Name: “Ca_Release_Coupled_MLC”
Saved: Fri, 03 Sep 2004  1:15:02 GMT
vcell identifier: biomodel-9254662
Owned by: “tjlukas”

download model (.vcml)

Compartments, Species, Reactions
  • Compartment "ER".   (type: Volume)
    • Species "Ca_ER"
  • Compartment "Nucleus".   (type: Volume)
    • Species "Ca_N"
    • Species "Fura2B_N"
    • Species "Buffer_N"
    • Species "IP3_N"
    • Species "Fura2_N"
    • Species "BufferB_N"
  • Compartment "cytosol".   (type: Volume)
    • Species "PKC_cytosol"
    • Species "MLC_cytosol"
    • Species "PKC_act_cytosol"
    • Species "DAG_cytosol"
    • Species "MLCP_cytosol"
    • Species "CaM_cytosol"
    • Species "cGKinase_cytosol"
    • Species "Ca_CaM_cytosol"
    • Species "MLCK_cytosol"
    • Species "Ca_CaM_MLCK_cytosol"
    • Species "CaM_MLCK_cytosol"
    • Species "Fura2B_cytosol"
    • Species "cGMP_cytosol"
    • Species "cGKinase_A_cytosol"
    • Species "Ca2_CaM_cytosol"
    • Species "Ca_dep_CaM_binding_cytosol"
    • Species "BufferB_cytosol"
    • Species "MLCP_P_cytosol"
    • Species "Ca_cytosol"
    • Species "CaM_bind_complex_cytosol"
    • Species "Fura2_cytosol"
    • Species "CaM_bind_cytosol"
    • Species "CPI_17_cytosol"
    • Species "CPI_17_P_cytosol"
    • Species "MLCP_CPI17P_cytosol"
    • Species "MLCK_P_cytosol"
    • Species "MLC_P_cytosol"
    • Species "IP3_cytosol"
    • Species "Buffer_cytosol"
    • Species "RhoA_cytosol"
    • Reaction "MLC_phosphatase"   (MLC_P_cytosol → MLC_cytosol)
    • Reaction "MLCK_CaM"   (CaM_cytosol + MLCK_cytosol → CaM_MLCK_cytosol)
    • Reaction "CPI17_dephospho"   (CPI_17_P_cytosol → CPI_17_cytosol)
    • Reaction "MLCP_CPIcomplex"   (MLCP_cytosol + CPI_17_P_cytosol → MLCP_CPI17P_cytosol)
    • Reaction "MLCKact"   (Ca_CaM_cytosol + MLCK_cytosol → Ca_CaM_MLCK_cytosol)
    • Reaction "Ca_dep_CaM"   (CaM_bind_cytosol + Ca_CaM_cytosol → Ca_dep_CaM_binding_cytosol)
    • Reaction "MLCP_CPI_17_dephos"   (MLCP_CPI17P_cytosol → CPI_17_cytosol + MLCP_cytosol)
    • Reaction "Ca_bind"   (CaM_cytosol + 2 Ca_cytosol → Ca_CaM_cytosol)
    • Reaction "Rho_deg"   (RhoA_cytosol → ∅)
    • Reaction "MLCP_reactive"   (MLCP_P_cytosol → MLCP_cytosol)
    • Reaction "IP3deg"   (IP3_cytosol → ∅)
    • Reaction "cGMP_activation"   (cGMP_cytosol + cGKinase_cytosol → cGKinase_A_cytosol)
    • Reaction "MLCK_CaM_Ca"   (2 Ca_cytosol + CaM_MLCK_cytosol → Ca_CaM_MLCK_cytosol)
    • Reaction "Fura2Bound"   (Fura2_cytosol + Ca_cytosol → Fura2B_cytosol)
    • Reaction "MLC_kinase"   (MLC_cytosol → MLC_P_cytosol)
    • Reaction "CaM_bind_disso"   (CaM_bind_complex_cytosol + 2 Ca_cytosol → Ca2_CaM_cytosol + CaM_bind_cytosol)
    • Reaction "CaM_binder"   (CaM_bind_cytosol + CaM_cytosol → CaM_bind_complex_cytosol)
    • Reaction "PKC_activate"   (PKC_cytosol + DAG_cytosol → PKC_act_cytosol)
    • Reaction "CPIactivation"   (CPI_17_cytosol → CPI_17_P_cytosol)
    • Reaction "Phospho_MLCP"   (MLC_P_cytosol → MLC_cytosol)
    • Reaction "MLCKPhospho"   (MLCK_cytosol → MLCK_P_cytosol)
