_spine"
    • Species "r_neck"
    • Species "l_neck"
    • Reaction "PABMg_diffusionThroughSpineNeck"   (PABMg_spine → ∅)
    • Reaction "D28k_high_diffusionThroughSpineNeck"   (D28k_high_spine → ∅)
    • Reaction "PA_Ca"   (Ca_spine + PA_spine → PABCa_spine)
    • Reaction "PABCa_diffusionThroughSpineNeck"   (PABCa_spine → ∅)
    • Reaction "D28k_diffusionThroughSpineNeck"   (D28k_spine → ∅)
    • Reaction "CGB_diffusionThroughSpineNeck"   (CGB_spine → ∅)
    • Reaction "PA_diffusionThroughSpineNeck"   (PA_spine → ∅)
    • Reaction "Ca_diffusionThroughSpineNeck"   (Ca_spine → ∅)
    • Reaction "PA_Mg"   (Mg_spine + PA_spine → PABMg_spine)
    • Reaction "IP3_degradation"   (IP3_spine → ∅)
    • Reaction "D28kB_high_diffusionThroughSpineNeck"   (D28kB_high_spine → ∅)
    • Reaction "CaD28k_med"   (D28k_spine + Ca_spine → D28kB_spine)
    • Reaction "CD28k_high"   (D28k_high_spine + Ca_spine → D28kB_high_spine)
    • Reaction "pulses for IP3 production"   (∅ → IP3_spine)
    • Reaction "IP3_diffusionThroughSpineNeck"   (IP3_spine → ∅)
    • Reaction "D28kB_diffusionThroughSpineNeck"   (D28kB_spine → ∅)
    • Reaction "CG_diffusionThroughSpineNeck"   (CG_spine → ∅)
    • Reaction "CGbinding"   (Ca_spine + CG_spine → CGB_spine)
  • Compartment "NondistributedER".   (type: Volume)
    • Species "Ca_NondistributedER"
  • Compartment "Extracellular".   (type: Volume)
    • Species "K_Extracellular"
    • Species "Ca_Extracellular"
    • Species "Na_Extracellular"
    • Species "ion_Extracellular"
  • Compartment "ER_spine".   (type: Volume)
    • Species "Ca_ER_spine"
  • Compartment "SM".   (type: Membrane)
    • Species "hKD_SM"
    • Species "mKM_SM"
    • Species "hKA_SM"
    • Species "mK23_SM"
    • Species "mKhh_SM"
    • Species "zKC3_SM"
    • Species "mCaE_SM"
    • Species "hCaE_SM"
    • Species "mKD_SM"
    • Species "mCaT_SM"
    • Species "mCaP2_SM"
    • Species "hCaT_SM"
    • Species "zK23_SM"
    • Species "PIP2Sink_SM"
    • Species "CentralPSD"
    • Species "LateralPSD"
    • Species "PIP2_SM"
    • Species "DAG_SM"
    • Species "PLC_act_SM"
    • Species "PLC_SM"
    • Species "Edge_SM"
    • Species "mKC3_SM"
    • Species "PIP2_bound_SM"
    • Species "mKA_SM"
    • Reaction "PLCact"   (PLC_SM → PLC_act_SM)
    • Reaction "CaEGate_m_spine"   (∅ → mCaE_SM)
    • Reaction "KDGate_m_spine"   (∅ → mKD_SM)
    • Reaction "CaTGate_h_spine"   (∅ → hCaT_SM)
    • Reaction "KMGate_m_spine"   (∅ → mKM_SM)
    • Reaction "K23Gate_m_spine"   (∅ → mK23_SM)
    • Reaction "PIP2_diffusionthroughspineneck"   (PIP2_SM → ∅)
    • Reaction "DAG_diffusionthroughspineneck"   (DAG_SM → ∅)
    • Reaction "CaP2Gate_m_spine"   (∅ → mCaP2_SM)
    • Reaction "KAGate_m_spine"   (∅ → mKA_SM)
    • Reaction "PIP2Binding"   (PIP2_SM + PIP2Sink_SM → PIP2_bound_SM)
    • Reaction "PIP2_hyd1"   (PIP2_bound_SM → DAG_SM + IP3_spine + PIP2Sink_SM)
    • Reaction "KAGate_h_spine"   (∅ → hKA_SM)
    • Reaction "KDGate_h_spine"   (∅ → hKD_SM)
    • Reaction "K23Gate_z_spine"   (∅ → zK23_SM)
    • Reaction "KhhGate_m_spine"   (∅ → mKhh_SM)
    • Reaction "PIP2_hyd"   (PIP2_SM → DAG_SM + IP3_spine)
    • Reaction "CaEGate_h_spine"   (∅ → hCaE_SM)
    • Reaction "CaTGate_m_spine"   (∅ → mCaT_SM)
    • Reaction "KC3Gate_z_spine"   (∅ → zKC3_SM)
    • Reaction "KC3Gate_m_spine"   (∅ → mKC3_SM)
    • Reaction "CaP2_spine"   (Ca_Extracellular → Ca_spine)
    • Reaction "KD_spine"   (K_Extracellular → K_spine)
    • Reaction "KM_spine"   (K_Extracellular → K_spine)
    • Reaction "CaT_spine"   (Ca_Extracellular → Ca_spine)
    • Reaction "K23_spine"   (K_Extracellular → K_spine)
    • Reaction "CaE_spine"   (Ca_Extracellular → Ca_spine)
    • Reaction "CF-induced Calcium Influx"   (Ca_Extracellular → Ca_spine)
    • Reaction "Leak_spine"   (ion_Extracellular → ion_spine)
    • Reaction "KA_spine"   (K_Extracellular → K_spine)
    • Reaction "Khh_spine"   (K_Extracellular → K_spine)
    • Reaction "drive_pump_spine"   (Ca_Extracellular → Ca_spine)
    • Reaction "drive_channel_spine"   (Ca_Extracellular → Ca_spine)
    • Reaction "KC3_spine"   (K_Extracellular → K_spine)
    • Reaction "Na-Ca Exchanger_nacaexch.mod"   (Ca_Extracellular → Ca_spine)
  • Compartment "ER_SM".   (type: Membrane)
    • Species "ERDensity_ER_SM"
    • Species "DistributedER"
    • Species "h_ER_SM"
    • Reaction "reaction0"   (h_ER_SM → ∅)
    • Reaction "IP3R_flux"   (Ca_spine → Ca_ER_spine)
    • Reaction "ER_leak_flux"   (Ca_spine → Ca_ER_spine)
    • Reaction "SERCA_flux"   (Ca_spine → Ca_ER_spine)
  • Compartment "NondistributedERM".   (type: Membrane)
    • Species "h_NondistributedERM"
    • Reaction "reaction1"   (h_NondistributedERM → ∅)
    • Reaction "JunctionalIP3R_flux"   (Ca_spine → Ca_NondistributedER)
    • Reaction "JunctionalSERCA_flux"   (Ca_spine → Ca_NondistributedER)
    • Reaction "JunctionalER_leak_flux"   (Ca_spine → Ca_NondistributedER)
2018-07-12T19:23:19+00:00 February 16th, 2018|biomodel|