Name: “KeumKruseKimHilleSuh_2016”
Saved: Thu, 28 Jan 2016  20:53:00 GMT
vcell identifier: biomodel-98174143
Owned by: “hillelab”

download model (.vcml)

Compartments, Species, Reactions
  • Compartment "EX".   (type: Volume)
    • Species "IP3_pipette"
    • Species "oxoM_EX"
    • Species "OxoM_conc_EX"
    • Species "K_EX"
    • Reaction "Oxo_appl"   (OxoM_conc_EX → oxoM_EX)
  • Compartment "Ca_store".   (type: Volume)
    • Species "Ca_Ca_store"
  • Compartment "C".   (type: Volume)
    • Species "IP3_PH_YFP_C"
    • Species "C1_dom_C"
    • Species "K_C"
    • Species "Ca_C"
    • Species "IP3_LibraVIII_C"
    • Species "LibraVIII_C"
    • Species "PH_YFP_C"
    • Species "Ca_Fura4F_C"
    • Species "Fura4F_C"
    • Species "IP3_C"
    • Species "Palk_C1"
    • Species "Palk_C2"
    • Species "Palk_C3"
    • Species "Palk_O4"
    • Species "TAPP1_dom_C"
    • Species "PH_Btk_dom_C"
    • Species "P4M_dom_C"
    • Reaction "Cabind_Fura4F"   (Ca_C + Fura4F_C → Ca_Fura4F_C)
    • Reaction "IP3_LibraVIII"   (LibraVIII_C + IP3_C → IP3_LibraVIII_C)
    • Reaction "IP3deg_Palk"   (IP3_C → ∅)
    • Reaction "r12"   (Palk_C1 → Palk_C2)
    • Reaction "r23"   (Palk_C2 → Palk_C3)
    • Reaction "r24"   (Palk_C2 → Palk_O4)
    • Reaction "PH_YFP_IP3"   (IP3_C + PH_YFP_C → IP3_PH_YFP_C)
    • Reaction "IP3Pase_FDH"   (IP3_C → ∅)
  • Compartment "M".   (type: Membrane)
    • Species "PI4P_M"
    • Species "PH_YFP_PIP2_M"
    • Species "KCNQ_M"
    • Species "PI_M"
    • Species "RLG_GDP_M"
    • Species "RL_M"
    • Species "GaGTP_PLC_M"
    • Species "GaGTP_M"
    • Species "RLGbeta_M"
    • Species "Gbeta_M"
    • Species "RGbeta_M"
    • Species "R_M"
    • Species "boundPIP2_M"
    • Species "G_GDP_M"
    • Species "RG_GDP_M"
    • Species "Ga_GDP_M"
    • Species "DAG_M"
    • Species "PA_2AG_M"
    • Species "PLC_M"
    • Species "PIP2_M"
    • Species "C1_DAG_M"
    • Species "GaGDP_PLC_M"
    • Species "KCNQ_PIP2_M"
    • Species "PIP3"
    • Species "PI3_4_P2"
    • Species "TAPP1_PI34P2_M"
    • Species "PH_Btk_PIP3_M"
    • Species "P4M_PI4P_M"
    • Species "PI4P_VSPbound"
    • Reaction "PLC_on_PI4P"   (PI4P_M → DAG_M)
    • Reaction "NE_RG"   (RG_GDP_M → GaGTP_M + RGbeta_M)
    • Reaction "L1"   (oxoM_EX + R_M → RL_M)
    • Reaction "PIP5K_5Pase"   (PI4P_M → PIP2_M)
    • Reaction "NE_G"   (G_GDP_M → GaGTP_M + Gbeta_M)
    • Reaction "GTPase_Ga"   (GaGTP_M → Ga_GDP_M)
