Name: “Nck Induces Actin Comet Tail Formation – Dimer Nck Binds NWASP With Dimer NWASP Activation of Arp2/3. Simplified Actin Dendritic Nucleation.1”
Saved: Sat, 11 Feb 2012 11:19:53 GMT
vcell identifier: biomodel-62585003
Owned by: “JDitlev”
- Compartment "cyt". (type: Volume)
- Species "Fi_cyt"
- Species "Fd_cyt"
- Species "BthyGd_cyt"
- Species "CapBarb_cyt"
- Species "BarbI_cyt"
- Species "BarbD_cyt"
- Species "BranchI_cyt"
- Species "Cof_cyt"
- Species "PointD_cyt"
- Species "CofFd_cyt"
- Species "ProfGd_cyt"
- Species "BranchD_cyt"
- Species "Prof_cyt"
- Species "BthyGt_cyt"
- Species "Bthy_cyt"
- Species "Arp23_cyt"
- Species "PointT_cyt"
- Species "PointI_cyt"
- Species "CofFd2_cyt"
- Species "Gt_cyt"
- Species "BarbT_cyt"
- Species "Cap_cyt"
- Species "Gd_cyt"
- Species "NWASP_WIP_cyt"
- Species "ProfGt_cyt"
- Reaction "Gt adds to PointI" (Gt_cyt + PointI_cyt → PointT_cyt + Fi_cyt)
- Reaction "Prof binds Gd to form ProfGd complex" (Gd_cyt + Prof_cyt → ProfGd_cyt)
- Reaction "F-actin Pi release " (Fi_cyt → Fd_cyt)
- Reaction "BranchD dissociates to PointI and Fd" (BranchD_cyt → PointI_cyt + Arp23_cyt + Fd_cyt)
- Reaction "Gt adds to PointT" (Gt_cyt → Fi_cyt)
- Reaction "Gt adds to BarbT" (Gt_cyt → Fi_cyt)
- Reaction "BarbD and PointT anneal" (BarbD_cyt + PointT_cyt → Fi_cyt + Fd_cyt)
- Reaction "ProfGd adds to BarbT giving BarbD" (BarbT_cyt + ProfGd_cyt → BarbD_cyt + Prof_cyt + Fi_cyt)
- Reaction "ProfGd adds to BarbD giving BarbD" (ProfGd_cyt → Fd_cyt + Prof_cyt)
- Reaction "ProfGt adds to BarbT" (ProfGt_cyt → Fi_cyt + Prof_cyt)
- Reaction "ProfGt adds to BarbD" (ProfGt_cyt + BarbD_cyt → BarbT_cyt + Fd_cyt + Prof_cyt)
- Reaction "Barbed end hydrolysis" (BarbT_cyt → BarbI_cyt)
- Reaction "ProfGd adds to BarbI giving BarbD" (ProfGd_cyt + BarbI_cyt → BarbD_cyt + Fi_cyt + Prof_cyt)
- Reaction "Cofilin binds to Fd" (Cof_cyt + Fd_cyt → CofFd_cyt)
- Reaction "Gd adds to PointD gives PointD" (Gd_cyt → Fd_cyt)
- Reaction "BranchD dissociates to PointD and Fd" (BranchD_cyt → Fd_cyt + Arp23_cyt + PointD_cyt)
- Reaction "Gd adds to PointT gives PointD" (PointT_cyt + Gd_cyt → Fi_cyt + PointD_cyt)
- Reaction "BarbI and PointI anneal" (PointI_cyt + BarbI_cyt → 2 Fi_cyt)
- Reaction "Gt adds to BarbD" (BarbD_cyt + Gt_cyt → BarbT_cyt + Fd_cyt)
- Reaction "BarbD and PointI anneal" (BarbD_cyt + PointI_cyt → Fi_cyt + Fd_cyt)
- Reaction "ProfGd adds to BarbT giving BarbI" (ProfGd_cyt + BarbT_cyt → BarbI_cyt + Prof_cyt + Fi_cyt)
- Reaction "Bthymosin binds Gt to form Bthymosin-Gt complex" (Gt_cyt + Bthy_cyt → BthyGt_cyt)
- Reaction "Cap BarbT" (BarbT_cyt + Cap_cyt → CapBarb_cyt)
- Reaction "Bthymosin binds Gd to form Bthymosin-Gd complex" (Gd_cyt + Bthy_cyt → BthyGd_cyt)
- Reaction "Gt adds to BarbI" (BarbI_cyt + Gt_cyt → BarbT_cyt + Fi_cyt)
- Reaction "Prof binds Gt to form ProfGt complex" (Prof_cyt + Gt_cyt → ProfGt_cyt)
- Reaction "Branch point phophate release" (BranchI_cyt → BranchD_cyt)
- Reaction "BarbI and PointT anneal" (PointT_cyt + BarbI_cyt → 2 Fi_cyt)
- Reaction "Barbed end phosphate release" (BarbI_cyt → BarbD_cyt)
- Reaction "BarbD and PointD anneal" (PointD_cyt + BarbD_cyt → 2 Fd_cyt)
