Name: “EGF ras Sep 2012”
Saved: Thu, 18 Jul 2013  1:16:20 GMT
vcell identifier: biomodel-83446023
Owned by: “prangamani”

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Compartments, Species, Reactions
  • Compartment "extra".   (type: Volume)
    • Species "EGF_extra"
  • Compartment "nucleus".   (type: Volume)
    • Species "MAPK_active_N_nucleus"
  • Compartment "cyto".   (type: Volume)
    • Species "Raf_active_cyto"
    • Species "ATP"
    • Species "GAP"
    • Species "MEK_cyto"
    • Species "MAPK_active_cyto"
    • Species "Ras_GAP_cyto"
    • Species "MEK_active_cyto"
    • Species "MAPK_cyto"
    • Species "Sos_cyto"
    • Species "SHC_p_cyto"
    • Species "SHC_cyto"
    • Species "Raf_cyto"
    • Species "Grb2_cyto"
    • Species "PP2A_cyto"
    • Species "PP2A_inactive"
    • Reaction "SHC dephosphorylation"   (SHC_p_cyto → SHC_cyto)
    • Reaction "MEk activation"   (MEK_cyto → MEK_active_cyto)
    • Reaction "MAPK inactivation"   (MAPK_active_cyto → MAPK_cyto)
    • Reaction "MAPK activation"   (MAPK_cyto → MAPK_active_cyto)
    • Reaction "r0"   (PP2A_inactive → PP2A_cyto)
    • Reaction "Raf inactivation"   (Raf_active_cyto → Raf_cyto)
    • Reaction "MEK inactivation"   (MEK_active_cyto → MEK_cyto)
  • Compartment "cyto_mem".   (type: Membrane)
    • Species "EGFR_active"
    • Species "EGFR_GAP"
    • Species "EGFR_cyto_mem"
    • Species "EGFR_dimer"
    • Species "Ras_GDP_cyto_mem"
    • Species "Ras_GTP_cyto_mem"
    • Species "EGFR_GAP_GRb2_Sos"
    • Species "EGFR_Sos_Grb2_Shc_cyto_mem"
    • Species "EGFR_GAP_Grb2"
    • Reaction "receptor ligand binding"   (EGFR_cyto_mem + EGF_extra → EGFR_active)
    • Reaction "Ras activation by Sos"   (Ras_GDP_cyto_mem → Ras_GTP_cyto_mem)
    • Reaction "Ras GAP"   (Ras_GTP_cyto_mem → Ras_GDP_cyto_mem)
    • Reaction "Raf activation"   (Raf_cyto → Raf_active_cyto)
    • Reaction "Sos binding"   (EGFR_GAP_Grb2 + Sos_cyto → EGFR_GAP_GRb2_Sos)
    • Reaction "Shc phosphorylation"   (SHC_cyto → SHC_p_cyto)
    • Reaction "GAP binding"   (GAP + EGFR_dimer → EGFR_GAP)
    • Reaction "Shc binding EGFR"   (SHC_p_cyto + EGFR_GAP_GRb2_Sos → EGFR_Sos_Grb2_Shc_cyto_mem)
    • Reaction "dimerization"   (2 EGFR_active → EGFR_dimer)
    • Reaction "GRb2 binding"   (EGFR_GAP + Grb2_cyto → EGFR_GAP_Grb2)
  • Compartment "nuclear Membrane".   (type: Membrane)
    • Reaction "nuclear transport"   (MAPK_active_cyto → MAPK_active_N_nucleus)
2018-07-12T19:23:21+00:00 February 16th, 2018|biomodel|