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biomodel-62585003

Name: “Nck Induces Actin Comet Tail Formation – Dimer Nck Binds NWASP With Dimer NWASP Activation of Arp2/3. Simplified Actin Dendritic Nucleation.1”
Saved: Sat, 11 Feb 2012  11:19:53 GMT
vcell identifier: biomodel-62585003
Owned by: “JDitlev”

download model (.vcml)

Compartments, Species, Reactions
  • Compartment "cyt".   (type: Volume)
    • Species "Fi_cyt"
    • Species "Fd_cyt"
    • Species "BthyGd_cyt"
    • Species "CapBarb_cyt"
    • Species "BarbI_cyt"
    • Species "BarbD_cyt"
    • Species "BranchI_cyt"
    • Species "Cof_cyt"
    • Species "PointD_cyt"
    • Species "CofFd_cyt"
    • Species "ProfGd_cyt"
    • Species "BranchD_cyt"
    • Species "Prof_cyt"
    • Species "BthyGt_cyt"
    • Species "Bthy_cyt"
    • Species "Arp23_cyt"
    • Species "PointT_cyt"
    • Species "PointI_cyt"
    • Species "CofFd2_cyt"
    • Species "Gt_cyt"
    • Species "BarbT_cyt"
    • Species "Cap_cyt"
    • Species "Gd_cyt"
    • Species "NWASP_WIP_cyt"
    • Species "ProfGt_cyt"
    • Reaction "Gt adds to PointI"   (Gt_cyt + PointI_cyt → PointT_cyt + Fi_cyt)
    • Reaction "Prof binds Gd to form ProfGd complex"   (Gd_cyt + Prof_cyt → ProfGd_cyt)
    • Reaction "F-actin Pi release "   (Fi_cyt → Fd_cyt)
    • Reaction "BranchD dissociates to PointI and Fd"   (BranchD_cyt → PointI_cyt + Arp23_cyt + Fd_cyt)
    • Reaction "Gt adds to PointT"   (Gt_cyt → Fi_cyt)
    • Reaction "Gt adds to BarbT"   (Gt_cyt → Fi_cyt)
    • Reaction "BarbD and PointT anneal"   (BarbD_cyt + PointT_cyt → Fi_cyt + Fd_cyt)
    • Reaction "ProfGd adds to BarbT giving BarbD"   (BarbT_cyt + ProfGd_cyt → BarbD_cyt + Prof_cyt + Fi_cyt)
    • Reaction "ProfGd adds to BarbD giving BarbD"   (ProfGd_cyt → Fd_cyt + Prof_cyt)
    • Reaction "ProfGt adds to BarbT"   (ProfGt_cyt → Fi_cyt + Prof_cyt)
    • Reaction "ProfGt adds to BarbD"   (ProfGt_cyt + BarbD_cyt → BarbT_cyt + Fd_cyt + Prof_cyt)
    • Reaction "Barbed end hydrolysis"   (BarbT_cyt → BarbI_cyt)
    • Reaction "ProfGd adds to BarbI giving BarbD"   (ProfGd_cyt + BarbI_cyt → BarbD_cyt + Fi_cyt + Prof_cyt)
    • Reaction "Cofilin binds to Fd"   (Cof_cyt + Fd_cyt → CofFd_cyt)
    • Reaction "Gd adds to PointD gives PointD"   (Gd_cyt → Fd_cyt)
    • Reaction "BranchD dissociates to PointD and Fd"   (BranchD_cyt → Fd_cyt + Arp23_cyt + PointD_cyt)
    • Reaction "Gd adds to PointT gives PointD"   (PointT_cyt + Gd_cyt → Fi_cyt + PointD_cyt)
    • Reaction "BarbI and PointI anneal"   (PointI_cyt + BarbI_cyt → 2 Fi_cyt)
    • Reaction "Gt adds to BarbD"   (BarbD_cyt + Gt_cyt → BarbT_cyt + Fd_cyt)
    • Reaction "BarbD and PointI anneal"   (BarbD_cyt + PointI_cyt → Fi_cyt + Fd_cyt)
    • Reaction "ProfGd adds to BarbT giving BarbI"   (ProfGd_cyt + BarbT_cyt → BarbI_cyt + Prof_cyt + Fi_cyt)
    • Reaction "Bthymosin binds Gt to form Bthymosin-Gt complex"   (Gt_cyt + Bthy_cyt → BthyGt_cyt)
    • Reaction "Cap BarbT"   (BarbT_cyt + Cap_cyt → CapBarb_cyt)
    • Reaction "Bthymosin binds Gd to form Bthymosin-Gd complex"   (Gd_cyt + Bthy_cyt → BthyGd_cyt)
    • Reaction "Gt adds to BarbI"   (BarbI_cyt + Gt_cyt → BarbT_cyt + Fi_cyt)
    • Reaction "Prof binds Gt to form ProfGt complex"   (Prof_cyt + Gt_cyt → ProfGt_cyt)
    • Reaction "Branch point phophate release"   (BranchI_cyt → BranchD_cyt)
    • Reaction "BarbI and PointT anneal"   (PointT_cyt + BarbI_cyt → 2 Fi_cyt)
    • Reaction "Barbed end phosphate release"   (BarbI_cyt → BarbD_cyt)
    • Reaction "BarbD and PointD anneal"   (PointD_cyt + BarbD_cyt → 2 Fd_cyt)
