2021-3-18. A new paper by Kerbai Eroume in the Carlier lab published in PLOS One explores how cell shape affects the signaling mechanisms that determine cell polarization. Find links to the model and citation on our published models page.
2020-11-30. Announcing the release of VCell 7.3! VCell 7.3 adds capabilities for multiple trajectories for non-spatial stochastic simulationss, interchange with the Open Modeling EXchange format (.omex), and automatic assignment of catalysts in the reaction diagram as well as numerous additional improvements and bug fixes.
2020-11-17. A VCell model was used to explore Ca2+-cAMP-PKA signalling circuits in a new publication from the Rangamani and Zhang laboratories. Find links to the model and citation on our published models page.
2020-11-16. A new publication from the Lambert lab investigates the mechanisms that set the dynamic range of agonist-induced signaling using fluorescence imaging coupled with VCell modeling. Visit our published models page for links to the paper and to access the VCell model.
2020-9-3. A new VCell model created incollaboration between the McCulloch and Zhang labs helped to demonstrate that a second phase of RhoA activation is required to maintain RhoA-mediated transcription after receptor signalling ends. Find links to the model and paper by Zhang et al. on our published models page.
2020-10-20. A new publication from the Rangamani and Iyengar labs using VCell modeling to explore how cell shape affects calcium dynamics in vascular smooth muscle cells. Visit our published models page for links to the paper.
2020-08-05. The 2020 Computational Cell Biology Workshop was held as an online event Aug 3-5. Find videos of the key presentations here. Over 70 individuals participated overall; 16 individuals created models with VCell, COPASI and SpringSaLaD with help from CCAM team members in breakout rooms. A screen shot of one the opening day presentations serves in place of our traditional group photo this year.
2020-07-10. A new publication analyzes fluorescence photobleaching experiments using VCell numerical simulations to explore mechanisms of for differentiating somatodendritic and axonal compartments. Visit our published models page for links to the paper.
2020-04-07. A new spatial model of the PLC/PKC pahtway created in VCell was used to explore chemotactic sensing in fibroblasts in a new publication by Nosbisch et al from the Haugh lab. Visit our published models page for links to the paper and the VCell model.
2020-03-09. A new VCell model is used to explore how MYB proteins form an activator-inhibitor system that defines the spot pattern in mokeyflower petals. Visit our published models page for links to the paper and the VCell model.
