biomodel-147699816

Name: “Surve_et_alRAF1”
Saved: Wed, 20 Apr 2005
vcell identifier: biomodel-147699816
Owned by: “pmyers1995”

download model (.vcml)

• Compartment "cytoplasm".   (type: Volume)
  • Species "sorafenib"
  • Species "Raf1"
  • Species "pRaf1"
  • Species "iRaf1"
  • Species "BRaf"
  • Species "MEK"
  • Species "pMEK"
  • Species "ERK"
  • Species "iBRaf"
  • Species "pERK"
  • Species "nfpRaf1"
  • Species "nfpBRaf"
  • Species "nfpiBRaf"
  • Species "nfpiRaf1"
  • Reaction "sorafenib_Raf1_bind_cyt"   (sorafenib + Raf1 → iRaf1)
  • Reaction "pRaf1_dephosph"   (pRaf1 → Raf1)
  • Reaction "sorafenib_BRaf_bind_cyt"   (sorafenib + BRaf → iBRaf)
  • Reaction "MEK_p"   (MEK → pMEK)
  • Reaction "MEK_dp"   (pMEK → MEK)
  • Reaction "ERK_p"   (ERK → pERK)
  • Reaction "ERK_dp"   (pERK → ERK)
  • Reaction "nfpRaf1_dp"   (nfpRaf1 → Raf1)
  • Reaction "nfpBRaf_dp"   (nfpBRaf → BRaf)
  • Reaction "nfpiRaf_dp"   (nfpiRaf1 → iRaf1)
  • Reaction "nfpiBRaf_dp"   (nfpiBRaf → iBRaf)
• Compartment "pm".   (type: Membrane)
  • Species "GTP_Ras"
  • Species "Ras_Raf1"
  • Species "Ras_iRaf1"
  • Species "Ras_pRaf1_Raf1_tetramer"
  • Species "Ras_BRaf"
  • Species "Ras_pRaf1"
  • Species "Ras_BRaf_Raf1_tetramer"
  • Species "Ras_iRaf1_tetramer"
  • Species "Ras_Braf_iRaf1_tetramer"
  • Species "Ras_pRaf1_tetramer"
  • Species "Ras_BRaf_pRaf1_tetramer"
  • Species "Ras_Raf1_iBRaf_tetramer"
  • Species "Ras_pRaf1_iBRaf_tetramer"
  • Species "iBRaf_dimer"
  • Species "BRaf_dimer"
  • Species "Ras_iBRaf"
  • Species "Ras_nfpRaf1"
  • Species "Ras_nfpBRaf"
  • Species "BRaf_iBRaf_dimer"
  • Species "Ras_nfpiBRaf"
  • Species "Ras_nfpiRaf1"
  • Species "Ras_iRaf1_iBRaf1_tetramer"
  • Reaction "Ras_Raf1_bind"   (Raf1 + GTP_Ras → Ras_Raf1)
  • Reaction "BRaf_Raf1_bind"   (Ras_BRaf + Ras_Raf1 → Ras_BRaf_Raf1_tetramer)
  • Reaction "BRaf_Raf1_phosph"   (Ras_BRaf_Raf1_tetramer → Ras_BRaf_pRaf1_tetramer)
  • Reaction "Ras_pRaf1_unbind"   (Ras_pRaf1 → pRaf1 + GTP_Ras)
  • Reaction "Ras_BRaf_bind"   (BRaf + GTP_Ras → Ras_BRaf)
  • Reaction "pRaf1_Raf1_bind"   (Ras_pRaf1 + Ras_Raf1 → Ras_pRaf1_Raf1_tetramer)
  • Reaction "pRaf1_Raf1_phosph"   (Ras_pRaf1_Raf1_tetramer → Ras_pRaf1_tetramer)
  • Reaction "Ras_iRaf1_bind"   (iRaf1 + GTP_Ras → Ras_iRaf1)
  • Reaction "iRaf1_iRaf1_bind"   (2 Ras_iRaf1 → Ras_iRaf1_tetramer)
  • Reaction "BRaf_iRaf1_bind"   (Ras_BRaf + Ras_iRaf1 → Ras_Braf_iRaf1_tetramer)
  • Reaction "pRaf1_pRaf1_unbind"   (Ras_pRaf1_tetramer → 2 Ras_pRaf1)
  • Reaction "BRaf_pRaf1_unbind"   (Ras_BRaf_pRaf1_tetramer → Ras_BRaf + Ras_pRaf1)
  • Reaction "Ras_iBRaf_b"   (iBRaf → Ras_iBRaf)
  • Reaction "iBRaf_dim"   (Ras_iBRaf → iBRaf_dimer)
  • Reaction "iBRaf_Raf1_bind"   (Ras_Raf1 + Ras_iBRaf → Ras_Raf1_iBRaf_tetramer)
  • Reaction "Raf1_iBRaf_p"   (Ras_Raf1_iBRaf_tetramer → Ras_pRaf1_iBRaf_tetramer)
  • Reaction "pRaf1_iBRaf_ub"   (Ras_pRaf1_iBRaf_tetramer → Ras_iBRaf + Ras_pRaf1)
  • Reaction "BRaf_dim"   (Ras_BRaf → BRaf_dimer)
  • Reaction "Ras_pRaf1_dp"   (Ras_pRaf1 → Ras_Raf1)
  • Reaction "Ras_Raf1_nfp"   (Ras_Raf1 → Ras_nfpRaf1)
  • Reaction "nfpRaf1_ub"   (Ras_nfpRaf1 → GTP_Ras + nfpRaf1)
  • Reaction "BRaf_nfp"   (Ras_BRaf → Ras_nfpBRaf)
  • Reaction "nfpBRaf_ub"   (Ras_nfpBRaf → GTP_Ras + nfpBRaf)
  • Reaction "BRaf_iBRaf_dim"   (Ras_iBRaf + Ras_BRaf → BRaf_iBRaf_dimer)
  • Reaction "Ras_iRaf_nfp"   (Ras_iRaf1 → Ras_nfpiRaf1)
  • Reaction "nfpiRaf1_ub"   (Ras_nfpiRaf1 → nfpiRaf1 + GTP_Ras)
  • Reaction "Ras_iBRaf_nfp"   (Ras_iBRaf → Ras_nfpiBRaf)
  • Reaction "nfpiBRaf_ub"   (Ras_nfpiBRaf → nfpiBRaf + GTP_Ras)
  • Reaction "iRaf_iBRaf_dim"   (Ras_iRaf1 + Ras_iBRaf → Ras_iRaf1_iBRaf1_tetramer)