Name: “A predictive computational model reveals that GIV/Girdin serves as a tunable valve for EGFR-stimulated Cyclic AMP Signals”
Saved: Apr 30, 2019
vcell identifier: biomodel-156134818
Owned by: “mgetz”
- Compartment "Endosome". (type: Volume)
- Species "EGFi"
- Reaction "EGF_deg" (EGFi → ∅)
- Compartment "Cyto". (type: Volume)
- Species "PLCg"
- Species "IP3"
- Species "inositol"
- Species "PKC"
- Species "ATP"
- Species "cAMP"
- Species "PKA"
- Species "PDE"
- Species "R2C2"
- Species "AMP"
- Species "PDEp"
- Species "PP_PDE"
- Species "PLCg_active"
- Species "GIV"
- Species "GIV_GEF"
- Species "GIV_GDI"
- Species "Cdk5"
- Species "R2"
- Species "R2u"
- Species "R2uu"
- Species "PKA_inact"
- Species "GIV89p"
- Reaction "Degradation_GDI" (GIV_GDI → GIV)
- Reaction "Degradation_GEF" (GIV_GEF → GIV)
- Reaction "IP3_degradation" (IP3 → inositol)
- Reaction "PDE_phos" (PDE → PDEp)
- Reaction "PKA_inactivation" (PKA → PKA_inact)
- Reaction "PKA_reformation" (R2uu + 2 PKA → R2C2)
- Reaction "PLC_deactivation" (PLCg_active → PLCg)
- Reaction "R2uUnbind" (R2u → R2uu + 2 cAMP)
- Reaction "R2Unbind" (R2 → R2u + 2 cAMP)
- Reaction "cAMP_Activation" (R2C2 + 4 cAMP → R2 + 2 PKA)
- Reaction "cAMP_to_AMP" (cAMP → AMP)
- Reaction "cAMP_to_AMP_PDEp" (cAMP → AMP)
- Reaction "dephos_of_PDEp" (PDEp → PDE)
- Reaction "basalGIVGDI" (GIV + Gs_GDP_i → Gs_GDI_b)
- Reaction "_89pDEG" (GIV89p → GIV)
- Compartment "ECM". (type: Volume)
- Species "EGF"
- Compartment "intmem". (type: Membrane)
- Species "AC_act"
- Species "Gs_GTP_i"
- Species "Gs_GDP_i"
- Species "Gs_GDI_i"
- Species "EGF_EGFR_i_act"
- Species "AC_i"
- Species "bg_i"
- Species "EGFRi"
- Species "EGF_EGFRi"
- Species "EGF_EGFR_2i"
- Species "Gs_protein_i"
- Species "Gs_GDI_b"
- Species "I"
- Reaction "AC_activation" (AC_i + Gs_GTP_i → AC_act)
- Reaction "EGFR_deg" (EGFRi → ∅)
- Reaction "EGFR_to_PM" (EGFRi → EGFR)
- Reaction "GDI_function" (GIV_GDI + Gs_GDP_i → Gs_GDI_i)
- Reaction "Gs_GDI_accel_deg" (EGF_EGFR_i_act → ∅)
- Reaction "Gs_activation" (Gs_protein_i → bg_i + Gs_GTP_i)
- Reaction "Gs_hydrolysis" (Gs_GTP_i → Gs_GDP_i)
- Reaction "InactivAC" (AC_act → AC_i + Gs_GDP_i)
- Reaction "cAMP_basal_production_internal" (ATP → cAMP)
- Reaction "internal_trimerize" (bg_i + Gs_GDP_i → Gs_protein_i)
- Reaction "production_cAMP_internal" (ATP → cAMP)
- Reaction "v10" (EGFi + EGFRi → EGF_EGFRi)
- Reaction "v11" (2 EGF_EGFRi → EGF_EGFR_2i)
- Reaction "v12" (EGF_EGFR_2i → EGF_EGFR_i_act)
- Reaction "Gs_GDI_accel_deg_copy" (Gs_GDI_i → ∅)
- Reaction "Gs_GDI_accel_deg_copy2" (Gs_GDP_i → ∅)
- Reaction "Gs_GDI_accel_deg_copy3" (Gs_GTP_i → ∅)
- Reaction "Gs_GDI_accel_deg_copy4" (AC_act → ∅)
- Reaction "Gs_GDI_accel_deg_copy5" (EGF_EGFRi → ∅)
- Reaction "Gs_GDI_accel_deg_copy6" (Gs_GDI_b → ∅)
- Reaction "Intfun" (∅ → I)
- Compartment "PM". (type: Membrane)
- Species "EGFR"
- Species "p35"
- Species "p35_act"
- Species "Gi_GTP"
- Species "Gi_GDP"
- Species "EGF_EGFR"
- Species "PKC_act"
- Species "AC"
- Species "PIP2"
- Species "EGF_EGFR_2_act"
- Species "EGF_EGFR_2"
- Species "DAG"
- Species "GEF_EGFR"
- Species "GEF_Gi_EGFR"
- Species "AC_inact"
- Species "Gs_protein"
- Species "Cdk5_p35_act"
- Reaction "AC_inactivation" (AC + Gi_GTP → AC_inact)
- Reaction "AC_internalization" (AC → AC_i)
- Reaction "AC_unbinding" (AC_inact → AC + Gi_GDP)
- Reaction "Cdk5_activation" (Cdk5 + p35_act → Cdk5_p35_act)
- Reaction "DAG_decactivation" (DAG → ∅)
- Reaction "DAG_deactivation_while_bound" (PKC_act → PKC)
- Reaction "Dimerize" (2 EGF_EGFR → EGF_EGFR_2)
- Reaction "Dimerized_receptor_activation" (EGF_EGFR_2 → EGF_EGFR_2_act)
- Reaction "EGFR_GEF_to_GDI" (GEF_EGFR → GIV_GDI + EGF_EGFR_2_act)
- Reaction "GEF_EGFR_binding" (GIV_GEF + EGF_EGFR_2_act → GEF_EGFR)
- Reaction "GEF_Gi_Binding" (GEF_EGFR + Gi_GDP → GEF_Gi_EGFR)
- Reaction "GEF_activation" (GIV → GIV_GEF)
- Reaction "GEF_to_GDI" (GIV_GEF → GIV_GDI)
- Reaction "Gi_activation" (GEF_Gi_EGFR → GEF_EGFR + Gi_GTP)
- Reaction "Gi_hydrolysis" (Gi_GTP → Gi_GDP)
- Reaction "Gs_internalization" (Gs_protein → Gs_protein_i)
- Reaction "PIP2_to_DAG" (PIP2 → DAG + IP3)
- Reaction "PKC_activation" (PKC + DAG → PKC_act)
- Reaction "PLC_GEF_enhanced" (PLCg → PLCg_active)
- Reaction "PLC_activation_basal" (PLCg → PLCg_active)
- Reaction "cAMP_basal" (ATP → cAMP)
- Reaction "internal_transport" (EGF_EGFR_2_act → EGF_EGFR_i_act)
- Reaction "p35_activation" (p35 → p35_act)
- Reaction "p35_inactivation" (p35_act → p35)
- Reaction "receptor_ligand_binding" (EGF + EGFR → EGF_EGFR)