    • Reaction "Gt adds to PointD"   (Gt_cyt + PointD_cyt → Fd_cyt + PointT_cyt)
    • Reaction "BranchT dissociates to PointT and Ft"   (BranchI_cyt → Fi_cyt + Arp23_cyt + PointT_cyt)
    • Reaction "Gd adds to BarbT giving BarbD"   (Gd_cyt + BarbT_cyt → Fi_cyt + BarbD_cyt)
    • Reaction "Gd adds to PointT gives PointI"   (Gd_cyt + PointT_cyt → PointI_cyt + Fi_cyt)
    • Reaction "Second cofilin binds next to CofFd"   (Cof_cyt + Fd_cyt + CofFd_cyt → CofFd2_cyt)
    • Reaction "BranchD dissociates to PointT and Fd"   (BranchD_cyt → PointT_cyt + Fd_cyt + Arp23_cyt)
    • Reaction "Adjacent cofilins sever"   (2 Fd_cyt → PointD_cyt + BarbD_cyt)
    • Reaction "ProfGd adds to BarbD giving BarbI"   (ProfGd_cyt + BarbD_cyt → Fd_cyt + Prof_cyt + BarbI_cyt)
    • Reaction "Gd adds to BarbI giving BarbI"   (Gd_cyt → Fi_cyt)
    • Reaction "Gd adds to PointI gives PointI"   (Gd_cyt → Fi_cyt)
    • Reaction "Pointed end phosphate release"   (PointI_cyt → PointD_cyt)
    • Reaction "Gd adds to BarbD giving BarbD"   (Gd_cyt → Fd_cyt)
    • Reaction "Cofilin binds Ft, releases phosphate to give CofFd"   (Cof_cyt + Fi_cyt → CofFd_cyt)
    • Reaction "Gd adds to BarbI giving BarbD"   (Gd_cyt + BarbI_cyt → BarbD_cyt + Fi_cyt)
    • Reaction "ProfGd adds to BarbI giving BarbI"   (ProfGd_cyt → Prof_cyt + Fi_cyt)
    • Reaction "Cap BarbI"   (Cap_cyt + BarbI_cyt → CapBarb_cyt)
    • Reaction "BarbT and PointT anneal"   (PointT_cyt + BarbT_cyt → 2 Fi_cyt)
    • Reaction "BranchT dissociates to PointD and Ft"   (BranchI_cyt → Arp23_cyt + PointD_cyt + Fi_cyt)
    • Reaction "Gd adds to BarbT giving BarbI"   (Gd_cyt + BarbT_cyt → BarbI_cyt + Fi_cyt)
    • Reaction "Gd adds to PointD gives PointI"   (PointD_cyt + Gd_cyt → PointI_cyt + Fd_cyt)
    • Reaction "Cofilin mediated severing"   (CofFd2_cyt → 2 Cof_cyt + PointD_cyt + BarbD_cyt)
    • Reaction "Nucleotide exchange on G-actin"   (Gd_cyt → Gt_cyt)
    • Reaction "ProfGt adds to BarbI"   (ProfGt_cyt + BarbI_cyt → BarbT_cyt + Prof_cyt + Fi_cyt)
    • Reaction "Pointed end hydrolysis"   (PointT_cyt → PointI_cyt)
    • Reaction "BarbI and PointD anneal"   (BarbI_cyt + PointD_cyt → Fi_cyt + Fd_cyt)
    • Reaction "BranchT dissociates to PointI and Ft"   (BranchI_cyt → PointI_cyt + Arp23_cyt + Fi_cyt)
    • Reaction "BarbT and PointD anneal"   (BarbT_cyt + PointD_cyt → Fi_cyt + Fd_cyt)
    • Reaction "Nucleotide exchange on Prof-G-actin complex"   (ProfGd_cyt → ProfGt_cyt)
    • Reaction "BarbT and PointI anneal"   (BarbT_cyt + PointI_cyt → 2 Fi_cyt)
    • Reaction "Cap BarbD"   (Cap_cyt + BarbD_cyt → CapBarb_cyt)
    • Reaction "Gd adds to PointI gives PointD"   (Gd_cyt + PointI_cyt → Fi_cyt + PointD_cyt)
    • Reaction "Gd adds to BarbD giving BarbI"   (Gd_cyt + BarbD_cyt → Fd_cyt + BarbI_cyt)
  • Compartment "ec".   (type: Volume)
  • Compartment "mem".   (type: Membrane)
    • Species "ActiveNWASP_mem"
    • Species "ActiveArp23_mem"
    • Species "NckSH3_mem"
    • Reaction "Nck Activates NWASP"   (2 NckSH3_mem + NWASP_WIP_cyt → ActiveNWASP_mem)
    • Reaction "ProfGt nucleates branch on Ft"   (ActiveArp23_mem + 2 ProfGt_cyt + Fi_cyt → BarbT_cyt + BranchI_cyt + 2 Prof_cyt + 2 ActiveNWASP_mem)
    • Reaction "Formation of Active Arp23 Complex"   (Arp23_cyt + 2 ActiveNWASP_mem → ActiveArp23_mem)
    • Reaction "Gt nucleates branch on Ft"   (ActiveArp23_mem + Fi_cyt + 2 Gt_cyt → BarbT_cyt + BranchI_cyt + 2 ActiveNWASP_mem)
2020-09-14T16:38:29+00:00 February 16th, 2018|biomodel|
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