Name: “Song_PNAS_2013”
Saved: Mon, 23 Sep 2013 12:39:58 GMT
vcell identifier: biomodel-84275910
Owned by: “rsong”
- Compartment "IC". (type: Volume)
- Species "CaM_Ca4"
- Species "PDE2_IBMX"
- Species "Gap"
- Species "R2C2_cAMP3"
- Species "SoS_Pi_Grb2"
- Species "PDE4_ERK_PKA"
- Species "R2C2_cAMP"
- Species "PP1"
- Species "DARPP32_Pi_PP1"
- Species "I1_Pi_PP1"
- Species "PDE4_ERK"
- Species "AMPAR_Bulk"
- Species "IP3_degraded"
- Species "IP3_14"
- Species "PKC_active"
- Species "PP2A"
- Species "PP1_PDE"
- Species "cAMP"
- Species "U0126"
- Species "DARPP32"
- Species "Rolipram"
- Species "R2C_cAMP4"
- Species "PDE3_IBMX"
- Species "R2_cAMP4"
- Species "STEP_PKA"
- Species "BRaf_Pi"
- Species "PDE1_CaM_Ca4"
- Species "GluR1_845_818"
- Species "Raf"
- Species "IBMX"
- Species "PDEbg"
- Species "PKA_active"
- Species "PDE1_IBMX"
- Species "GluR1_degraded"
- Species "GluR1"
- Species "MEK_Ser"
- Species "ERK_Tyr"
- Species "IP3_5pase1"
- Species "PDE4_PKA"
- Species "MEK"
- Species "CaM"
- Species "Four1N"
- Species "PDE4_IBMX"
- Species "I1_Pi"
- Species "ERK"
- Species "PDE4_Rolipram"
- Species "PKA_Inhibitor"
- Species "CaMKII_286_CaM"
- Species "Ras_GDP"
- Species "MEK_inhibited"
- Species "R2C2_cAMP4"
- Species "Ras_Raf_active"
- Species "SoS_Grb2"
- Species "ATP"
- Species "GluR1_845"
- Species "IP3_5Pase2"
- Species "Shc"
- Species "Ras_GTP"
- Species "R2C2"
- Species "CaMKII"
- Species "BRaf"
- Species "R2C2_cAMP2"
- Species "PDE1"
- Species "CaM_Ca2"
- Species "PDE2"
- Species "BDNF_TrkB2_Pi"
- Species "ERK_active"
- Species "Shc_Pi"
- Species "IP3_145"
- Species "MEK_active"
- Species "AMP"
- Species "Grb2"
- Species "STEP"
- Species "PDE3"
- Species "Calcium"
- Species "CaMKII_CaM"
- Species "SoS"
- Species "PDE4"
- Species "CaMKII_286"
- Species "SoS_Pi"
- Species "PKA_inhibited"
- Species "CaM_Ca3"
- Species "I1"
- Species "DARPP32_Pi"
- Species "Shc_Pi_SoS_Grb2"
- Species "PP2A_DI"
- Reaction "091" (CaM_Ca3 + Calcium → CaM_Ca4)
- Reaction "r19" (PDE1 + IBMX → PDE1_IBMX)
- Reaction "r40" (IP3_145 → IP3_14)
- Reaction "057" (DARPP32_Pi → DARPP32)
- Reaction "087" (R2C_cAMP4 → PKA_active + R2_cAMP4)
- Reaction "r10" (Rolipram + PDE4_ERK_PKA → PDE4_Rolipram)
- Reaction "r21" (IBMX + PDE4 → PDE4_IBMX)
- Reaction "096" (CaMKII_286 → CaMKII)
- Reaction "056" (DARPP32 → DARPP32_Pi)
- Reaction "036" (ERK → ERK_Tyr)
- Reaction "r52" (cAMP → AMP)
- Reaction "078" (cAMP → AMP)
- Reaction "r38" (IP3_145 → IP3_degraded)
- Reaction "r12" (cAMP → AMP)
- Reaction "r6" (PDE3 + IBMX → PDE3_IBMX)
- Reaction "100" (AMPAR_Bulk → GluR1)
- Reaction "r11" (Rolipram + PDE4_PKA → PDE4_Rolipram)
- Reaction "r55" (PDE4_ERK_PKA → PDE4)
- Reaction "011" (Shc → Shc_Pi)
- Reaction "012" (SoS → SoS_Pi)
- Reaction "097" (CaMKII_286_CaM → CaMKII_CaM)
- Reaction "023" (Ras_GTP → Ras_GDP)
- Reaction "084" (R2C2_cAMP2 + cAMP → R2C2_cAMP3)
- Reaction "098" (PDE1 + CaM_Ca4 → PDE1_CaM_Ca4)
