biomodel-83446023

Name: “EGF ras Sep 2012”
Saved: Thu, 18 Jul 2013  1:16:20 GMT
vcell identifier: biomodel-83446023
Owned by: “prangamani”

download model (.vcml)

• Compartment "extra".   (type: Volume)
  • Species "EGF_extra"
• Compartment "nucleus".   (type: Volume)
  • Species "MAPK_active_N_nucleus"
• Compartment "cyto".   (type: Volume)
  • Species "Raf_active_cyto"
  • Species "ATP"
  • Species "GAP"
  • Species "MEK_cyto"
  • Species "MAPK_active_cyto"
  • Species "Ras_GAP_cyto"
  • Species "MEK_active_cyto"
  • Species "MAPK_cyto"
  • Species "Sos_cyto"
  • Species "SHC_p_cyto"
  • Species "SHC_cyto"
  • Species "Raf_cyto"
  • Species "Grb2_cyto"
  • Species "PP2A_cyto"
  • Species "PP2A_inactive"
  • Reaction "SHC dephosphorylation"   (SHC_p_cyto → SHC_cyto)
  • Reaction "MEk activation"   (MEK_cyto → MEK_active_cyto)
  • Reaction "MAPK inactivation"   (MAPK_active_cyto → MAPK_cyto)
  • Reaction "MAPK activation"   (MAPK_cyto → MAPK_active_cyto)
  • Reaction "r0"   (PP2A_inactive → PP2A_cyto)
  • Reaction "Raf inactivation"   (Raf_active_cyto → Raf_cyto)
  • Reaction "MEK inactivation"   (MEK_active_cyto → MEK_cyto)
• Compartment "cyto_mem".   (type: Membrane)
  • Species "EGFR_active"
  • Species "EGFR_GAP"
  • Species "EGFR_cyto_mem"
  • Species "EGFR_dimer"
  • Species "Ras_GDP_cyto_mem"
  • Species "Ras_GTP_cyto_mem"
  • Species "EGFR_GAP_GRb2_Sos"
  • Species "EGFR_Sos_Grb2_Shc_cyto_mem"
  • Species "EGFR_GAP_Grb2"
  • Reaction "receptor ligand binding"   (EGFR_cyto_mem + EGF_extra → EGFR_active)
  • Reaction "Ras activation by Sos"   (Ras_GDP_cyto_mem → Ras_GTP_cyto_mem)
  • Reaction "Ras GAP"   (Ras_GTP_cyto_mem → Ras_GDP_cyto_mem)
  • Reaction "Raf activation"   (Raf_cyto → Raf_active_cyto)
  • Reaction "Sos binding"   (EGFR_GAP_Grb2 + Sos_cyto → EGFR_GAP_GRb2_Sos)
  • Reaction "Shc phosphorylation"   (SHC_cyto → SHC_p_cyto)
  • Reaction "GAP binding"   (GAP + EGFR_dimer → EGFR_GAP)
  • Reaction "Shc binding EGFR"   (SHC_p_cyto + EGFR_GAP_GRb2_Sos → EGFR_Sos_Grb2_Shc_cyto_mem)
  • Reaction "dimerization"   (2 EGFR_active → EGFR_dimer)
  • Reaction "GRb2 binding"   (EGFR_GAP + Grb2_cyto → EGFR_GAP_Grb2)
• Compartment "nuclear Membrane".   (type: Membrane)
  • Reaction "nuclear transport"   (MAPK_active_cyto → MAPK_active_N_nucleus)