    • Reaction "PIP2_buffering"   (PIP2_M → boundPIP2_M)
    • Reaction "L2beta"   (oxoM_EX + RGbeta_M → RLGbeta_M)
    • Reaction "NE_RLG"   (RLG_GDP_M → RLGbeta_M + GaGTP_M)
    • Reaction "NE_GaP"   (GaGDP_PLC_M → GaGTP_PLC_M)
    • Reaction "PH_YFP_PIP2"   (PIP2_M + PH_YFP_C → PH_YFP_PIP2_M)
    • Reaction "VSP"   (PIP2_M → PI4P_M)
    • Reaction "G1beta"   (Gbeta_M + R_M → RGbeta_M)
    • Reaction "DAGPase"   (DAG_M → PA_2AG_M)
    • Reaction "PI4K_4Pase"   (PI_M → PI4P_M)
    • Reaction "G2beta"   (RL_M + Gbeta_M → RLGbeta_M)
    • Reaction "PLCdiss"   (GaGDP_PLC_M → Ga_GDP_M + PLC_M)
    • Reaction "L2"   (oxoM_EX + RG_GDP_M → RLG_GDP_M)
    • Reaction "PLCassoc"   (PLC_M + GaGTP_M → GaGTP_PLC_M)
    • Reaction "G1"   (G_GDP_M + R_M → RG_GDP_M)
    • Reaction "PIP2bindKCNQ"   (KCNQ_M + PIP2_M → KCNQ_PIP2_M)
    • Reaction "PIP2hydr"   (PIP2_M → DAG_M + IP3_C)
    • Reaction "IP3_dialysis"   (IP3_pipette → IP3_C)
    • Reaction "GTPase_GaP"   (GaGTP_PLC_M → GaGDP_PLC_M)
    • Reaction "G2"   (G_GDP_M + RL_M → RLG_GDP_M)
    • Reaction "reconstitution"   (Gbeta_M + Ga_GDP_M → G_GDP_M)
    • Reaction "C1bindDAG"   (DAG_M + C1_dom_C → C1_DAG_M)
    • Reaction "VSP_5P_PIP3"   (PIP3 → PI3_4_P2)
    • Reaction "PI3K_PTEN"   (PIP2_M → PIP3)
    • Reaction "TAPP1_binding"   (TAPP1_dom_C + PI3_4_P2 → TAPP1_PI34P2_M)
    • Reaction "PH_Btk_binding"   (PH_Btk_dom_C + PIP3 → PH_Btk_PIP3_M)
    • Reaction "PI3K_on_PIP4P"   (PI3_4_P2 → PI4P_M)
    • Reaction "P4M_PI4P_binding"   (P4M_dom_C + PI4P_M → P4M_PI4P_M)
    • Reaction "VSP_3P_PIP3"   (PIP3 → PIP2_M)
    • Reaction "PIPKIgamma_PIP"   (PI4P_M → PIP2_M)
    • Reaction "PIPKIgamma_PI34P2"   (PI3_4_P2 → PIP3)
    • Reaction "VSP_3P_PI34P2"   (PI3_4_P2 → PI4P_VSPbound)
    • Reaction "PI4P_VSPbound_release"   (PI4P_VSPbound → PI4P_M)
    • Reaction "KCNQ2/3"   (K_EX → K_C)
  • Compartment "ERM".   (type: Membrane)
    • Species "inactiveIP3R"
    • Species "noninactiveIP3R"
    • Reaction "h_reaction_IP3Rinactivation"   (noninactiveIP3R → inactiveIP3R)
    • Reaction "RyR_Palk"   (Ca_C → Ca_Ca_store)
    • Reaction "leak_Palk"   (Ca_C → Ca_Ca_store)
    • Reaction "SERCA_Palk"   (Ca_C → Ca_Ca_store)
    • Reaction "ER_leak_flux_FDH"   (Ca_C → Ca_Ca_store)
    • Reaction "IP3R_flux_FDH"   (Ca_C → Ca_Ca_store)
    • Reaction "SERCA_flux_FDH"   (Ca_C → Ca_Ca_store)
    • Reaction "IP3R_Palk"   (Ca_C → Ca_Ca_store)