VCell 3-day course June 20-22, 2016
12 investigators traveled to CCAM to work with the VCell team, developing a model relevant to their specific research project.
New VCell model of blood coagulation factors
2016 -06-09 Hysteresis-like binding of coagulation factors x/xa to procoagulant activated platelets and phospholipids results from multistep association and membrane-dependent multimerization (Podoplelova et al. 2016. Biochim Biophys Acta. 1858:1216-1227. PMID 26874201). Find the public BioModel here.
New VCell Model from the Hille lab
VCell models were used to quantitatively analyze FRET measurements were used to demonstrate that voltage-sensing phosphatases (VSPs) have catalytic activity for PIP3 (Keum et al. 2016. Phosphoinositide 5- and 3-phosphatase activities of a voltage-sensing phosphatase in living cells show identical voltage dependence. Proc Natl Acad Sci U S A. 10.1073/pnas.1606472113, PMID 27222577). Find the public VCell model here.
New VCell model of G-protein coupled receptors
2016-05-03 A new model of pancreatic beta cell G-protein coupled receptors and second messenger interactions was recently published in PLoS One by Fridlyand and Philipson. Go to our Published Models listing to link to the publication and view details of the model.
New published VCell Model of protease-activated receptor 2 signaling.
2016-03-01. A new publication describes a VCell model that evaluates the contributions of protein kinases and beta-arrestin to termination of protease-activated receptor 2 signaling. Visit the Published Models page for details and links to the publication.
New method for particle-based simulations with excluded volume.
2016-02-02 SpringSaLad (Springs, Sites, and Langevin Dynamics) is a new software that uses a course-grained approach to model biomolecules as a group of linked spherical sites with excluded volumes. The software user material is available here. Read about the method and software in Springsalad: A spatial, particle-based biochemical simulation platform with excluded volume. Michalski, P.J., and L.M. Loew. 2016 Biophys J. 110:523-529. PMID 26840718.
New VCell Model of phosphoinositide signaling
2016-06-08 A new VCell Model from the Hille lab describes the dynamics of phosphoinositide signaling in sympathetic neurons. Details of the model and links to the publication can be found on our Published Models listing.
New VCell model of PAR2 desensitization
2016-03-15. A new VCell model of the mechanisms and kinetics of desensitization of the protease-activated receptor-2 (PAR2), a Gq-PCR, was published by Jung et al. in the Journal of General Physiology. Visit the Published Models listing to view the model details and link to the publication.