Name: “Podocyte Nested FFM model”
Saved: Tue, 14 May 2013 10:18:47 GMT
vcell identifier: biomodel-81992349
Owned by: “sihar”
- Compartment "cell". (type: Volume)
- Species "R2C2_cell"
- Species "ATP_cell"
- Species "MKP1_cell"
- Species "AMP_cell"
- Species "BRaf_cell"
- Species "MAPK_act_cell"
- Species "cAMP4_R2C2_cell"
- Species "cAMP4_R2C_cell"
- Species "cAMP4_R2_cell"
- Species "MKP1p_cell"
- Species "MKP2_cell"
- Species "PDE_star_cell"
- Species "PP2A_cell"
- Species "cAMP_R2C2_cell"
- Species "Epac_cAMP_cell"
- Species "cAMP2_R2C2_cell"
- Species "PKA_cell"
- Species "MAPKK_Ser_cell"
- Species "PKI_cell"
- Species "inhibitedPKA_cell"
- Species "MAPK_active_cell"
- Species "Rap1GAP_cell"
- Species "MAPKK_cell"
- Species "cAMP3_R2C2_cell"
- Species "cAMP_cell"
- Species "PP1_cell"
- Species "PTPSL_star_cell"
- Species "Epac_cell"
- Species "MKP1_RNA_cell"
- Species "MAPKK_active_cell"
- Species "GRK_cell"
- Species "PDE_cell"
- Species "PTPSL_cell"
- Species "MAPK_Thr_cell"
- Species "PDE_PP_cell"
- Species "PDE_highKm_cell"
- Species "BRaf_star_cell"
- Species "MAPK_cell"
- Reaction "PP_deact_BRaf" (BRaf_star_cell → BRaf_cell)
- Reaction "PKA_act_BRaf" (BRaf_cell → BRaf_star_cell)
- Reaction "Release of C1" (cAMP4_R2C2_cell → cAMP4_R2C_cell + PKA_cell)
- Reaction "MKP1 phospho by MAPKactive" (MKP1_cell → MKP1p_cell)
- Reaction "07: PDE" (cAMP_cell → AMP_cell)
- Reaction "PTPSL_dephos" (PTPSL_star_cell → PTPSL_cell)
- Reaction "MAPKK_act_MAPK_thr" (MAPK_Thr_cell → MAPK_active_cell)
- Reaction "PKA_act_PDE" (PDE_cell → PDE_star_cell)
- Reaction "PP2A_inact_MAPKK_active" (MAPKK_active_cell → MAPKK_Ser_cell)
- Reaction "PKA release by PKI" (inhibitedPKA_cell → PKI_cell + PKA_cell)
- Reaction "cAMP_binds_A2" (cAMP3_R2C2_cell + cAMP_cell → cAMP4_R2C2_cell)
- Reaction "BRaf_act_MAPKK" (MAPKK_cell → MAPKK_Ser_cell)
- Reaction "Epac-cAMP binding" (cAMP_cell + Epac_cell → Epac_cAMP_cell)
- Reaction "MKPp_decat_MAPKtyr" (MAPK_Thr_cell → MAPK_cell)
- Reaction "PKA_deact_PTPSL" (PTPSL_cell → PTPSL_star_cell)
- Reaction "PDE_highKm deact cAMP" (cAMP_cell → AMP_cell)
- Reaction "MAPK dephosph by PTP" (MAPK_active_cell → MAPK_Thr_cell)
- Reaction "cAMP_bind_cAMP2R2C2" (cAMP_cell + cAMP2_R2C2_cell → cAMP3_R2C2_cell)
- Reaction "MKP1_deact_MAPKactive" (MAPK_active_cell → MAPK_Thr_cell)
- Reaction "cAMP bind R2C2" (R2C2_cell + cAMP_cell → cAMP_R2C2_cell)
- Reaction "PDEstar_deact_cAMP" (cAMP_cell → AMP_cell)
- Reaction "Release of C2" (cAMP4_R2C_cell → cAMP4_R2_cell + PKA_cell)