    • Reaction "BufferBound"   (Buffer_cytosol + Ca_cytosol → BufferB_cytosol)
    • Reaction "DAG_deg"   (DAG_cytosol → ∅)
    • Reaction "ROK_activity"   (MLCP_cytosol → MLCP_P_cytosol)
    • Reaction "Ca2_4"   (2 Ca_cytosol + Ca2_CaM_cytosol → Ca_CaM_cytosol)
  • Compartment "extracellular".   (type: Volume)
    • Species "Ca_extracellula"
    • Species "Ligand_extracellular"
  • Compartment "ERM".   (type: Membrane)
    • Species "ERDensity"
    • Species "h_ERM"
    • Reaction "h_rxn"   (h_ERM → ∅)
    • Reaction "ER_leak_flux"   (Ca_cytosol → Ca_ER)
    • Reaction "SERCA_flux"   (Ca_cytosol → Ca_ER)
    • Reaction "IP3R_flux"   (Ca_cytosol → Ca_ER)
  • Compartment "NucM".   (type: Membrane)
    • Reaction "PCaNflux"   (Ca_cytosol → Ca_N)
    • Reaction "Fura2Nflux"   (Fura2_cytosol → Fura2_N)
    • Reaction "Fura2BNflux"   (Fura2B_cytosol → Fura2B_N)
    • Reaction "IP3Nflux"   (IP3_cytosol → IP3_N)
  • Compartment "PM".   (type: Membrane)
    • Species "L_Receptor_PM"
    • Species "PLC_Ca_PM"
    • Species "PIP_PM"
    • Species "Receptor_PM"
    • Species "PLC_PM"
    • Species "PLC_act_PM"
    • Species "DAG_PM"
    • Species "PIP2_PM"
    • Species "Ga_GTP_PM"
    • Species "Ga_GDP_PM"
    • Species "Receptor_Ga_GDP_PM"
    • Species "L_Receptor_P_GaGDP_PM"
    • Species "L_Receptor_GaGDP_PM"
    • Species "_2Dcorr_PM"
    • Species "L_ReceptorS_PM"
    • Species "Receptor2_PM"
    • Species "L_Receptor2_PM"
    • Species "L_Receptor_Ga_PM"
    • Reaction "Receptor_act"   (Receptor_PM + Ga_GDP_PM → Receptor_Ga_GDP_PM)
    • Reaction "PLC_act2"   (PLC_Ca_PM + Ga_GTP_PM → PLC_act_PM)
    • Reaction "Ga_GTPhydrol"   (Ga_GTP_PM → ∅)
    • Reaction "L_Receptor_phospho"   (L_Receptor_GaGDP_PM → L_Receptor_P_GaGDP_PM)
    • Reaction "IP3syn"   (PIP2_PM → IP3_cytosol + DAG_PM)
    • Reaction "Ga_Rho_exch"   (Ga_GTP_PM → RhoA_cytosol)
    • Reaction "Uncoupled_R_activation"   (Ga_GDP_PM + L_ReceptorS_PM → L_Receptor_GaGDP_PM)
    • Reaction "G_dissoc_2"   (L_Receptor_Ga_PM → L_Receptor2_PM + Ga_GTP_PM)
    • Reaction "DAG_xfer"   (DAG_PM → DAG_cytosol)
    • Reaction "PLC_CalB"   (Ca_cytosol + PLC_PM → PLC_Ca_PM)
    • Reaction "Lig_unact_recepB"   (Ligand_extracellular + Receptor_PM → L_ReceptorS_PM)
    • Reaction "J_PIP2syn"   (PIP_PM → PIP2_PM)
    • Reaction "PLC_activate"   (PLC_PM + Ga_GTP_PM → PLC_act_PM)
    • Reaction "GDPexch"   (L_Receptor_GaGDP_PM → Ga_GTP_PM + L_Receptor_PM)
    • Reaction "Ligand_binding"   (Receptor_Ga_GDP_PM + Ligand_extracellular → L_Receptor_GaGDP_PM)
    • Reaction "b1binding"   (Receptor2_PM + Ligand_extracellular → L_Receptor_Ga_PM)
    • Reaction "PLC_GAP"   (PLC_act_PM → PLC_PM)
    • Reaction "IP3genbasal"   (PIP2_PM → IP3_cytosol + DAG_PM)
    • Reaction "Ligand_recept_deg"   (L_Receptor_PM → ∅)
    • Reaction "Ca Channel"   (Ca_extracellula → Ca_cytosol)
    • Reaction "CaPumpFlux"   (Ca_extracellula → Ca_cytosol)
2018-07-12T19:23:13+00:00 February 16th, 2018|biomodel|