- Reaction "Gt adds to PointD" (Gt_cyt + PointD_cyt → Fd_cyt + PointT_cyt)
- Reaction "BranchT dissociates to PointT and Ft" (BranchI_cyt → Fi_cyt + Arp23_cyt + PointT_cyt)
- Reaction "Gd adds to BarbT giving BarbD" (Gd_cyt + BarbT_cyt → Fi_cyt + BarbD_cyt)
- Reaction "Gd adds to PointT gives PointI" (Gd_cyt + PointT_cyt → PointI_cyt + Fi_cyt)
- Reaction "Second cofilin binds next to CofFd" (Cof_cyt + Fd_cyt + CofFd_cyt → CofFd2_cyt)
- Reaction "BranchD dissociates to PointT and Fd" (BranchD_cyt → PointT_cyt + Fd_cyt + Arp23_cyt)
- Reaction "Adjacent cofilins sever" (2 Fd_cyt → PointD_cyt + BarbD_cyt)
- Reaction "ProfGd adds to BarbD giving BarbI" (ProfGd_cyt + BarbD_cyt → Fd_cyt + Prof_cyt + BarbI_cyt)
- Reaction "Gd adds to BarbI giving BarbI" (Gd_cyt → Fi_cyt)
- Reaction "Gd adds to PointI gives PointI" (Gd_cyt → Fi_cyt)
- Reaction "Pointed end phosphate release" (PointI_cyt → PointD_cyt)
- Reaction "Gd adds to BarbD giving BarbD" (Gd_cyt → Fd_cyt)
- Reaction "Cofilin binds Ft, releases phosphate to give CofFd" (Cof_cyt + Fi_cyt → CofFd_cyt)
- Reaction "Gd adds to BarbI giving BarbD" (Gd_cyt + BarbI_cyt → BarbD_cyt + Fi_cyt)
- Reaction "ProfGd adds to BarbI giving BarbI" (ProfGd_cyt → Prof_cyt + Fi_cyt)
- Reaction "Cap BarbI" (Cap_cyt + BarbI_cyt → CapBarb_cyt)
- Reaction "BarbT and PointT anneal" (PointT_cyt + BarbT_cyt → 2 Fi_cyt)
- Reaction "BranchT dissociates to PointD and Ft" (BranchI_cyt → Arp23_cyt + PointD_cyt + Fi_cyt)
- Reaction "Gd adds to BarbT giving BarbI" (Gd_cyt + BarbT_cyt → BarbI_cyt + Fi_cyt)
- Reaction "Gd adds to PointD gives PointI" (PointD_cyt + Gd_cyt → PointI_cyt + Fd_cyt)
- Reaction "Cofilin mediated severing" (CofFd2_cyt → 2 Cof_cyt + PointD_cyt + BarbD_cyt)
- Reaction "Nucleotide exchange on G-actin" (Gd_cyt → Gt_cyt)
- Reaction "ProfGt adds to BarbI" (ProfGt_cyt + BarbI_cyt → BarbT_cyt + Prof_cyt + Fi_cyt)
- Reaction "Pointed end hydrolysis" (PointT_cyt → PointI_cyt)
- Reaction "BarbI and PointD anneal" (BarbI_cyt + PointD_cyt → Fi_cyt + Fd_cyt)
- Reaction "BranchT dissociates to PointI and Ft" (BranchI_cyt → PointI_cyt + Arp23_cyt + Fi_cyt)
- Reaction "BarbT and PointD anneal" (BarbT_cyt + PointD_cyt → Fi_cyt + Fd_cyt)
- Reaction "Nucleotide exchange on Prof-G-actin complex" (ProfGd_cyt → ProfGt_cyt)
- Reaction "BarbT and PointI anneal" (BarbT_cyt + PointI_cyt → 2 Fi_cyt)
- Reaction "Cap BarbD" (Cap_cyt + BarbD_cyt → CapBarb_cyt)
- Reaction "Gd adds to PointI gives PointD" (Gd_cyt + PointI_cyt → Fi_cyt + PointD_cyt)
- Reaction "Gd adds to BarbD giving BarbI" (Gd_cyt + BarbD_cyt → Fd_cyt + BarbI_cyt)
- Compartment "ec". (type: Volume)
- Compartment "mem". (type: Membrane)
- Species "ActiveNWASP_mem"
- Species "ActiveArp23_mem"
- Species "NckSH3_mem"
- Reaction "Nck Activates NWASP" (2 NckSH3_mem + NWASP_WIP_cyt → ActiveNWASP_mem)
- Reaction "ProfGt nucleates branch on Ft" (ActiveArp23_mem + 2 ProfGt_cyt + Fi_cyt → BarbT_cyt + BranchI_cyt + 2 Prof_cyt + 2 ActiveNWASP_mem)
- Reaction "Formation of Active Arp23 Complex" (Arp23_cyt + 2 ActiveNWASP_mem → ActiveArp23_mem)
- Reaction "Gt nucleates branch on Ft" (ActiveArp23_mem + Fi_cyt + 2 Gt_cyt → BarbT_cyt + BranchI_cyt + 2 ActiveNWASP_mem)