- Reaction "MKP1 turnover" (MKP1_cell → ∅)
- Reaction "cAMP_binds_cAMPR2C2" (cAMP_R2C2_cell + cAMP_cell → cAMP2_R2C2_cell)
- Reaction "PP2A_inact_MAPKKSer" (MAPKK_Ser_cell → MAPKK_cell)
- Reaction "MAPKK_act_MAPK" (MAPK_cell → MAPK_Thr_cell)
- Reaction "MKP_translation" (MKP1_RNA_cell → MKP1_cell)
- Reaction "reaction1" (MAPKK_Ser_cell → MAPKK_active_cell)
- Reaction "PP2A_dephos_PDEstar" (PDE_star_cell → PDE_cell)
- Reaction "reaction0" (MAPK_Thr_cell → MAPK_cell)
- Reaction "reaction3" (MAPK_active_cell → MAPK_Thr_cell)
- Reaction "MKP_decat_MAPKtyr" (MAPK_Thr_cell → MAPK_cell)
- Reaction "MKP1p turnover" (MKP1p_cell → ∅)
- Reaction "MKP1 dephosph" (MKP1p_cell → MKP1_cell)
- Reaction "MKP1p_deact_MAPKactive" (MAPK_active_cell → MAPK_Thr_cell)
- Compartment "ec". (type: Volume)
- Species "isoprenaline_ec"
- Compartment "golgi". (type: Volume)
- Compartment "nucleus". (type: Volume)
- Species "MSK_nucleus"
- Species "MSK_active_nucleus"
- Species "MAPK_nucleus"
- Species "MKP1_nucleus"
- Species "MKP2_nucleus"
- Species "MAPK_thr_nucleus"
- Species "MKP1p_nucleus"
- Species "MKP1gene_nucleus"
- Species "MAPK_active_nucleus"
- Species "MKP1_RNA_nucleus"
- Species "inhibitedPKA_nucleus"
- Species "PP1A_nucleus"
- Species "CREB_Ser_nucleus"
- Species "PKI_nucleus"
- Species "pp2a_nucleus"
- Species "CREB_nucleus"
- Species "PKA_nucleus"
- Reaction "MKP1p turnover nucleus" (MKP1p_nucleus → ∅)
- Reaction "MKP1p deact MAPKact" (MAPK_active_nucleus → MAPK_thr_nucleus)
- Reaction "MKP1 turnover in nucleus" (MKP1_nucleus → ∅)
- Reaction "MKP1p deact MAPKtyr" (MAPK_thr_nucleus → MAPK_nucleus)
- Reaction "MSK_act_CREB" (CREB_nucleus → CREB_Ser_nucleus)
- Reaction "MSK_dephos" (MSK_active_nucleus → MSK_nucleus)
- Reaction "PKA_act_CREB" (CREB_nucleus → CREB_Ser_nucleus)
- Reaction "PP1A_dephos_CREB" (CREB_Ser_nucleus → CREB_nucleus)
- Reaction "MKP1 deact MAPKact" (MAPK_active_nucleus → MAPK_thr_nucleus)
- Reaction "MKP1 deact MAPKtyr " (MAPK_thr_nucleus → MAPK_nucleus)
- Reaction "reaction2" (MSK_nucleus → MSK_active_nucleus)
- Reaction "MKP2 deact MAPKact" (MAPK_active_nucleus → MAPK_thr_nucleus)
- Reaction "MKP2 deact MAPK tyr" (MAPK_thr_nucleus → MAPK_nucleus)
- Reaction "MKP1 phosph by MAPKactive_nucleus" (MKP1_nucleus → MKP1p_nucleus)
- Reaction "MKP1 dephosph in nucleus" (MKP1p_nucleus → MKP1_nucleus)
- Reaction "PKA inhibition by PKI" (PKI_nucleus + PKA_nucleus → inhibitedPKA_nucleus)
- Reaction "Pp2A_deact_CREB" (CREB_Ser_nucleus → CREB_nucleus)
