2022-06-18. VCell collaborator Aurélie Carlier from Maastricht University published a manuscript on computational investigation of the dynamic control of cAMP signaling by PDE4 isoform types. The authors demonstrated that cAMP signaling is distinctly regulated by different PDE4 isoform types andthat this isoform-specificity should be considered in both computational and experimental follow-up studies to better define PDE4 enzymes as therapeutic targets in diseases in which cAMP signaling is aberrant.
Paes, D., Hermans, S., van den Hove, D., Vanmierlo, T., Prickaerts, J., Carlier, A. (2022). Biophys J., 121(14):2693-2711. doi: 10.1016/j.bpj.2022.06.019. Epub 2022 Jun 18.
https://pubmed.ncbi.nlm.nih.gov/35717559/
VCell biomodels are available at https://vcell.org/paes-2022