- Reaction "081" (cAMP → AMP)
- Reaction "077" (cAMP → AMP)
- Reaction "032" (MEK_Ser → MEK)
- Reaction "008" (SoS_Pi + Grb2 → SoS_Pi_Grb2)
- Reaction "006" (Shc_Pi → Shc)
- Reaction "046" (PDE4_PKA → PDE4)
- Reaction "060" (I1 → I1_Pi)
- Reaction "018" (Ras_GDP → Ras_GTP)
- Reaction "r48" (cAMP → AMP)
- Reaction "045" (PDE4 → PDE4_PKA)
- Reaction "009" (SoS_Pi → SoS)
- Reaction "r50" (cAMP → AMP)
- Reaction "r56" (GluR1_845_818 → GluR1_845)
- Reaction "007" (SoS_Grb2 + Shc_Pi → Shc_Pi_SoS_Grb2)
- Reaction "106" (GluR1 → GluR1_845)
- Reaction "088" (PKA_active + PKA_Inhibitor → PKA_inhibited)
- Reaction "r24" (PDE4_ERK + IBMX → PDE4_IBMX)
- Reaction "r22" (PDE4_PKA + IBMX → PDE4_IBMX)
- Reaction "010" (Grb2 + SoS → SoS_Grb2)
- Reaction "r18" (DARPP32_Pi + PP1 → DARPP32_Pi_PP1)
- Reaction "r49" (ERK_active → ERK_Tyr)
- Reaction "034" (MEK → MEK_Ser)
- Reaction "063" (BRaf_Pi → BRaf)
- Reaction "r47" (DARPP32_Pi_PP1 → PP1 + DARPP32)
- Reaction "095" (CaMKII_CaM → CaMKII_286_CaM)
- Reaction "r51" (PDE2 + IBMX → PDE2_IBMX)
- Reaction "029" (MEK_Ser → MEK_active)
- Reaction "089" (CaM + 2 Calcium → CaM_Ca2)
- Reaction "r53" (I1_Pi + PP1 → I1_Pi_PP1)
- Reaction "082" (R2C2 + cAMP → R2C2_cAMP)
- Reaction "040" (STEP → STEP_PKA)
- Reaction "r9" (PDE4 + Rolipram → PDE4_Rolipram)
- Reaction "052" (PDE4_ERK → PDE4_ERK_PKA)
- Reaction "079" (cAMP → AMP)
- Reaction "037" (ERK_Tyr → ERK_active)
- Reaction "016" (Ras_GTP + Raf → Ras_Raf_active)
- Reaction "093" (CaMKII_286 + CaM_Ca4 → CaMKII_286_CaM)
- Reaction "r54" (I1_Pi_PP1 → PP1 + I1)
- Reaction "080" (cAMP → AMP)
- Reaction "049" (PDE4_PKA → PDE4_ERK_PKA)
- Reaction "r16" (MEK + U0126 → MEK_inhibited)
- Reaction "r39" (IP3_145 → IP3_14)
- Reaction "047" (PDE4 → PDE4_ERK)
- Reaction "r5" (PDE1_CaM_Ca4 + IBMX → PDE1_IBMX)
- Reaction "044" (ERK_Tyr → ERK)
- Reaction "083" (cAMP + R2C2_cAMP → R2C2_cAMP2)
- Reaction "090" (CaM_Ca2 + Calcium → CaM_Ca3)
- Reaction "028" (MEK → MEK_Ser)
- Reaction "094" (CaMKII → CaMKII_286)
- Reaction "035" (MEK_Ser → MEK_active)
- Reaction "033" (MEK_active → MEK_Ser)
- Reaction "r14" (MEK_Ser + U0126 → MEK_inhibited)
- Reaction "r15" (MEK_active + U0126 → MEK_inhibited)
- Reaction "108" (GluR1_845 → GluR1)
- Reaction "r57" (GluR1_845 → GluR1_845_818)
- Reaction "r8" (Rolipram + PDE4_ERK → PDE4_Rolipram)
- Reaction "r23" (PDE4_ERK_PKA + IBMX → PDE4_IBMX)
- Reaction "061" (I1_Pi → I1)
- Reaction "014" (Ras_GTP → Ras_GDP)
- Reaction "062" (BRaf → BRaf_Pi)
- Reaction "099" (PDE1_CaM_Ca4 → PDE1)
- Reaction "086" (R2C2_cAMP4 → PKA_active + R2C_cAMP4)
- Reaction "048" (PDE4_ERK → PDE4)
- Reaction "043" (ERK_Tyr → ERK)
- Reaction "085" (R2C2_cAMP3 + cAMP → R2C2_cAMP4)
- Reaction "092" (CaM_Ca4 + CaMKII → CaMKII_CaM)
- Reaction "041" (STEP_PKA → STEP)
- Compartment "EC". (type: Volume)
- Species "BDNF"
- Species "Da"
- Species "Fsk"
- Compartment "ER". (type: Volume)
- Species "Calcium_ER"