- Reaction "MAPK_act_MKPtranscription" (MKP1gene_nucleus → MKP1_RNA_nucleus)
- Reaction "MKP1 basal transcription" (MKP1gene_nucleus → MKP1_RNA_nucleus)
- Compartment "GM". (type: Membrane)
- Species "Rap1_RGII_GM"
- Species "Rap1_GDP_GM"
- Species "Rap1_Epac_GM"
- Species "Rap1_BRaf_GM"
- Species "Rap1_GTP_GM"
- Reaction "08: Epac exchange" (Rap1_Epac_GM → Epac_cAMP_cell + Rap1_GTP_GM)
- Reaction "Rap1raf_act_MAPKK" (MAPKK_cell → MAPKK_Ser_cell)
- Reaction "8a: Rap1-Epac binding" (Rap1_GDP_GM + Epac_cAMP_cell → Rap1_Epac_GM)
- Reaction "constit exch+hydrolysis" (Rap1_GDP_GM → Rap1_GTP_GM)
- Reaction "10a: Rap1-RGII binding" (Rap1GAP_cell + Rap1_GTP_GM → Rap1_RGII_GM)
- Reaction "10: Rap1 GTPase" (Rap1_RGII_GM → Rap1_GDP_GM + Rap1GAP_cell)
- Reaction "RapRaf_act_MAPKKSer" (MAPKK_Ser_cell → MAPKK_active_cell)
- Reaction "Rap1_binds_BRaf" (BRaf_cell + Rap1_GTP_GM → Rap1_BRaf_GM)
- Compartment "PM". (type: Membrane)
- Species "G_bg_PM"
- Species "Gsa_GDP_PM"
- Species "beta_isop_PM"
- Species "beta_PM"
- Species "beta_P_PM"
- Species "Gs_trimer_PM"
- Species "GRK_Gbg_PM"
- Species "Gs_a_PM"
- Species "AC_PM"
- Species "AC_Gsa_PM"
- Species "GRK_PM"
- Species "betaAR_Gs_PM"
- Reaction "GRK to cytosol" (GRK_PM → GRK_cell)
- Reaction "01b: isoprenaline binding" (isoprenaline_ec + beta_PM → beta_isop_PM)
- Reaction "Receptor recycling" (beta_P_PM → beta_PM)
- Reaction "GRK-Gbg binding" (G_bg_PM + GRK_cell → GRK_Gbg_PM)
- Reaction "14b: Gs trimerization" (Gsa_GDP_PM + G_bg_PM → Gs_trimer_PM)
- Reaction "04: Gs-AC binding" (Gs_a_PM + AC_PM → AC_Gsa_PM)
- Reaction "05b: cAMP production" (ATP_cell → cAMP_cell)
- Reaction "2: ARbeta-Gs binding" (beta_isop_PM + Gs_trimer_PM → betaAR_Gs_PM)
- Reaction "03: GRK activity" (beta_isop_PM → beta_P_PM)
- Reaction "Gs GTPase" (Gs_a_PM → Gsa_GDP_PM)
- Reaction "GRK PM recruitment" (GRK_Gbg_PM → GRK_PM + G_bg_PM)
- Reaction "02b: Gs activation" (betaAR_Gs_PM → beta_isop_PM + Gs_a_PM + G_bg_PM)
- Compartment "nuclear membrane". (type: Membrane)
- Reaction "PKI translocation" (PKI_cell → PKI_nucleus)
- Reaction "MKP1p translocation" (MKP1p_cell → MKP1p_nucleus)
- Reaction "MAPK translocation" (MAPK_cell → MAPK_nucleus)
- Reaction "MKP1 translocation" (MKP1_cell → MKP1_nucleus)
- Reaction "MAPKactive_translocation" (MAPK_active_cell → MAPK_active_nucleus)
- Reaction "PKA_translocation" (PKA_cell → PKA_nucleus)
- Reaction "inhibited PKA export" (inhibitedPKA_cell → inhibitedPKA_nucleus)
- Reaction "MKPRNA_export" (MKP1_RNA_cell → MKP1_RNA_nucleus)