- Compartment "PM". (type: Membrane)
- Species "Gby"
- Species "AC5_Ga"
- Species "D1LR_Gqby"
- Species "GluR1_Membrane"
- Species "Gqby"
- Species "PLC"
- Species "PLC_Ca"
- Species "PLC_Ca_Gq"
- Species "AC_basal"
- Species "G_by"
- Species "Gq_GDP"
- Species "Da_D5R"
- Species "Gaby"
- Species "Da_D5R_Gaby"
- Species "AC5"
- Species "BDNF_TrkB"
- Species "AC5_Fsk"
- Species "D1R_Gaby"
- Species "Gq_GTP"
- Species "TrkB"
- Species "D1LR"
- Species "PLC_Gq"
- Species "Ga_GDP"
- Species "D5R_Gaby"
- Species "BDNF_TrkB2"
- Species "Ga_GTP"
- Species "Da_D1R_Gaby"
- Species "D1R"
- Species "PIP2"
- Species "Da_D1LR_Gqby"
- Species "Int_TrkB2"
- Species "DAG"
- Species "Da_D1R"
- Species "D5R"
- Species "GluR1_Membrane_dephosphorylated1"
- Species "Da_D1LR"
- Reaction "005" (Int_TrkB2 → TrkB)
- Reaction "r20" (Da + D1LR_Gqby → Da_D1LR_Gqby)
- Reaction "r28" (Da_D1LR_Gqby → G_by + Da_D1LR + Gq_GTP)
- Reaction "r7" (AC5 + Fsk → AC5_Fsk)
- Reaction "064" (Da + D1R → Da_D1R)
- Reaction "103" (Four1N + GluR1_845_818 → GluR1_Membrane)
- Reaction "073" (Ga_GDP + Gby → Gaby)
- Reaction "r0" (Da_D5R_Gaby → Da_D5R + Gby + Ga_GTP)
- Reaction "r3" (ATP → cAMP)
- Reaction "071" (Da_D5R + Gaby → Da_D5R_Gaby)
- Reaction "002" (TrkB + BDNF_TrkB → BDNF_TrkB2)
- Reaction "r35" (PLC + Calcium → PLC_Ca)
- Reaction "001" (BDNF + TrkB → BDNF_TrkB)
- Reaction "r36" (PLC_Gq → Gq_GDP + PLC)
- Reaction "r26" (Da + D1LR → Da_D1LR)
- Reaction "104" (GluR1_Membrane_dephosphorylated1 → GluR1 + Four1N)
- Reaction "r27" (Da_D1LR + Gqby → Da_D1LR_Gqby)
- Reaction "075" (Ga_GTP + AC5 → AC5_Ga)
- Reaction "004" (BDNF_TrkB2_Pi → Int_TrkB2)
- Reaction "r37" (PLC_Gq + Calcium → PLC_Ca_Gq)
- Reaction "r32" (PIP2 → DAG + IP3_145)
- Reaction "r29" (Gq_GDP + G_by → Gqby)
- Reaction "067" (D1R_Gaby + Da → Da_D1R_Gaby)
- Reaction "r31" (PIP2 → IP3_145 + DAG)
- Reaction "r34" (PLC + Gq_GTP → PLC_Gq)
- Reaction "r1" (ATP → cAMP)
- Reaction "105" (GluR1_Membrane → GluR1_degraded)
- Reaction "065" (Gaby + D1R → D1R_Gaby)
- Reaction "r33" (PIP2 → DAG + IP3_145)
- Reaction "070" (Da + D5R_Gaby → Da_D5R_Gaby)
- Reaction "r30" (Gq_GTP → Gq_GDP)
- Reaction "069" (Gaby + D5R → D5R_Gaby)
- Reaction "r4" (ATP → cAMP)
- Reaction "074" (Ga_GTP → Ga_GDP)
- Reaction "072" (Da_D1R_Gaby → Gby + Ga_GTP + Da_D1R)
- Reaction "068" (D5R + Da → Da_D5R)
- Reaction "003" (BDNF_TrkB2 → BDNF_TrkB2_Pi)
- Reaction "r13" (Gqby + D1LR → D1LR_Gqby)
- Reaction "066" (Gaby + Da_D1R → Da_D1R_Gaby)
- Reaction "r17" (GluR1_Membrane → GluR1_Membrane_dephosphorylated1)
- Reaction "r25" (ATP → cAMP)
- Compartment "ER_Membrane". (type: Membrane)
- Species "IP3R"
- Species "IP3R_open"
- Species "SERCA"
- Species "SERCA_active"
- Reaction "r44" (Calcium → Calcium_ER)
- Reaction "r43" (Calcium_ER → Calcium)
- Reaction "r45" (Calcium_ER → Calcium)
- Reaction "r42" (SERCA + Calcium → SERCA_active)
- Reaction "r41" (IP3R + 3 IP3_145 → IP3R_open)